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Data from Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast Cancer

Autor: Todd W. Miller, Alan R. Eastman, Jonathan D. Marotti, Lionel D. Lewis, Darcy Bates, Eugene Demidenko, Michelle A. Nannini, Xiaolin Zhang, Jodie Pang, Laurent Salphati, Jennifer R. Bean, Stephanie C. Liu, Kevin Shee, Lloye M. Dillon, Sarah R. Hosford, Wei Yang

Purpose: Phosphatidylinositol 3-kinase (PI3K) inhibitors are being developed for the treatment of estrogen receptor α (ER)–positive breast cancer in combination with antiestrogens. Understanding the temporal response and pharmacodynamic effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f086589c547a57eaef4c868b65fbd0
https://doi.org/10.1158/1078-0432.c.6523695.v1

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Supplementary data from Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast Cancer

Supplementary Methods; Table. S1- Pairwise comparisons of tumor growth patterns between treatment groups; Fig. S1- PI3K inhibition induces ER activation; Fig. S2- Transient, complete inhibition of PI3K more effectively suppresses cell growth than chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1174760ad75a4c2c93728ad98c4c0b61
https://doi.org/10.1158/1078-0432.22457787.v1

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Kynurenine‐Induced Aryl Hydrocarbon Receptor Signaling in Mice Causes Body Mass Gain, Liver Steatosis, and Hyperglycemia

Autor: Itzel Y. Rojas, Mary D. Chamberlin, Craig R. Tomlinson, Owen M. Wilkins, Benjamin J. Moyer, Lionel D. Lewis, Darcy Bates Pooler, Carol S. Ringelberg, Tor D. Tosteson, Dylan B Ness, Shodeinde A. Coker

Publikováno v: Obesity. 29:337-349

Objective The aryl hydrocarbon receptor (AHR) plays a key role in obesity. In vitro studies revealed that the tryptophan metabolite kynurenine (Kyn) activates AHR signaling in cultured hepatocytes. The objective of this study was to determine whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ead03d2908f8759b671440688e8ec0
https://doi.org/10.1002/oby.23065

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An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma

Autor: Lionel D. Lewis, William B. Kinlaw, Evan M Dunkley, Leslie E. Lupien, Darcy Bates Pooler, Maxwell Gabriel Foisey, Margaret J Maloy, Paul W. Baures, Ian B Lehner, Maddison E Ouellette

Publikováno v: J Pharmacol Exp Ther

It is well recognized that many cancers are addicted to a constant supply of fatty acids (FAs) and exhibit brisk de novo FA synthesis. Upregulation of a key lipogenic enzyme, fatty acid synthase (FASN), is a near-universal feature of human cancers an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82d382611c1c51dfe8934b311f6e5de
https://doi.org/10.1124/jpet.119.258947

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B-Cell Receptor Signaling Suppresses TAp63-Induced Apoptosis Via PI3-K/mTOR Pathway and Upregulation of MiR-21 in Chronic Lymphocytic Leukemia (CLL)

Autor: Darcy Bates, Prabhjot Kaur, Alexey V. Danilov, Claire Godbersen, Leigh Ann Humphries

Publikováno v: Blood. 120:562-562

Abstract 562 p63, an ancestral homolog of p53, encodes two major variants that have variable expression and context-specific functions in malignant tissues. We and others have shown that N-terminally truncated ΔNp63 promotes tumor growth in carcinom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::637e583b58697393a230be7760aac9b3
https://doi.org/10.1182/blood.v120.21.562.562

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