Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension

Autor: Markus M. Rinschen, Oleg Palygin, Ashraf El-Meanawy, Xavier Domingo-Almenara, Amelia Palermo, Lashodya V. Dissanayake, Daria Golosova, Michael A. Schafroth, Carlos Guijas, Fatih Demir, Johannes Jaegers, Megan L. Gliozzi, Jingchuan Xue, Martin Hoehne, Thomas Benzing, Bernard P. Kok, Enrique Saez, Markus Bleich, Nina Himmerkus, Ora A. Weisz, Benjamin F. Cravatt, Marcus Krüger, H. Paul Benton, Gary Siuzdak, Alexander Staruschenko

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Kidney metabolism in disease is important but not well understood. Here, using isotope-guided metabolomics, the authors show that lysine’s metabolic activity conveys kidney protection in hypertension through accelerated metabolism and physiological

Externí odkaz: https://doaj.org/article/2e9849a398d242b7a32232ec6d46f7d8

Regulation of Renin-Angiotensin System Activity and Blood Pressure by Vascular Smooth Muscle Cullin-3

Autor: Daria Golosova, Daniel Brozoski, Ko-Ting Lu, Patricia Muskus Veitia, Gaurav Kumar, Curt Sigmund

Publikováno v: Physiology. 38

Mutations in the ubiquitin ligase scaffold protein Cullin 3 (CUL3) in smooth muscle cells (SMCs) cause vascular dysfunction, arterial stiffness, and severe hypertension. We hypothesized that conditional deletion of CUL3 in SMCs causes severe hyperten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de0af47e2e5fb2ad90255b536c043d2c
https://doi.org/10.1152/physiol.2023.38.s1.5731421

Abstract 091: Does Smooth Muscle Cullin-3 Regulate The Renin-angiotensin System?

Autor: Daria Golosova, Daniel T Brozoski, Patricia Muskus Veitia, Ko-ting Lu, Curt D Sigmund

Publikováno v: Hypertension. 79

Cullin-3 (CUL3) is a scaffold protein involved in the formation and function of the CUL3-RING E3 ubiquitin ligase complex. Loss of smooth muscle CUL3 promotes vascular dysfunction, arterial stiffness, and severe hypertension (HTN). We hypothesized th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d9befb82d686e570089fd801743b2d3
https://doi.org/10.1161/hyp.79.suppl_1.091

Vibrodissociation method for isolation of defined nephron segments from human and rodent kidneys

Autor: Sherif Khedr, Ashraf El-Meanawy, Vladislav Levchenko, Oleg Palygin, Mykhailo Fedoriuk, Alexander Staruschenko, Elena Isaeva, Christine A. Klemens, Daria Golosova, Ruslan Bohovyk

Publikováno v: Am J Physiol Renal Physiol

Our current knowledge of the properties of renal ion channels responsible for electrolytes and cell energy homeostasis mainly relies on rodent studies. However, it has not been established yet to what extent their characteristics can be generalized t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a136d2a1cb23ed0005d0f18fd8e788be
https://doi.org/10.1152/ajprenal.00448.2019

Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension

Autor: Markus M. Rinschen, Oleg Palygin, Ashraf El-Meanawy, Xavier Domingo-Almenara, Amelia Palermo, Lashodya V. Dissanayake, Daria Golosova, Michael A. Schafroth, Carlos Guijas, Fatih Demir, Johannes Jaegers, Megan L. Gliozzi, Jingchuan Xue, Martin Hoehne, Thomas Benzing, Bernard P. Kok, Enrique Saez, Markus Bleich, Nina Himmerkus, Ora A. Weisz, Benjamin F. Cravatt, Marcus Krüger, H. Paul Benton, Gary Siuzdak, Alexander Staruschenko

Publikováno v: Rinschen, M M, Palygin, O, El-Meanawy, A, Domingo-Almenara, X, Palermo, A, Dissanayake, L V, Golosova, D, Schafroth, M A, Guijas, C, Demir, F, Jaegers, J, Gliozzi, M L, Xue, J, Hoehne, M, Benzing, T, Kok, B P, Saez, E, Bleich, M, Himmerkus, N, Weisz, O A, Cravatt, B F, Krüger, M, Benton, H P, Siuzdak, G & Staruschenko, A 2022, ' Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension ', Nature Communications, vol. 13, no. 1, 4099 . https://doi.org/10.1038/s41467-022-31670-0

Hypertension and kidney disease have been repeatedly associated with genomic variants and alterations of lysine metabolism. Here, we combined stable isotope labeling with untargeted metabolomics to investigate lysine’s metabolic fate in vivo. Dieta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4038910596e82962c99ef5d32e19d1
https://pubmed.ncbi.nlm.nih.gov/35835746