Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Daria, Merkurjev"'
Autor:
Mel·lina Pinsach-Abuin, Bernat del Olmo, Adrian Pérez-Agustin, Jesus Mates, Catarina Allegue, Anna Iglesias, Qi Ma, Daria Merkurjev, Sergiy Konovalov, Jing Zhang, Farah Sheikh, Amalio Telenti, Josep Brugada, Ramon Brugada, Melissa Gymrek, Julia di Iulio, Ivan Garcia-Bassets, Sara Pagans
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100250- (2021)
Summary: Genome-wide association studies (GWASs) are instrumental in identifying loci harboring common single-nucleotide variants (SNVs) that affect human traits and diseases. GWAS hits emerge in clusters, but the focus is often on the most significa
Externí odkaz:
https://doaj.org/article/6c838ad5069a44029f4b3ea3f35643c1
Autor:
Kristiyana, Kaneva, Theodore G, Schurr, Tatiana V, Tatarinova, Jonathan, Buckley, Daria, Merkurjev, Petr, Triska, Xiyu, Liu, James, Done, Dennis T, Maglinte, Dennis, Deapen, Amie, Hwang, Joshua D, Schiffman, Timothy J, Triche, Jaclyn A, Biegel, Xiaowu, Gai
Publikováno v:
Mitochondrion. 67:6-14
Based on current studies, the incidence of Ewing sarcoma (ES) varies significantly by race and ethnicity, with the disease being most common in patients of European ancestry. However, race/ethnicity has generally been self-reported rather than formal
Autor:
Qi Ma, Feng Yang, Carlos Mackintosh, Ranveer Singh Jayani, Soohwan Oh, Chunyu Jin, Sreejith Janardhanan Nair, Daria Merkurjev, Wubin Ma, Stephanie Allen, Dong Wang, Angels Almenar-Queralt, Ivan Garcia-Bassets
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Cisplatin is an antineoplastic drug administered at suboptimal and intermittent doses to avoid life-threatening effects. Although this regimen shortly improves symptoms in the short term, it also leads to more malignant disease in the long t
Externí odkaz:
https://doaj.org/article/50ac903137cb4210b15ac40955ec50f1
Autor:
Thuc M. Le, Soumya Poddar, Joseph R. Capri, Evan R. Abt, Woosuk Kim, Liu Wei, Nhu T. Uong, Chloe M. Cheng, Daniel Braas, Mina Nikanjam, Peter Rix, Daria Merkurjev, Jesse Zaretsky, Harley I. Kornblum, Antoni Ribas, Harvey R. Herschman, Julian Whitelegge, Kym F. Faull, Timothy R. Donahue, Johannes Czernin, Caius G. Radu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Leukemic cells depend on the nucleotide synthesis pathway to proliferate. Here the authors use metabolomics and proteomics to show that inhibition of ATR reduced the activity of these pathways thus providing a valuable therapeutic target in leukemia.
Externí odkaz:
https://doaj.org/article/ea735642f5484b8db7d0f34fe2f452fc
Autor:
Xiaowu Gai, Jaclyn A. Biegel, Timothy J. Triche, Marni J. Falk, Noor Sohail, Daria Merkurjev, Kristiyana Kaneva, Petr Triska
Supplementary Figure 3 illustrates how the observed dN/dS ratio varies by the heteroplasmy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbd31c15e16acccb5a4d97b023fcbd2
https://doi.org/10.1158/0008-5472.22421817.v1
https://doi.org/10.1158/0008-5472.22421817.v1
Autor:
Xiaowu Gai, Jaclyn A. Biegel, Timothy J. Triche, Marni J. Falk, Noor Sohail, Daria Merkurjev, Kristiyana Kaneva, Petr Triska
Supplementary Figure 2 illustrates that individual tumor cells showing the same mtDNA variants at different heteroplasmy levels as exhibited by the bulk tumor samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9accf46796f71aa7e553b517bd0aeed
https://doi.org/10.1158/0008-5472.22421820.v1
https://doi.org/10.1158/0008-5472.22421820.v1
Autor:
Xiaowu Gai, Jaclyn A. Biegel, Timothy J. Triche, Marni J. Falk, Noor Sohail, Daria Merkurjev, Kristiyana Kaneva, Petr Triska
Figure Legends for Supplementary Figures 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b334932dfdc34f92cd0ceec56592ed6a
https://doi.org/10.1158/0008-5472.22421805
https://doi.org/10.1158/0008-5472.22421805
Autor:
Xiaowu Gai, Jaclyn A. Biegel, Timothy J. Triche, Marni J. Falk, Noor Sohail, Daria Merkurjev, Kristiyana Kaneva, Petr Triska
Supplementary Figure 1 illustrates single-cell ATAC-seq data contains sufficient mtDNA reads for interrogating mtDNA variants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02efd8a609a6d53c53b009b6449e1472
https://doi.org/10.1158/0008-5472.22421823.v1
https://doi.org/10.1158/0008-5472.22421823.v1
Autor:
Xiaowu Gai, Jaclyn A. Biegel, Timothy J. Triche, Marni J. Falk, Noor Sohail, Daria Merkurjev, Kristiyana Kaneva, Petr Triska
Supplementary Figure 5 illustrates that mtDNA mutations in the mtDNA hypermutated pediatric tumor samples tend to occur at low heteroplasmy levels and are more likely to be benign in nature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d52e8e8b7b12a16fe4696d36bb90f5c
https://doi.org/10.1158/0008-5472.22421811
https://doi.org/10.1158/0008-5472.22421811
Autor:
Xiaowu Gai, Jaclyn A. Biegel, Timothy J. Triche, Marni J. Falk, Noor Sohail, Daria Merkurjev, Kristiyana Kaneva, Petr Triska
Supplementary Figure 6 show the distributions of the heteroplasmy levels of mtDNA mutations, depending on the gene and the location affected.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff67fbdf7a60be14ece13a267d10857
https://doi.org/10.1158/0008-5472.22421808
https://doi.org/10.1158/0008-5472.22421808