Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Daria Galas‐Filipowicz"'
Autor:
Daria Galas-Filipowicz, Selina J. Chavda, Jia-Nan Gong, David C. S. Huang, Asim Khwaja, Kwee Yong
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionBCL-2 family proteins are important for tumour cell survival and drug resistance in multiple myeloma (MM). Although proteasome inhibitors are effective anti-myeloma drugs, some patients are resistant and almost all eventually relapse. We
Externí odkaz:
https://doaj.org/article/3f533fcbf74447e289791076e3a6c8ea
Autor:
Houfu Leng, Hanlin Zhang, Linsen Li, Shuhao Zhang, Yanping Wang, Selina J. Chavda, Daria Galas-Filipowicz, Hantao Lou, Adel Ersek, Emma V. Morris, Erdinc Sezgin, Yi-Hsuan Lee, Yunsen Li, Ana Victoria Lechuga-Vieco, Mei Tian, Jian-Qing Mi, Kwee Yong, Qing Zhong, Claire M. Edwards, Anna Katharina Simon, Nicole J. Horwood
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here, the authors show that the glycosylceramide synthesis inhibitor and FDA approved drug Eliglustat inhibits autophagic degradation of TRAF3 which is a key step for osteoclast differentiation and thereby improves myeloma bone lesions.
Externí odkaz:
https://doaj.org/article/d3f4b2b671d34e5f9416142c53caf80d
Autor:
Simon Thomas, Julia Taylor, Manuel Rodriguez-Justo, Kwee Yong, Mathieu Ferrari, Shimobi Onuoha, Sonja Zweegman, Rakesh Popat, Lydia Lee, Wen Chean Lim, Daria Galas-Filipowicz, Kent Fung, Dominic Patel, Zulaikha Akbar, Elena Alvarez Mediavilla, Patrycja Wawrzyniecka, Debarati Shome, Rogier M Reijmers, Trillian Gregg, Leigh Wood, William Day, Virginie Cerec, Shaun Cordoba, Nushmia Khokhar, Vijay Peddareddigari, Muhammad Al-Hajj, Jim Cavet, Martin Pule
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background We used a proliferating ligand (APRIL) to construct a ligand-based third generation chimeric antigen receptor (CAR) able to target two myeloma antigens, B-cell maturation antigen (BCMA) and transmembrane activator and CAML interactor.Metho
Externí odkaz:
https://doaj.org/article/8067650d1c374058a81e8dfb09c80620
Autor:
Lydia Lee, Nouf Alrasheed, Garima Khandelwal, Evelyn Fitzsimons, Huw Richards, William Wilson, Selina J. Chavda, Jake Henry, Lucia Conde, Marc Robert De Massy, Melody Chin, Daria Galas-Filipowicz, Javier Herrero, Benny Chain, Sergio A. Quezada, Kwee Yong
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The benefit of autologous stem cell transplantation (ASCT) in newly diagnosed myeloma patients, apart from supporting high dose chemotherapy, may include effects on T cell function in the bone marrow (BM). We report our exploratory findings on marrow
Externí odkaz:
https://doaj.org/article/d972c67f22ad4807be9e90d8f32e8051
Autor:
Ieuan G Walker, Venetia D’arcy, Garima Khandelwal, Georgina Anderson, Anna Aubareda, William Wilson, Evelyn Fitzsimons, Daria Galas-Filipowicz, Kane Foster, Rakesh Popat, Karthik Ramasamy, Matthew Streetly, Ceri Bygrave, Reuben Benjamin, Ruth M. de Tute, Marquita Camilleri, Selina J Chavda, Gavin Pang, Tushhar Dadaga, Sumaiya Kamora, James Cavenagh, Elizabeth H. Phillips, Laura Clifton-Hadley, Roger G Owen, Javier Herrero, Kwee Yong, Michael A Chapman
Precision medicine holds great promise to improve outcomes in cancer, including haematological malignancies. However, there are few biomarkers that influence choice of chemotherapy in clinical practice. In particular, multiple myeloma requires an ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46977ce949893d3764e80ba006136b09
https://doi.org/10.1101/2023.04.08.23288287
https://doi.org/10.1101/2023.04.08.23288287
Autor:
Kwee L. Yong, Sergio A. Quezada, Javier Herrero, Martin Pule, Manuel Rodriguez-Justo, Anthony Brooks, Dominic Patel, Oliver C. Cohen, Dunnya De-Silva, Huw Richards, Selina J. Chavda, Andrew J.S. Furness, Daria Galas-Filipowicz, Melody Chin, Lucia Conde, Jake Y. Henry, Ehsan Ghorani, Lydia Lee, Nouf Alrasheed
Purpose:Immune dysregulation is described in multiple myeloma. While preclinical models suggest a role for altered T-cell immunity in disease progression, the contribution of immune dysfunction to clinical outcomes remains unclear. We aimed to charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ae590a362cc2c1903d91f6a3589fbc
https://doi.org/10.1158/1078-0432.c.6528762.v1
https://doi.org/10.1158/1078-0432.c.6528762.v1
Autor:
Kwee L. Yong, Sergio A. Quezada, Javier Herrero, Martin Pule, Manuel Rodriguez-Justo, Anthony Brooks, Dominic Patel, Oliver C. Cohen, Dunnya De-Silva, Huw Richards, Selina J. Chavda, Andrew J.S. Furness, Daria Galas-Filipowicz, Melody Chin, Lucia Conde, Jake Y. Henry, Ehsan Ghorani, Lydia Lee, Nouf Alrasheed
Supplementary tables and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2847b1021ef16d14d91d85918f959571
https://doi.org/10.1158/1078-0432.22474356.v1
https://doi.org/10.1158/1078-0432.22474356.v1
Autor:
Annabel McMillan, Thien‐An Tran, Daria Galas‐Filipowicz, Marquita Camilleri, Catherine Lecat, Louise Ainley, Yanping Guo, Kwee Yong, Jonathan Sive
Publikováno v:
Cytometry. Part B, Clinical cytometryREFERENCES.
Achieving minimal residual disease (MRD) negativity following treatment for multiple myeloma (MM) is associated with improved progression free and overall survival. In the UK, MRD assessments in MM are not incorporated into routine clinical use outsi
Autor:
Ieuan Walker, Venetia D'arcy, Antonio Rodriguez Romera, Georgina Anderson, Anna Aubareda, James Roy, Garima Khandelwal, William Wilson, Evelyn Fitzsimons, Daria Galas-Filipowicz, Kane Foster, Rakesh Popat, Karthik Ramasamy, Matthew Streetly, Ceri Bygrave, Reuben Benjamin, Ruth M. de Tute, Marquita Camilleri, Selina J Chavda, Gavin Pang, Tushhar Dadaga, Sumaiya Kamora, James Cavenagh, Elizabeth H. Phillips, Laura Clifton-Hadley, Roger G Owen, Javier Herrero, Kwee Yong, Michael A Chapman
Publikováno v:
Blood. 140:10106-10107
Autor:
Ieuan Walker, Garima Khandelwal, Venetia D’Arcy, William Wilson, Evie Fitzsimons, Daria Galas-Filipowicz, Rakesh Popat, Karthik Ramasamy, Matthew Streetly, Ceri Bygrave, Reuben Benjamin, Ruth de Tute, Marquita Camilleri, Selina Chavda, Gavin Pang, Richard Jenner, Tushhar Dadaga, Sumaiya Kamora, James Cavenagh, Laura Clifton-Hadley, Roger Owen, Javier Herrero, Kwee Yong, Michael Chapman
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S11-S12