Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Darcy R. Tocci"'
Autor:
Ping Bai, Prasenjit Mondal, Frederick A. Bagdasarian, Nisha Rani, Yan Liu, Ashley Gomm, Darcy R. Tocci, Se Hoon Choi, Hsiao-Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 10, Pp 3891-3904 (2022)
Although the epigenetic regulatory protein histone deacetylase 6 (HDAC6) has been recently implicated in the etiology of Alzheimer's disease (AD), little is known about the role of HDAC6 in the etiopathogenesis of AD and whether HDAC6 can be a potent
Externí odkaz:
https://doaj.org/article/fd064ae82b114df3b5e13bbc54ea4e17
Autor:
Gengyang Yuan, Darcy R. Tocci, Changning Wang, Stephen J. Haggarty, Zude Chen, Yan Liu, Hao Wang, Amelia G. Langan, Julia S. Zagaroli, Ping Bai, Robin Striar, Yu Lan, Sepideh Afshar, Debasis Patnaik
Publikováno v:
Journal of Medicinal Chemistry. 64:14745-14756
To better understand the role of bromodomain and extra-terminal domain (BET) proteins in epigenetic mechanisms, we developed a series of thienodiazepine-based derivatives and identified two compounds, 3a and 6a, as potent BET inhibitors. Further in v
Autor:
Sepideh Afshar, Amelia G. Langan, Julia S. Zagaroli, Darcy R. Tocci, Ping Bai, Changning Wang, Robin Striar, Yan Liu, Yu Lan, Hao Wang, Gengyang Yuan
Publikováno v:
Bioconjugate chemistry. 32(8)
Two tandem bromodomains (BD1 and BD2) of bromodomain and extraterminal domain (BET) family proteins have shown distinct roles in mediating gene transcription and expression. Inhibitors that interact with a specific bromodomain may contribute to a spe
Autor:
Hallie Blevins, Yiming Xu, Robin Striar, Yan Liu, Darcy R. Tocci, Gengyang Yuan, Julia S. Zagaroli, Changning Wang, Amelia G. Langan, Shijun Zhang, Yulong Xu, Yu Lan, Can Zhang
Publikováno v:
Bioorg Med Chem Lett
We report herein the discovery of a positron emission tomography (PET) tracer for the (NOD)-like receptor protein 3 (NLRP3). Our recent medicinal chemistry campaign on developing sulfonamide-based NLRP3 inhibitors led to an analog, 1, with a methoxy