Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Daren L Knoell"'
Autor:
Daniel N. Villageliu, Kelly C. Cunningham, Deandra R. Smith, Daren L. Knoell, Mason Mandolfo, Todd A. Wyatt, Derrick R. Samuelson
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Alcohol use is an independent risk factor for the development of bacterial pneumonia due, in part, to impaired mucus-facilitated clearance, macrophage phagocytosis, and recruitment of neutrophils. Alcohol consumption is also known to reduce
Externí odkaz:
https://doaj.org/article/b24db32e6ef64bb984d11f7fc9878577
Autor:
Charlie J Pyle, Saife Akhter, ShengYing Bao, Claire E Dodd, Larry S Schlesinger, Daren L Knoell
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169531 (2017)
Two vital functions of the innate immune system are to initiate inflammation and redistribute micronutrients in favor of the host. Zinc is an essential micronutrient used in host defense. The zinc importer ZIP8 is uniquely induced through stimulation
Externí odkaz:
https://doaj.org/article/93f6436bb5af4de295a98f09ed5ef54f
Autor:
Kruthika Sundaram, Mohd Akhlakur Rahman, Srabani Mitra, Daren L Knoell, Shireen A Woodiga, Samantha J King, Mark D Wewers
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161931 (2016)
Pneumococcal lung infections represent a major cause of death worldwide. Single nucleotide polymorphisms (SNPs) in the NFKBIZ gene, encoding the transcription factor IκBζ, are associated with increased susceptibility to invasive pneumococcal diseas
Externí odkaz:
https://doaj.org/article/f03265839ec1421f8694acd531504b82
Autor:
Ming-Jie Liu, Shengying Bao, Jessica R Napolitano, Dara L Burris, Lianbo Yu, Susheela Tridandapani, Daren L Knoell
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94934 (2014)
Sepsis rapidly activates the host inflammatory response and acute phase response. Severe sepsis, complicated by multiple organ failure, is associated with overwhelming inflammation and high mortality. We previously observed that zinc (Zn) deficiency
Externí odkaz:
https://doaj.org/article/5cd306c88a27494bac802782fec6483b
Autor:
Christopher D. Bauer, Deanna D. Mosley, Derrick R. Samuelson, Jill A. Poole, Deandra R. Smith, Daren L. Knoell, Todd A. Wyatt
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 843 (2024)
Agricultural workers exposed to organic dust from swine concentrated animal feeding operations (CAFOs) have increased chances of contracting chronic lung disease. Mucociliary clearance represents a first line of defense against inhaled dusts, but org
Externí odkaz:
https://doaj.org/article/bcba136cfdfd4b22a1b30960b7148d84
Autor:
Kelly C. Cunningham, Deandra R. Smith, Daniel N. Villageliú, Christi M. Ellis, Amanda E. Ramer-Tait, Jeffrey D. Price, Todd A. Wyatt, Daren L. Knoell, Mystera M. Samuelson, Patricia E. Molina, David A. Welsh, Derrick R. Samuelson
Publikováno v:
Cells, Vol 12, Iss 18, p 2267 (2023)
Preclinical studies have shown that chronic alcohol abuse leads to alterations in the gastrointestinal microbiota that are associated with behavior changes, physiological alterations, and immunological effects. However, such studies have been limited
Externí odkaz:
https://doaj.org/article/a8b96d662ac14c31a8d5d2a677a403f0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Manganese (Mn) and Zinc (Zn) are essential micronutrients whose concentration and location within cells are tightly regulated at the onset of infection. Two families of Zn transporters (ZIPs and ZnTs) are largely responsible for regulation of cytosol
Externí odkaz:
https://doaj.org/article/b4093ebd531647f4afe35a9db5bf1577
Autor:
Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Sabah Haq, Daniel N. Villageliú, Christi M. Ellis, Niaz Bahar Chowdhury, Amanda E. Ramer-Tait, Jeffrey D. Price, Daren L. Knoell
Publikováno v:
Pathogens, Vol 12, Iss 5, p 639 (2023)
Intestinal dysbiosis increases susceptibility to infection through the alteration of metabolic profiles, which increases morbidity. Zinc (Zn) homeostasis in mammals is tightly regulated by 24 Zn transporters. ZIP8 is unique in that it is required by
Externí odkaz:
https://doaj.org/article/862ee493c2ac4ac48fce70a169dd0eba
Autor:
Muna Sapkota, Daren L. Knoell
Publikováno v:
Journal of Immunology Research, Vol 2018 (2018)
Zinc is an essential micronutrient known to play a vital role in host defense against pathogens. Diets that are deficient in zinc lead to impaired immunity and delayed recovery from and worse outcomes following infection. Sustained insufficient zinc
Externí odkaz:
https://doaj.org/article/28513c3a90e74e46a3567c6d33ef1c70
Autor:
Ling Ding, Siyuan Tang, Weimin Tang, Deanna D. Mosley, Ao Yu, Diptesh Sil, Svetlana Romanova, Kristina L. Bailey, Daren L. Knoell, Todd A. Wyatt, David Oupický
Publikováno v:
Advanced science (Weinheim, Baden-Wurttemberg, Germany). 9(8)
Local pulmonary administration of therapeutic siRNA represents a promising approach to the treatment of lung fibrosis, which is currently hampered by inefficient delivery. Development of perfluorooctylbromide (PFOB) nanoemulsions as a way of improvin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28b8c41bae0e378f9b19d0e6fe3372a
https://pubmed.ncbi.nlm.nih.gov/34994102
https://pubmed.ncbi.nlm.nih.gov/34994102