Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Daria Wells"'
Autor:
Johannes C. Botha, Dimiter Demirov, Carli Gordijn, Mary Grace Katusiime, Michael J. Bale, Xiaolin Wu, Daria Wells, Stephen H. Hughes, Mark F. Cotton, John W. Mellors, Mary F. Kearney, Gert U. van Zyl
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Combination antiretroviral therapy (cART) suppresses viral replication but does not cure HIV infection because a reservoir of infectious (intact) HIV proviruses persists in long-lived CD4+T cells. However, a large majority (>95%) of HIV-infe
Externí odkaz:
https://doaj.org/article/d5d9f7ebe1244d2c9af51df313d4cec7
Autor:
Shuang Guo, Brian T Luke, Amy R Henry, Samuel Darko, Leah D Brandt, Ling Su, David Sun, Daria Wells, Kevin W Joseph, Dimiter Demirov, Elias K Halvas, Daniel C Douek, Xiaolin Wu, John W Mellors, Stephen H Hughes
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010726 (2022)
Although combination antiretroviral therapy (ART) blocks HIV replication, it is not curative because infected CD4+ T cells that carry intact, infectious proviruses persist. Understanding the behavior of clones of infected T cells is important for und
Externí odkaz:
https://doaj.org/article/e4d901c328ff4314aeae578f4ca25641
Autor:
John M Coffin, Michael J Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M Zerbato, Michele D Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F Kearney, John W Mellors, Stephen H Hughes
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009141 (2021)
HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART. To better understand what controls HIV persistence and the distribution of
Externí odkaz:
https://doaj.org/article/3e177632677e4f3b9ab7e952f1029063
Autor:
Michael J. Bale, Mary Grace Katusiime, Daria Wells, Xiaolin Wu, Jonathan Spindler, Elias K. Halvas, Joshua C. Cyktor, Ann Wiegand, Wei Shao, Mark F. Cotton, Stephen H. Hughes, John W. Mellors, John M. Coffin, Gert U. Van Zyl, Mary F. Kearney
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
HIV-1 integrates its genome into the DNA of host cells. Consequently, HIV-1 genomes are copied with the host cell DNA during cellular division.
Externí odkaz:
https://doaj.org/article/24168db87d274281ba8cf37cddd5815b
Autor:
Elizabeth M. Anderson, Francesco R. Simonetti, Robert J. Gorelick, Shawn Hill, Monica A. Gouzoulis, Jennifer Bell, Catherine Rehm, Liliana Pérez, Eli Boritz, Xiaolin Wu, Daria Wells, Stephen H. Hughes, Venigalla Rao, John M. Coffin, Mary F. Kearney, Frank Maldarelli
Publikováno v:
Viruses, Vol 12, Iss 2, p 136 (2020)
Combination antiretroviral therapy (cART) controls but does not eradicate HIV infection; HIV persistence is the principal obstacle to curing infections. The proportion of defective proviruses increases during cART, but the dynamics of this process ar
Externí odkaz:
https://doaj.org/article/98e69d565b514117a7bf0360817fab15
Autor:
David Jetton, Rebecca E. Brown, Machika Kaku, John M. Coffin, Daria Wells, John K Yoon, Joseph R Holloway
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
In vivo clonal expansion of HIV-infected T cells is an important mechanism of viral persistence. In some cases, clonal expansion is driven by HIV proviral DNA integrated into one of a handful of genes. To investigate this phenomenon in vitro, we infe
Autor:
Joshua C. Cyktor, Wei Shao, Ann Wiegand, Elias K. Halvas, Daria Wells, John M. Coffin, Xiaolin Wu, Gert U. van Zyl, Jonathan Spindler, Mary Grace Katusiime, Mark F. Cotton, John W. Mellors, Stephen H. Hughes, Michael J. Bale, Mary F. Kearney
Publikováno v:
mBio
mBio, Vol 12, Iss 2 (2021)
mBio, Vol 12, Iss 2 (2021)
HIV-1 integrates its genome into the DNA of host cells. Consequently, HIV-1 genomes are copied with the host cell DNA during cellular division.
Little is known about the emergence and persistence of human immunodeficiency virus (HIV)-infected T-
Little is known about the emergence and persistence of human immunodeficiency virus (HIV)-infected T-
Autor:
Wei Shao, John M. Coffin, Stephen H. Hughes, Daria Wells, Michele D. Sobolewski, Xiaolin Wu, Jennifer M. Zerbato, Twan Sia, Frank Maldarelli, Michael J. Bale, John W. Mellors, Shuang Guo, Brian T. Luke, Mary F. Kearney
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009141 (2021)
PLoS Pathogens
PLoS Pathogens
HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART. To better understand what controls HIV persistence and the distribution of
Autor:
Michele D. Sobolewskii, Shuang Guo, Wei Shao, John M. Coffin, Michael J. Bale, Jennifer M. Zerbato, Brian T. Luke, Frank Maldarelli, Mary F. Kearney, Xiaolin Wu, Daria Wells, John W. Mellors, Twan Sia, Stephen H. Hughes
HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART. To better understand what controls HIV persistence and the distribution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e33a876bfde7d4ec6be45e197aa590e7
https://doi.org/10.1101/2020.11.25.397653
https://doi.org/10.1101/2020.11.25.397653
Autor:
Michael J. Bale, Xiaolin Wu, Joshua C. Cyktor, Wei Shao, Mark F. Cotton, Daria Wells, Mary Grace Katusiime, John M. Coffin, John W. Mellors, Stephen H. Hughes, Gert U. van Zyl, Ann Wiegand, Elias K. Halvas, Jonathan Spindler, Mary F. Kearney
Little is known about the emergence and persistence of HIV-infected T cell clones in perinatally-infected children. We analyzed peripheral blood mononuclear cells for clonal expansion in 11 children who initiated antiretroviral therapy (ART) between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af0f8e5c7477a0253daff4a4ae82e05
https://doi.org/10.1101/2020.09.15.298406
https://doi.org/10.1101/2020.09.15.298406