Výsledky vyhledávání - "Darerca Owen"

The Cdc42 effector and non-receptor tyrosine kinase, ACK defines a distinct STAT5 transcription signature in a chronic myeloid leukaemia cell model

Autor: Jessica Corry, Daniel Jachimowicz, Benjamin Keith, Jose Julio Vicente-Garcia, Helen R. Mott, Kate Wickson, Darerca Owen

SummaryActivated Cdc42-associated kinase (ACK) is a Rho family effector that is widely implicated in cancer. Here, we describe new roles for ACK in transcriptional regulation mediated by its relationship with the signal transducer and activators of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8dde889b7cbe66e54d72c6f719911f8
https://doi.org/10.1101/2022.06.10.494364

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A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases

Autor: Samrein B M Ahmed, Darerca Owen, Helen R. Mott, Matthew Harris, Nicola J Darling, Ana Masara Ahmad Mokhtar

Publikováno v: Biochemistry

There are three RhoGDIs in mammalian cells, which were initially defined as negative regulators of Rho family small GTPases. However, it is now accepted that RhoGDIs not only maintain small GTPases in their inactive GDP-bound form but also act as cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdeb4e76d0218872119df0940b676f7
https://doi.org/10.1021/acs.biochem.1c00120

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Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK

Autor: Natasha S. Clayton, Millie Fox, Jose J. Vicenté-Garcia, Courtney M. Schroeder, Trevor D. Littlewood, Jonathon I. Wilde, Kadalmani Krishnan, Murray J.B. Brown, Claire Crafter, Helen R. Mott, Darerca Owen

Activated Cdc42-associated kinase (ACK) is an oncogenic nonreceptor tyrosine kinase associated with poor prognosis in several human cancers. ACK promotes proliferation, in part by contributing to the activation of Akt, the major effector of class 1A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41be413a469124b50749c5c7e055601e

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Membrane extraction by calmodulin underpins the disparate signalling of RalA and RalB

Autor: Samuel G. Chamberlain, Darerca Owen, Helen R. Mott

Both RalA and RalB interact with the ubiquitous calcium sensor, calmodulin (CaM). New structural and biophysical characterisation of these interactions strongly suggests that, in the native membrane-associated state, only RalA can be extracted from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4e7328172fcad126018b8c44fb92e2

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Intrinsically disordered proteins and membranes: a marriage of convenience for cell signalling?

Autor: Helen R. Mott, Darerca Owen, Jasmine Cornish, Samuel G Chamberlain

Publikováno v: Biochemical Society Transactions

The structure-function paradigm has guided investigations into the molecules involved in cellular signalling for decades. The peripheries of this paradigm, however, start to unravel when considering the co-operation between proteins and the membrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b23c5e888c605f0383bbb066fc71d8
https://doi.org/10.1042/bst20200467

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Activation of STAT transcription factors by the Rho-family GTPases

Autor: Darerca Owen, Helen R. Mott, Jessica Corry

Publikováno v: Biochemical Society Transactions

The Rho-family of small GTPases are biological molecular switches that are best known for their regulation of the actin cytoskeleton. Through their activation and stimulation of downstream effectors, the Rho-family control pathways involved in cellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5959e61446c914b2c4bcb9bfa986bae8
https://doi.org/10.1042/bst20200468

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Calmodulin extracts the ras family protein rala from lipid bilayers by engagement with two membrane-targeting motifs

Autor: Darerca Owen, Arooj Shafiq, Iolo J Squires, Samuel G Chamberlain, Helen R. Mott, Andrea Gohlke

Publikováno v: Proc Natl Acad Sci U S A

RalA is a small GTPase and a member of the Ras family. This molecular switch is activated downstream of Ras and is widely implicated in tumor formation and growth. Previous work has shown that the ubiquitous Ca(2+)-sensor calmodulin (CaM) binds to sm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e452dff2a4de532bfad2211ebf1ea5
https://doi.org/10.1016/j.bpj.2022.11.382

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