Evaluation of whole-cell and acellular pertussis vaccines in the context of long-term herd immunity

Autor: Ewa Szwejser-Zawislak, Mieszko M. Wilk, Piotr Piszczek, Justyna Krawczyk, Daria Wilczyńska, Daniela Hozbor

After the pertussis vaccine had been introduced in the 1940s and was shown to be very successful in reducing the morbidity and mortality associated with the disease, the possibility of improving both vaccine composition and vaccination schedules has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9727cacd62fcc139226d22f16f0fa6
https://ruj.uj.edu.pl/xmlui/handle/item/306629

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment

Autor: Annamaria Lubelska, Anna Wesołowska, Daria Wilczyńska, Magdalena Jastrzębska-Więsek, Anna Partyka, Katarzyna Kamińska, Małgorzata Anna Marć, Małgorzata Więcek, Gniewomir Latacz, Katarzyna Kieć-Kononowicz, Magdalena Kotańska, Jadwiga Handzlik, Grzegorz Satała

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3420 (2019)
Volume 20
Issue 14

Among serotonin receptors, the 5-HT6 subtype is the most controversial and the least known in the field of molecular mechanisms. The 5-HT6R ligands can be pivotal for innovative treatment of cognitive impairment, but none has reached pharmacological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b578c86d7f6a782fb0f5831f720836ed
http://europepmc.org/articles/PMC6678253

Novel aryloxyethyl derivatives of 1-(1-benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) phosphorylation-preferring serotonin 5 HT1A receptor biased agonists with robust antidepressant-like activity

Autor: Krzysztof Pociecha, Maciej Pawłowski, Daria Wilczyńska, Anna Wesołowska, Elżbieta Wyska, Karolina Pytka, Monika Głuch-Lutwin, Anna Partyka, Agata Siwek, Joanna Sniecikowska, Marcin Kołaczkowski, Adrian Newman-Tancredi, Adam Bucki, Agnieszka Cios, Mark A. Varney, Anna Więckowska, Magdalena Jastrzębska-Więsek

Novel 1-(1-benzoylpiperidin-4-yl)methanamine derivatives were designed as “biased agonists” of serotonin 5-HT1A receptors. The compounds were tested in signal transduction assays (ERK1/2 phosphorylation, cAMP inhibition, Ca2+ mobilization, and β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f9ff7c9dab9ea567c08af854d9ab0a
https://ruj.uj.edu.pl/xmlui/handle/item/145481

Selective 5-HT1A receptor agonists biased to pERK1/2 or β-arrestin activation show differential in vivo behavioral profiles

Autor: Magdalena Jastrzębska-Więsek, Daria Wilczyńska

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4f22b01793717633098888b43d58716
https://doi.org/10.26226/morressier.5b681763b56e9b005965c025

Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro.

Autor: Lubelska, Annamaria¹ (AUTHOR) annamaria.lubelska@doctoral.uj.edu.pl, Latacz, Gniewomir¹ (AUTHOR) glatacz@cm-uj.krakow.pl, Jastrzębska-Więsek, Magdalena² (AUTHOR) mj.wiesek@gmail.com, Kotańska, Magdalena³ (AUTHOR) magda.dudek@uj.edu.pl, Kurczab, Rafał⁴ (AUTHOR) kurczab@if-pan.krakow.pl, Partyka, Anna² (AUTHOR) annairena.partyka@uj.edu.pl, Marć, Małgorzata Anna¹ (AUTHOR) marcmalgorzata@gmail.com, Wilczyńska, Daria² (AUTHOR) daria.wilczynska@doctoral.uj.edu.pl, Doroz-Płonka, Agata¹ (AUTHOR) a.doroz-plonka@uj.edu.pl, Łażewska, Dorota¹ (AUTHOR) dlazewska@cm-uj.krakow.pl, Wesołowska, Anna² (AUTHOR) awesolowska@cm-uj.krakow.pl, Kieć-Kononowicz, Katarzyna¹ (AUTHOR) mfkonono@cyf-kr.edu.pl, Handzlik, Jadwiga¹ (AUTHOR) j.handzlik@uj.edu.pl, Sánchez-Murcia, Pedro A. (AUTHOR), Gigante, Alba (AUTHOR), Pérez, Víctor Sebastián (AUTHOR)

Publikováno v: Molecules. Dec2019, Vol. 24 Issue 24, p4472. 1p. 4 Diagrams, 3 Charts, 12 Graphs.