Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

Autor: Daria Zibrova, Asta Valanciute, Malcolm G. Dunlop, Vanessa P. Houde, Kevin A. Green, Dario R. Alessi, Farhat V N Din, Kei Sakamoto

Publikováno v: Din, F V N, Valanciute, A, Houde, V P, Zibrova, D, Green, K A, Sakamoto, K, Alessi, D R & Dunlop, M G 2012, ' Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells ', Gastroenterology, vol. 142, no. 7, pp. 1504-1515e3 . https://doi.org/10.1053/j.gastro.2012.02.050

BACKGROUND & AIMS: Aspirin reduces the incidence of and mortality from colorectal cancer (CRC) by unknown mechanisms. Cancer cells have defects in signaling via the mechanistic target of rapamycin (mTOR), which regulates proliferation. We investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df747e7cdae12149fe324e87254202c
https://www.pure.ed.ac.uk/ws/files/8384773/Aspirin_Inhibits_mTOR_Signaling_Activates_AMP_Activated_Protein_Kinase_and_Induces_Autophagy_in_Colorectal_Cancer_Cells.pdf