Germ Line/Multipotency Genes Show Differential Expression during Embryonic Development of the Annelid Enchytraeus coronatus

Autor: Roman P. Kostyuchenko, Daria D. Nikanorova, Artem V. Amosov

Publikováno v: Biology, Vol 12, Iss 12, p 1508 (2023)

Germ line development and the origin of the primordial germ cells (PGCs) are very variable and may occur across a range of developmental stages and in several developmental contexts. In establishing and maintaining germ line, a conserved set of genes

Externí odkaz: https://doaj.org/article/7e73e805049b4b829783d69f20e854f6

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.

Autor: Jones-Tabah J; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada., He K; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada., Karpilovsky N; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada., Senkevich K; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada., Deyab G; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada., Pietrantonio I; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada., Goiran T; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada., Cousineau Y; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada., Nikanorova D; Research Department, Bioinformatics Institute, Saint-Petersburg, Russia., Goldsmith T; Early Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Del Cid Pellitero E; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada., Chen CX; Early Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Luo W; Early Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., You Z; Early Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Abdian N; Early Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Ahmad J; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada., Ruskey JA; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada., Asayesh F; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.; Department of Human Genetics, McGill University, Montréal, Canada., Spiegelman D; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada., Fahn S; Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA., Waters C; Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA., Monchi O; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada.; Département de Radiologie, Radio-Oncologie Et Médecine Nucléaire, Université de Montréal, Montréal, QC, Canada.; Centre de Recherche de L'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada., Dauvilliers Y; Sleep Unit, Department of Neurology, National Reference Center for Narcolepsy, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Montpellier, France., Dupré N; Neuroscience Axis, CHU de Québec - Université Laval, , Quebec City, G1V 4G2, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Québec, QC, G1V 0A6, Canada., Miliukhina I; Institute of the Human Brain of RAS, St. Petersburg, Russia., Timofeeva A; First Pavlov State Medical, University of St. Petersburg, Saint-Petersburg, Russia., Emelyanov A; First Pavlov State Medical, University of St. Petersburg, Saint-Petersburg, Russia., Pchelina S; First Pavlov State Medical, University of St. Petersburg, Saint-Petersburg, Russia., Greenbaum L; Institute of the Human Brain of RAS, St. Petersburg, Russia.; First Pavlov State Medical, University of St. Petersburg, Saint-Petersburg, Russia.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Hassin-Baer S; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.; Department of Neurology, The Movement Disorders Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel., Alcalay RN; Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.; Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Milnerwood A; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada., Durcan TM; Early Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Gan-Or Z; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.; Department of Human Genetics, McGill University, Montréal, Canada., Fon EA; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada. ted.fon@mcgill.ca.; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada. ted.fon@mcgill.ca.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2024 Nov 25; Vol. 19 (1), pp. 88. Date of Electronic Publication: 2024 Nov 25.

GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease.

Autor: Senkevich K; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal H3A 2B4, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal H3A 2B4, Canada., Zorca CE; Department of Neurology and Neurosurgery, McGill University, Montréal H3A 2B4, Canada.; Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal H3A 2B4, Canada., Dworkind A; Department of Physiology, McGill University, Montréal H3A 1A1, Canada., Rudakou U; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal H3A 2B4, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal H3A 2B4, Canada.; Department of Human Genetics, McGill University, Montréal H3A 1A1, Canada., Somerville E; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal H3A 2B4, Canada.; Department of Human Genetics, McGill University, Montréal H3A 1A1, Canada., Yu E; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal H3A 2B4, Canada.; Department of Human Genetics, McGill University, Montréal H3A 1A1, Canada., Ermolaev A; Center of Molecular Biotechnology, Russian State Agrarian University-Moscow Timiryazev Agricultural Academy, Moscow 127550, Russia.; ȃResearch Department, Bioinformatics Institute, Saint-Petersburg 194100, Russia., Nikanorova D; ȃResearch Department, Bioinformatics Institute, Saint-Petersburg 194100, Russia., Ahmad J; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal H3A 2B4, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal H3A 2B4, Canada., Ruskey JA; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal H3A 2B4, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal H3A 2B4, Canada., Asayesh F; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal H3A 2B4, Canada.; Department of Human Genetics, McGill University, Montréal H3A 1A1, Canada., Spiegelman D; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal H3A 2B4, Canada., Fahn S; Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032-3784, USA., Waters C; Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032-3784, USA., Monchi O; Department of Neurology and Neurosurgery, McGill University, Montréal H3A 2B4, Canada.; Department of Clinical Neurosciences and Department of Radiology, University of Calgary, Calgary T2N 1N4, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, Calgary T2N 4N1, Canada., Dauvilliers Y; ȃNational Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, 34090 Montpellier, France., Dupré N; Neuroscience Axis, CHU de Québec-Université Laval, Quebec City G1V 4G2, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Québec G1V 0A6, Canada., Greenbaum L; ȃThe Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer 52621, Israel.; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer 52621, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel., Hassin-Baer S; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.; Department of Neurology, The Movement Disorders Institute, Sheba Medical Center, Tel Hashomer 52621, Israel., Grenn FP; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA., Chiang MSR; Rare and Neurologic Diseases Therapeutic Area, Sanofi, Framingham, MA 01701, USA., Sardi SP; Rare and Neurologic Diseases Therapeutic Area, Sanofi, Framingham, MA 01701, USA., Vanderperre B; Département des sciences biologiques, Université du Québec à Montréal, Montréal H2X 1Y4, Canada., Blauwendraat C; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA., Trempe JF; Department of Pharmacology and Therapeutics and Centre de Recherche en Biologie Structurale, McGill University, Montreal H3A 1A3, Canada., Fon EA; Department of Neurology and Neurosurgery, McGill University, Montréal H3A 2B4, Canada.; Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal H3A 2B4, Canada., Durcan TM; Early Drug Discovery Unit (EDDU), Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal H3A 2B4, Canada., Alcalay RN; Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032-3784, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA., Gan-Or Z; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal H3A 2B4, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal H3A 2B4, Canada.; Department of Human Genetics, McGill University, Montréal H3A 1A1, Canada.

Publikováno v: Brain : a journal of neurology [Brain] 2023 May 02; Vol. 146 (5), pp. 1859-1872.