Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Darcy Paige"'
Autor:
Robert S Wallis, Rodney Dawson, Sven O Friedrich, Amour Venter, Darcy Paige, Tong Zhu, Annette Silvia, Jason Gobey, Craig Ellery, Yao Zhang, Kathleen Eisenach, Paul Miller, Andreas H Diacon
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94462 (2014)
Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse models. Like linezolid, it is unaffected by mutations conferring resistance to standard TB
Externí odkaz:
https://doaj.org/article/1d2f4c6c83044d40877fbbf4225b55e9
Autor:
Robert S Wallis, Wesley Jakubiec, Mark Mitton-Fry, Lynn Ladutko, Sheldon Campbell, Darcy Paige, Annette Silvia, Paul F Miller
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30479 (2012)
There presently is no rapid method to assess the bactericidal activity of new regimens for tuberculosis. This study examined PNU-100480, TMC207, PA-824, SQ109, and pyrazinamide, singly and in various combinations, against intracellular M. tuberculosi
Externí odkaz:
https://doaj.org/article/48e699f509e54ab3b2e07f87e4b12e2d
Autor:
Tong Zhu, Annette M. Silvia, Gabriella Bedarida, Mark J. Mitton-Fry, Wesley Jakubiec, Lynn Ladutko, Paul F. Miller, Robert S. Wallis, Vikas Kumar, Darcy Paige, Sheldon Campbell
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:567-574
Tuberculosis is a serious global health threat for which new treatments are urgently needed. This study examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of the oxazolidinone PNU-100480 in healthy v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec8dc04ec5818d7ae460fb5167ba48d
https://doi.org/10.1128/aac.01179-10
https://doi.org/10.1128/aac.01179-10
Publikováno v:
Journal of Clinical Anesthesia. 9:173-178
Study Objectives: To compare, in patients who underwent major orthopedic surgical procedures, the efficacy of intravenous (IV) patient-controlled analgesia (PCA) with morphine combined with continuous administration of two doses of fentanyl or placeb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc257190178daf6241c4fb51a3aa6898
https://doi.org/10.1016/s0952-8180(97)00043-3
https://doi.org/10.1016/s0952-8180(97)00043-3
Autor:
Paul F. Miller, Robert S. Wallis, Darcy Paige, Annette M. Silvia, Dessislava Dimitrova, Vikas Kumar, Lynn Ladutko, Xiaoxi Li, Mark J. Mitton-Fry, Wesley Jakubiec, Sheldon Campbell, Gerald Friedland
Publikováno v:
The Journal of infectious diseases. 202(5)
BACKGROUND The oxazolidinone PNU-100480 is superior to linezolid against experimental murine tuberculosis. Two metabolites contribute to but do not fully account for its superiority. This study examined the safety, tolerability, pharmacokinetics, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4961a486c8b04edaa00f7707a6eada45
https://pubmed.ncbi.nlm.nih.gov/20629533
https://pubmed.ncbi.nlm.nih.gov/20629533
Publikováno v:
Canadian Journal of Anaesthesia. 39:774-779
The purpose of this randomized, double-blind study was to compare the ability of a combination of fentanyl and esmolol to blunt the haemodynamic effects of intubation with that of either agent alone. Patients received fentanyl or saline four minutes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e94ec2c4bffa6a60f9e07ffac09634f7
https://doi.org/10.1007/bf03008287
https://doi.org/10.1007/bf03008287
Autor:
Sorin J. Brull, Theresa Ning, F. B. Sevarino, David G. Silverman, Raymond S. Sinatra, Darcy Paige
Publikováno v:
Journal of Clinical Anesthesia. 4:285-288
To examine the efficacy of intramuscular (IM) ketorolac used in combination with intravenous (IV) patient-controlled analgesia (PCA) morphine for postoperative pain relief following intra-abdominal gynecologic surgery.Randomized, double-blind, placeb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e476b145ba94e06347385782fe9ee6
https://doi.org/10.1016/0952-8180(92)90130-s
https://doi.org/10.1016/0952-8180(92)90130-s
Publikováno v:
Journal of clinical anesthesia. 8(2)
Study Objective: To examine the safety and analgesic efficacy of sufentanil administered via either epidural or intravenous (IV) patient-controlled analgesia (PCA) in patients recovering from gynecologic surgery. Design: Randomized, double-blind comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f84f5f0296d3257bebb6cbd4275c656
https://pubmed.ncbi.nlm.nih.gov/8695094
https://pubmed.ncbi.nlm.nih.gov/8695094
Autor:
Annette M. Silvia, Robert S. Wallis, Darcy Paige, Sheldon Campbell, Paul F. Miller, Lynn Ladutko, Mark J. Mitton-Fry, Wesley Jakubiec
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30479 (2012)
PLoS ONE
PLoS ONE
There presently is no rapid method to assess the bactericidal activity of new regimens for tuberculosis. This study examined PNU-100480, TMC207, PA-824, SQ109, and pyrazinamide, singly and in various combinations, against intracellular M. tuberculosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c82296f0f4a6fa0c74bcb100d0e6649
https://doi.org/10.1371/journal.pone.0030479
https://doi.org/10.1371/journal.pone.0030479
Publikováno v:
Journal of clinical anesthesia. 6(1)
To determine whether intravenous (IV) doses of ketorolac tromethamine provide safe and effective augmentation of postsurgical analgesia for patients using IV patient-controlled analgesia (PCA) with morphine.Randomized, double-blind, placebo-controlle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98172ec823bd9375553591622238962b
https://pubmed.ncbi.nlm.nih.gov/8142094
https://pubmed.ncbi.nlm.nih.gov/8142094