Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Darcy Lidington"'
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105058- (2024)
Summary: Background: In male mice, a circadian rhythm in myogenic reactivity influences the extent of brain injury following subarachnoid haemorrhage (SAH). We hypothesized that female mice have a different cerebrovascular phenotype and consequently,
Externí odkaz:
https://doaj.org/article/4d21735df72044e581d07871698243fa
Autor:
Lotte Vanherle, Darcy Lidington, Franziska E. Uhl, Saskia Steiner, Stefania Vassallo, Cecilia Skoug, Joao M.N. Duarte, Sangeetha Ramu, Lena Uller, Jean-François Desjardins, Kim A. Connelly, Steffen-Sebastian Bolz, Anja Meissner
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104384- (2022)
Summary: Background: Cognitive impairment is a serious comorbidity in heart failure patients, but effective therapies are lacking. We investigated the mechanisms that alter hippocampal neurons following myocardial infarction (MI). Methods: MI was ind
Externí odkaz:
https://doaj.org/article/e8c849e59b7542508bc162f64d7699da
Autor:
Darcy Lidington, PhD, Jessica C. Fares, MSc, Franziska E. Uhl, PhD, Danny D. Dinh, MSc, Jeffrey T. Kroetsch, PhD, Meghan Sauvé, PhD, Firhan A. Malik, PhD, Frank Matthes, PhD, Lotte Vanherle, MSc, Arman Adel, BSc, Abdul Momen, MD, PhD, Hangjun Zhang, MD, Roozbeh Aschar-Sobbi, PhD, Warren D. Foltz, PhD, Hoyee Wan, BSc, Manabu Sumiyoshi, MD, R. Loch Macdonald, MD, PhD, Mansoor Husain, MD, Peter H. Backx, PhD, DVM, Scott P. Heximer, PhD, Anja Meissner, PhD, Steffen-Sebastian Bolz, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 940-958 (2019)
Summary: Heart failure (HF) and subarachnoid hemorrhage (SAH) chronically reduce cerebral perfusion, which negatively affects clinical outcome. This work demonstrates a strong relationship between cerebral artery cystic fibrosis transmembrane conduct
Externí odkaz:
https://doaj.org/article/aa194954f9a94652a93d9a32f78df8cb
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Subarachnoid hemorrhage (SAH) is a devastating stroke subtype with a high rate of mortality and morbidity. The poor clinical outcome can be attributed to the biphasic course of the disease: even if the patient survives the initial bleeding emergency,
Externí odkaz:
https://doaj.org/article/b67a2b9dedd541ffb056596170d9fd8d
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Several pathological manifestations in coronavirus disease 2019 (COVID-19), including thick mucus, poor mucociliary clearance, and bronchial wall thickening, overlap with cystic fibrosis disease patterns and may be indicative of “acquired” cystic
Externí odkaz:
https://doaj.org/article/e851c039bbca4fe79ed839b7fd3fa579
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its clinical manifestation (COVID-19; coronavirus disease 2019) have caused a worldwide health crisis. Disruption of epithelial and endothelial barriers is a key clinical turning po
Externí odkaz:
https://doaj.org/article/149efd5e12a3428da01e848bc143b84f
Autor:
Danny D. Dinh, Darcy Lidington, Jeffrey T. Kroetsch, Chloe Ng, Hangjun Zhang, Sergei A. Nedospasov, Scott P. Heximer, Steffen-Sebastian Bolz
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Subarachnoid hemorrhage (SAH) is a devastating cerebral event caused by an aneurysmal rupture. In addition to neurological injury, SAH has significant effects on cardiac function and the peripheral microcirculation. Since these peripheral complicatio
Externí odkaz:
https://doaj.org/article/7543153341d748edb58e8deb49abf7d5
Autor:
Jeffrey T. Kroetsch, Andrew S. Levy, Hangjun Zhang, Roozbeh Aschar-Sobbi, Darcy Lidington, Stefan Offermanns, Sergei A. Nedospasov, Peter H. Backx, Scott P. Heximer, Steffen-Sebastian Bolz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
TNF is typically viewed as an inflammatory mediator. Here the authors identify a non-inflammatory mechanism conserved across species whereby the constitutively expressed smooth muscle cell TNF mediates myogenic signal transduction in skeletal muscle
Externí odkaz:
https://doaj.org/article/cfecfa36235d47528943452ab436b052
Autor:
Firhan A Malik, Anja Meissner, Illya Semenkov, Steven Molinski, Stan Pasyk, Saumel Ahmadi, Hai H Bui, Christine E Bear, Darcy Lidington, Steffen-Sebastian Bolz
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130313 (2015)
The cystic fibrosis transmembrane conductance regulator (CFTR) attenuates sphingosine-1-phosphate (S1P) signaling in resistance arteries and has emerged as a prominent regulator of myogenic vasoconstriction. This investigation demonstrates that S1P i
Externí odkaz:
https://doaj.org/article/50f1f3716a3742b2861b9a3681b6dde8
Autor:
Sonya Hui, Andrew S Levy, Daniel L Slack, Marcus J Burnstein, Lee Errett, Daniel Bonneau, David Latter, Ori D Rotstein, Steffen-Sebastian Bolz, Darcy Lidington, Julia Voigtlaender-Bolz
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138142 (2015)
We recently identified sphingosine-1-phosphate (S1P) signaling and the cystic fibrosis transmembrane conductance regulator (CFTR) as prominent regulators of myogenic responsiveness in rodent resistance arteries. However, since rodent models frequentl
Externí odkaz:
https://doaj.org/article/0076cb92bd094f78ae1922ad9df7ac14