Zobrazeno 1 - 10 of 107 pro vyhledávání: '"Darcy B. Wilson"'
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Immunogenically optimized peptides derived from natural mutants of HIV CTL epitopes and peptide combinatorial libraries
Autor: Darcy B. Wilson, Keiko Osawa, Sylvie E. Blondelle, Rosa Moya-Castro, Kim Schroder
Publikováno v: Biopolymers. 90:683-694
Two strategies were aimed at identifying immunogenically optimized peptides for the potential use in the formulation of an effective prophylactic or therapeutic HIV-1 vaccine. Three CTL epitopes were investigated: Gag p24(19-27) TV9, Gag p17(77-85) S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db32455ae86a30fc61fb41954f2b9d26
https://doi.org/10.1002/bip.21020
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3
The cytotoxic T cell response to peptide analogs of the HLA-A*0201-restricted MUC1 signal sequence epitope, M1.2
Autor: Teri A. Lund, Elyse Paul, Andrew K. Sewell, Darcy B. Wilson, June Kan-Mitchell, Kim Schroder, Malcolm S. Mitchell, Francesco M. Marincola
Publikováno v: Cancer Immunology, Immunotherapy. 56:287-301
The mucin MUC1 molecule is overexpressed on a variety of adenocarcinomas and is thus, a potential target for immunotherapy. Of the MUC1 peptides that bind to HLA-A*0201(A2), M1.2 (LLLLTVLTV) from the signal sequence appears to be the most immunogenic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a68463cc50b035dec07d978852344b
https://doi.org/10.1007/s00262-006-0191-1
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4
Degeneracy and Repertoire of the Human HIV-1 Gag p1777–85 CTL Response
Autor: Jason M. Brenchley, June Kan-Mitchell, Hwee L. Ng, Dianne H. Wilson, Brygida Bisikirska, Keri L. Schaubert, David Price, Judith Abrams, Otto O. Yang, Daniel C. Douek, Sylvie E. Blondelle, Darcy B. Wilson, Melissa Bajcz, Cesar Boggiano, José Miguel Benito, Ramakrishna Hegde, F. M. Marincola, Tedi E. Asher, Charles R. Rinaldo
Publikováno v: The Journal of Immunology. 176:6690-6701
CD8+ CTL responses are important for the control of HIV-1 infection. The immunodominant HLA-A2-restricted Gag epitope, SLYNTVATL (SL9), is considered to be a poor immunogen because reactivity to it is rare in acute infection despite its paradoxical d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8653b3cc13dbdd530ecae2307815fa
https://doi.org/10.4049/jimmunol.176.11.6690
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5
A Peptide of Glutamic Acid Decarboxylase 65 Can Recruit and Expand a Diabetogenic T Cell Clone, BDC2.5, in the Pancreas
Autor: Eli E. Sercarz, Darcy B. Wilson, Emma L. Masteller, Agnès Lehuen, Kent P. Jensen, Yang D. Dai, Jeffrey A. Bluestone
Publikováno v: The Journal of Immunology. 175:3621-3627
Self peptide-MHC ligands create and maintain the mature T cell repertoire by positive selection in the thymus and by homeostatic proliferation in the periphery. A low affinity/avidity interaction among T cells, self peptides, and MHC molecules has be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efac2d9fabb7417541bc3eb40778501
https://doi.org/10.4049/jimmunol.175.6.3621
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6
Antigenicity and immunogenicity of peptide analogues of a low affinity peptide of the human telomerase reverse transcriptase tumor antigen
Autor: Maurizio Zanetti, Sylvie E. Blondelle, April Simora, Darcy B. Wilson, Kim Schoeder, Yu Chun Lone, Fancisco Garcia Pons, Pierre Langlade-Demoyen, Javier Hernández
Publikováno v: European Journal of Immunology. 34:2331-2341
Human telomerase reverse transcriptase (hTRT) is a potential target for therapeutic vaccination against cancer. Therefore, it is critically important to identify T cell epitopes useful to induce cytotoxic T cell responses. Here we used a positional s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67c09a364441ab0be1f1caf328eb264
https://doi.org/10.1002/eji.200425134
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7
Specificity and degeneracy of T cells
Autor: Kim Schroder, Darcy B. Wilson, K. Christopher Garcia, Richard A. Houghten, Dianne H. Wilson, Clemencia Pinilla, Sylvie E. Blondelle
Publikováno v: Molecular Immunology. 40:1047-1055
The extent of T cell cross-reactivity is significant, even to the point where the terms "promiscuous" and "degenerate" apply. Degeneracy is an important feature of the immune response mechanism that permits effective T cell responses to a vast number
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e269d9ee88fa3ad80ce8c26f83527f
https://doi.org/10.1016/j.molimm.2003.11.022
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8
Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation
Autor: Dar Chone Chow, Nelida Prado, Erin J. Adams, Xiaolin He, Michelle Krogsgaard, Mark M. Davis, Darcy B. Wilson, K. Christopher Garcia
Publikováno v: Molecular Cell. 12:1367-1378
While in many cases the half-life of T cell receptor (TCR) binding to a particular ligand is a good predictor of activation potential, numerous exceptions suggest that other physical parameter(s) must also play a role. Accordingly, we analyzed the th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9638d7ce2f1fa580086a12f31cd16f4
https://doi.org/10.1016/s1097-2765(03)00474-x
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10
Drug discovery and vaccine development using mixture-based synthetic combinatorial libraries
Autor: Darcy B. Wilson, Clemencia Pinilla, Richard A. Houghten
Publikováno v: Drug Discovery Today. 5:276-285
The approaches and concepts that encompass combinatorial chemistry represent a paradigm shift in drug discovery and basic research. Viewed initially as a curiosity by the pharmaceutical industry, combinatorial chemistry approaches are now recognized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37fc78b5e336bbbc0a81a0f3fcfe28b
https://doi.org/10.1016/s1359-6446(00)01513-0
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