Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Daret K. St. Clair"'
Hydrogen Peroxide Promotes the Production of Radiation-Derived EVs Containing Mitochondrial Proteins
Autor:
Caitlin E. Miller, Fangfang Xu, Yanming Zhao, Wei Luo, Weixiong Zhong, Kristy Meyer, Rani Jayswal, Heidi L. Weiss, William H. St. Clair, Daret K. St. Clair, Luksana Chaiswing
Publikováno v:
Antioxidants, Vol 11, Iss 11, p 2119 (2022)
In spite of extensive successes, cancer recurrence after radiation treatment (RT) remains one of the significant challenges in the cure of localized prostate cancer (PCa). This study focuses on elucidating a novel adaptive response to RT that could c
Externí odkaz:
https://doaj.org/article/b36859d375574e75a78a63fbca9bb225
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1194 (2022)
Oxidative stress plays a significant role in cancer development and cancer therapy, and is a major contributor to normal tissue injury. The unique characteristics of extracellular vesicles (EVs) have made them potentially useful as a diagnostic tool
Externí odkaz:
https://doaj.org/article/6973e1a30e2b4e4a926c448c34444e37
Autor:
Chontida Yarana, Hannah Thompson, Luksana Chaiswing, D. Allan Butterfield, Heidi Weiss, Subbarao Bondada, Sara Alhakeem, Suriyan Sukati, Daret K. St. Clair
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Extracellular vesicles (EVs) generated from redox active anticancer drugs are released into the extracellular environment. These EVs contain oxidized molecules and trigger inflammatory responses by macrophages. Using a mouse model of doxorubicin (DOX
Externí odkaz:
https://doaj.org/article/98e908279b00465d8862dbf696cd086c
Publikováno v:
International Journal of Molecular Sciences, Vol 12, Iss 10, Pp 7114-7162 (2011)
The mitochondrion is vital for many metabolic pathways in the cell, contributing all or important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the urea cycle, the citric acid cycle, and ATP synthesis. The mitochondri
Externí odkaz:
https://doaj.org/article/185a2d04a3f243b4b391cc6986b05d96
Autor:
Jitbanjong Tangpong, Marsha P. Cole, Rukhsana Sultana, Gururaj Joshi, Steven Estus, Mary Vore, William St. Clair, Suvina Ratanachaiyavong, Daret K. St. Clair, D. Allan Butterfield
Publikováno v:
Neurobiology of Disease, Vol 23, Iss 1, Pp 127-139 (2006)
The clinical effectiveness of adriamycin (ADR), a potent chemotherapeutic, is known to be limited by severe cardiotoxic side effects. However, the effect of ADR on brain tissue is not well understood. It is generally thought that ADR is not toxic to
Externí odkaz:
https://doaj.org/article/0a3912b7faeb49c4b884838944348268
Autor:
Chontida Yarana, Daret K. St. Clair
Publikováno v:
Antioxidants, Vol 6, Iss 4, p 75 (2017)
The short- and long-term side effects of chemotherapy limit the maximum therapeutic dose and impair quality of life of survivors. Injury to normal tissues, especially chemotherapy-induced cardiomyopathy, is an unintended outcome that presents devasta
Externí odkaz:
https://doaj.org/article/4d4f918d4061418eb99d7caa98bebff4
Autor:
Daret K. St. Clair, Haining Zhu, D. Allan Butterfield, Jeffrey A. Moscow, Emily V. Dressler, Younsoo Bae, Michael Alstott, Teresa Noel, Yanming Zhao, Luksana Chaiswing, Jing Chen, Dustin Carroll, Chontida Yarana
Western blots indicating PYGB, PYGM, and PYGL are tissue-specific protein. PYGB is highly expressed in heart and brain. PYGM is highly expressed in skeletal muscle. PYGL is highly expressed in liver. Vinculin and tubulin were used as appropriate posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fea728dcda5d7f7f893dd10818d90b
https://doi.org/10.1158/1078-0432.22464719.v1
https://doi.org/10.1158/1078-0432.22464719.v1
Autor:
Daret K. St. Clair, Haining Zhu, D. Allan Butterfield, Jeffrey A. Moscow, Emily V. Dressler, Younsoo Bae, Michael Alstott, Teresa Noel, Yanming Zhao, Luksana Chaiswing, Jing Chen, Dustin Carroll, Chontida Yarana
Western blots display PYGB, PYGM, and PYGL expression. A. EVs from mice treated with saline or DOX. B. PYGB in EVs and heart tissues from wild-type or MnSOD Tg mice treated with saline or DOX. C. PYGB in EVs and heart tissues from mice treated with M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd61faf3794f9b6c272feb12687f7c3
https://doi.org/10.1158/1078-0432.22464710.v1
https://doi.org/10.1158/1078-0432.22464710.v1
Autor:
William H. St. Clair, Daret K. St. Clair, Jinfei Chen, Chi Wang, Teresa Noel, David Schnell, Luksana Chaiswing, Fang Fang Xu, Yong Xu, Xiaowei Wei
Cancer cells typically experience higher oxidative stress than normal cells, such that elevating pro-oxidant levels can trigger cancer cell death. Although pre-exposure to mild oxidative agents will sensitize cancer cells to radiation, this pre-expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3c22f3da7f1742c51643c3052409c5
https://doi.org/10.1158/0008-5472.c.6509657.v1
https://doi.org/10.1158/0008-5472.c.6509657.v1
Autor:
Daret K. St. Clair, Haining Zhu, D. Allan Butterfield, Jeffrey A. Moscow, Emily V. Dressler, Younsoo Bae, Michael Alstott, Teresa Noel, Yanming Zhao, Luksana Chaiswing, Jing Chen, Dustin Carroll, Chontida Yarana
Sucrose gradient isolation process for proteomics analysis. A. Diagram showing the process of EV isolation by sucrose gradient method. B. Western blots of EV markers, CD63 and CD81 of sucrose gradient fraction 1 to 5 (from the top to the bottom). C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52411e5ce76bed977078f08ddecb16d5
https://doi.org/10.1158/1078-0432.22464725.v1
https://doi.org/10.1158/1078-0432.22464725.v1