Zobrazeno 1 - 10
of 362
pro vyhledávání: '"Daret K. St. Clair"'
Autor:
Daisuke Masuda, Ikuo Nakanishi, Kei Ohkubo, Hiromu Ito, Ken-ichiro Matsumoto, Hiroshi Ichikawa, Moragot Chatatikun, Wiyada Kwanhian Klangbud, Manas Kotepui, Motoki Imai, Fumitaka Kawakami, Makoto Kubo, Hirofumi Matsui, Jitbanjong Tangpong, Takafumi Ichikawa, Toshihiko Ozawa, Hsiu-Chuan Yen, Daret K. St Clair, Hiroko P. Indo, Hideyuki J. Majima
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 128 (2024)
Questions about which reactive oxygen species (ROS) or reactive nitrogen species (RNS) can escape from the mitochondria and activate signals must be addressed. In this study, two parameters, the calculated dipole moment (debye, D) and permeability co
Externí odkaz:
https://doaj.org/article/2f9fcb72f1c247bc85463ff752e569d2
Hydrogen Peroxide Promotes the Production of Radiation-Derived EVs Containing Mitochondrial Proteins
Autor:
Caitlin E. Miller, Fangfang Xu, Yanming Zhao, Wei Luo, Weixiong Zhong, Kristy Meyer, Rani Jayswal, Heidi L. Weiss, William H. St. Clair, Daret K. St. Clair, Luksana Chaiswing
Publikováno v:
Antioxidants, Vol 11, Iss 11, p 2119 (2022)
In spite of extensive successes, cancer recurrence after radiation treatment (RT) remains one of the significant challenges in the cure of localized prostate cancer (PCa). This study focuses on elucidating a novel adaptive response to RT that could c
Externí odkaz:
https://doaj.org/article/b36859d375574e75a78a63fbca9bb225
Publikováno v:
Antioxidants, Vol 11, Iss 6, p 1194 (2022)
Oxidative stress plays a significant role in cancer development and cancer therapy, and is a major contributor to normal tissue injury. The unique characteristics of extracellular vesicles (EVs) have made them potentially useful as a diagnostic tool
Externí odkaz:
https://doaj.org/article/6973e1a30e2b4e4a926c448c34444e37
Autor:
Sudha Sharma, Susmita Bhattarai, Hosne Ara, Grace Sun, Daret K. St Clair, Md Shenuarin Bhuiyan, Christopher Kevil, Megan N. Watts, Paari Dominic, Takahiko Shimizu, Kevin J. McCarthy, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101740- (2020)
Electrophilic aldehyde (4-hydroxynonenal; 4-HNE), formed after lipid peroxidation, is a mediator of mitochondrial dysfunction and implicated in both the pathogenesis and the progression of cardiovascular disease. Manganese superoxide dismutase (MnSOD
Externí odkaz:
https://doaj.org/article/2e80799244c74b9aa7443b34abaa0a5a
Autor:
Chontida Yarana, Hannah Thompson, Luksana Chaiswing, D. Allan Butterfield, Heidi Weiss, Subbarao Bondada, Sara Alhakeem, Suriyan Sukati, Daret K. St. Clair
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Extracellular vesicles (EVs) generated from redox active anticancer drugs are released into the extracellular environment. These EVs contain oxidized molecules and trigger inflammatory responses by macrophages. Using a mouse model of doxorubicin (DOX
Externí odkaz:
https://doaj.org/article/98e908279b00465d8862dbf696cd086c
Autor:
Daret K. St. Clair, Haining Zhu, D. Allan Butterfield, Jeffrey A. Moscow, Emily V. Dressler, Younsoo Bae, Michael Alstott, Teresa Noel, Yanming Zhao, Luksana Chaiswing, Jing Chen, Dustin Carroll, Chontida Yarana
Western blots indicating PYGB, PYGM, and PYGL are tissue-specific protein. PYGB is highly expressed in heart and brain. PYGM is highly expressed in skeletal muscle. PYGL is highly expressed in liver. Vinculin and tubulin were used as appropriate posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fea728dcda5d7f7f893dd10818d90b
https://doi.org/10.1158/1078-0432.22464719.v1
https://doi.org/10.1158/1078-0432.22464719.v1
Autor:
Daret K. St. Clair, Haining Zhu, D. Allan Butterfield, Jeffrey A. Moscow, Emily V. Dressler, Younsoo Bae, Michael Alstott, Teresa Noel, Yanming Zhao, Luksana Chaiswing, Jing Chen, Dustin Carroll, Chontida Yarana
Western blots display PYGB, PYGM, and PYGL expression. A. EVs from mice treated with saline or DOX. B. PYGB in EVs and heart tissues from wild-type or MnSOD Tg mice treated with saline or DOX. C. PYGB in EVs and heart tissues from mice treated with M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd61faf3794f9b6c272feb12687f7c3
https://doi.org/10.1158/1078-0432.22464710.v1
https://doi.org/10.1158/1078-0432.22464710.v1
Autor:
William H. St. Clair, Daret K. St. Clair, Jinfei Chen, Chi Wang, Teresa Noel, David Schnell, Luksana Chaiswing, Fang Fang Xu, Yong Xu, Xiaowei Wei
Cancer cells typically experience higher oxidative stress than normal cells, such that elevating pro-oxidant levels can trigger cancer cell death. Although pre-exposure to mild oxidative agents will sensitize cancer cells to radiation, this pre-expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3c22f3da7f1742c51643c3052409c5
https://doi.org/10.1158/0008-5472.c.6509657.v1
https://doi.org/10.1158/0008-5472.c.6509657.v1
Autor:
Daret K. St. Clair, Haining Zhu, D. Allan Butterfield, Jeffrey A. Moscow, Emily V. Dressler, Younsoo Bae, Michael Alstott, Teresa Noel, Yanming Zhao, Luksana Chaiswing, Jing Chen, Dustin Carroll, Chontida Yarana
Sucrose gradient isolation process for proteomics analysis. A. Diagram showing the process of EV isolation by sucrose gradient method. B. Western blots of EV markers, CD63 and CD81 of sucrose gradient fraction 1 to 5 (from the top to the bottom). C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52411e5ce76bed977078f08ddecb16d5
https://doi.org/10.1158/1078-0432.22464725.v1
https://doi.org/10.1158/1078-0432.22464725.v1
Autor:
Daret K. St. Clair, Haining Zhu, D. Allan Butterfield, Jeffrey A. Moscow, Emily V. Dressler, Younsoo Bae, Michael Alstott, Teresa Noel, Yanming Zhao, Luksana Chaiswing, Jing Chen, Dustin Carroll, Chontida Yarana
Western blots confirming the existence of PYGB, PYGM, and PYGL in SAL_EVs and DOX_EVs after treatment with proteinase K. Cell lysate was used as a positive control for PYGB, PYGM and PYGL detection. IgG and albumin were measured as a reference for pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d262a9ef983c4733d0a56c262a0942
https://doi.org/10.1158/1078-0432.22464713
https://doi.org/10.1158/1078-0432.22464713