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Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines.

Autor: Darcy Welch, Elliot Kahen, Brooke Fridley, Andrew S Brohl, Christopher L Cubitt, Damon R Reed

Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0222228 (2019)

Ewing Sarcoma (ES) is characterized by recurrent translocations between EWSR1 and members of the ETS family of transcription factors. The transcriptional activity of the fusion oncoprotein is dependent on interaction with the nucleosome remodeling an

Externí odkaz: https://doaj.org/article/c3bbc978931f43f881e091e9cd886658

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Neurofibromin level directs RAS pathway signaling and mediates sensitivity to targeted agents in malignant peripheral nerve sheath tumors

Autor: Andrew S. Brohl, Damon R. Reed, Yonghong O. Zhang, Darcy Welch, Jae K. Lee, Diana Yu, Jamie K. Teer, Margaret R. Wallace, Elliot Kahen, Yunyun Chen, Sean J. Yoder, Christopher L. Cubitt

Publikováno v: Oncotarget

Malignant peripheral nerve sheath tumor (MPNST) is a type of soft-tissue sarcoma strongly associated with dysfunction in neurofibromin; an inhibitor of the RAS pathway. We performed high-throughput screening of an array of FDA approved and promising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ae005fe157aa0abd6ede7d40940881
https://doi.org/10.18632/oncotarget.25181

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Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines

Autor: Elliot Kahen, Brooke L. Fridley, Andrew S. Brohl, Damon R. Reed, Darcy Welch, Christopher L. Cubitt

Publikováno v: PLoS ONE, Vol 14, Iss 9, p e0222228 (2019)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f361df2e4fddbffffc3d6776e70e27ab
https://doi.org/10.1371/journal.pone.0222228

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Abstract 3010: Osteosarcoma cell lines display both shared and unique vulnerabilities to 140 targeted small molecules with RNA-seq revealing putative mechanisms

Autor: Elliot J. Kahen, Darcy Welch, Jamie Teer, Andrew S. Brohl, Sean J. Yoder, Yonghong Zhang, Ling Cen, Damon Reed

Publikováno v: Cancer Research. 79:3010-3010

BACKGROUND: Osteosarcoma is the most common bone sarcoma in children, adolescents, and young adults. Osteosarcoma primarily arises through tumor suppressor inactivation, most typically due to TP53 attenuation mechanisms. Increasingly additional oncog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba8d653bebf2caca45545f3aaa77e521
https://doi.org/10.1158/1538-7445.am2019-3010

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Abstract 2034: LSD1 inhibition alone and in combination with chemotherapy in Ewing sarcoma cell lines

Autor: Damon R. Reed, Elliot Kahen, Darcy Welch, Christopher L. Cubitt

Publikováno v: Cancer Research. 77:2034-2034

Background: Ewing Sarcoma (ES) is the second most common primary bone cancer affecting children and young adults. Despite advances in treatment that have led to survival rates of approximately 73% for localized disease, outcomes for patients with met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bb40148256646fed7affa4a77cb4933
https://doi.org/10.1158/1538-7445.am2017-2034

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Abstract 1340: RAS pathway activation and sensitivity to therapeutic agents is correlated with NF1 residual activity in malignant peripheral nerve sheath tumors

Autor: Christopher L. Cubitt, Diana Yu, Jae K. Lee, Andrew S. Brohl, Damon R. Reed, Elliot Kahen, Darcy Welch

Publikováno v: Cancer Research. 77:1340-1340

Background: Malignant Peripheral Nerve Sheath Tumor (MPNST) is a malignant sarcoma that derives from a peripheral nerve or plexiform neurofibroma. Neurofibromatosis type 1 (NF-1) patients are particularly susceptible, with a higher risk, earlier onse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eca651905bf1304c9e76fd50010c778e
https://doi.org/10.1158/1538-7445.am2017-1340

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