Implementation of preemptive DNA sequence-based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

Autor: Liewei Wang, Steven E. Scherer, Suzette J. Bielinski, Donna M. Muzny, Leila A. Jones, John Logan Black, Ann M. Moyer, Jyothsna Giri, Richard R. Sharp, Eric T. Matey, Jessica A. Wright, Lance J. Oyen, Wayne T. Nicholson, Mathieu Wiepert, Terri Sullard, Timothy B. Curry, Carolyn R. Rohrer Vitek, Tammy M. McAllister, Jennifer L. St. Sauver, Pedro J. Caraballo, Konstantinos N. Lazaridis, Eric Venner, Xiang Qin, Jianhong Hu, Christie L. Kovar, Viktoriya Korchina, Kimberly Walker, HarshaVardhan Doddapaneni, Tsung-Jung Wu, Ritika Raj, Shawn Denson, Wen Liu, Gauthami Chandanavelli, Lan Zhang, Qiaoyan Wang, Divya Kalra, Mary Beth Karow, Kimberley J. Harris, Hugues Sicotte, Sandra E. Peterson, Amy E. Barthel, Brenda E. Moore, Jennifer M. Skierka, Michelle L. Kluge, Katrina E. Kotzer, Karen Kloke, Jessica M. Vander Pol, Heather Marker, Joseph A. Sutton, Adrijana Kekic, Ashley Ebenhoh, Dennis M. Bierle, Michael J. Schuh, Christopher Grilli, Sara Erickson, Audrey Umbreit, Leah Ward, Sheena Crosby, Eric A. Nelson, Sharon Levey, Michelle Elliott, Steve G. Peters, Naveen Pereira, Mark Frye, Fadi Shamoun, Matthew P. Goetz, Iftikhar J. Kullo, Robert Wermers, Jan A. Anderson, Christine M. Formea, Razan M. El Melik, John D. Zeuli, Joseph R. Herges, Carrie A. Krieger, Robert W. Hoel, Jodi L. Taraba, Scott R. St. Thomas, Imad Absah, Matthew E. Bernard, Stephanie R. Fink, Andrea Gossard, Pamela L. Grubbs, Therese M. Jacobson, Paul Takahashi, Sharon C. Zehe, Susan Buckles, Michelle Bumgardner, Colette Gallagher, Kelliann Fee-Schroeder, Nichole R. Nicholas, Melody L. Powers, Ahmed K. Ragab, Darcy M. Richardson, Anthony Stai, Jaymi Wilson, Joel E. Pacyna, Janet E. Olson, Erica J. Sutton, Annika T. Beck, Caroline Horrow, Krishna R. Kalari, Nicholas B. Larson, Hongfang Liu, Liwei Wang, Guilherme S. Lopes, Bijan J. Borah, Robert R. Freimuth, Ye Zhu, Debra J. Jacobson, Matthew A. Hathcock, Sebastian M. Armasu, Michaela E. McGree, Ruoxiang Jiang, Tyler H. Koep, Jason L. Ross, Matthew G. Hilden, Kathleen Bosse, Bronwyn Ramey, Isabelle Searcy, Eric Boerwinkle, Richard A. Gibbs, Richard M. Weinshilboum

Publikováno v: Genet Med

PURPOSE: The Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large cohort. We also generated the tools and resources necessary for clinical PGx

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d355d871839420df942f373e190f5c
https://pubmed.ncbi.nlm.nih.gov/35331649

Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin

Autor: Karl A. Nath, Timothy E. Peterson, Chen Fuh Lam, Anthony J. Croatt, Livius V. d’Uscio, Zvonimir S. Katusic, Darcy M. Richardson

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 290:H786-H793

Shear stress, imposed on the vascular endothelium by circulating blood, critically sustains vascular synthesis of nitric oxide (NO). Endothelial NO synthase (eNOS) activity is determined by heat shock protein 90 (HSP90), caveolin-1, and the cofactor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e3f28a4c795e606dda0716eceb0709
https://doi.org/10.1152/ajpheart.00759.2005

Long-Term Vitamin C Treatment Increases Vascular Tetrahydrobiopterin Levels and Nitric Oxide Synthase Activity

Autor: Livius V. d’Uscio, Zvonimir S. Katusic, Darcy M. Richardson, Sheldon Milstien, Leslie A. Smith

Publikováno v: Circulation Research. 92:88-95

In cultured endothelial cells, the antioxidant, l -ascorbic acid (vitamin C), increases nitric oxide synthase (NOS) enzyme activity via chemical stabilization of tetrahydrobiopterin. Our objective was to determine the effect of vitamin C on NOS funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6095a7fff610ac24b4e605fd1d08fa74
https://doi.org/10.1161/01.res.0000049166.33035.62

Enhanced coronary vasoconstriction to oxidative stress product, 8-epi-prostaglandinF2α, in experimental hypercholesterolemia

Autor: Patricia J.M. Best, Darcy M. Richardson, David R. Holmes, Amir Lerman, Stephanie H. Wilson, Lilach O. Lerman

Publikováno v: Cardiovascular Research. 44:601-607

The F2-isoprostanes are a family of novel prostaglandin isomers and a stable product of in vivo oxidative stress. 8-epi-prostaglandinF2 alpha, a member of this isoprostane family, is a vasoconstrictor and its local release may contribute to the abnor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9625e02db84365d9d9ec7fb912d8599
https://doi.org/10.1016/s0008-6363(99)00225-4

Attenuated In Vitro Coronary Arteriolar Vasorelaxation to Insulin-like Growth Factor I in Experimental Hypercholesterolemia

Autor: David R. Holmes, Darcy M. Richardson, Amir Lerman, Pinchas Cohen, David Hasdai, Robert A. Rizza, Michael F. Nielsen

Publikováno v: Hypertension. 34:89-95

Abstract —Insulin and insulin-like growth factor (IGF) 1 affect coronary vasoactivity. Experimental hypercholesterolemia is associated with coronary atherogenesis and altered vasomotor regulation. Because the IGF axis is altered during atherogenesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb488d01c35553ac107bce6d66cdd47
https://doi.org/10.1161/01.hyp.34.1.89