Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Darcie J. Miller"'
Autor:
Efren Garcia-Maldonado, Andrew D. Huber, Sergio C. Chai, Stanley Nithianantham, Yongtao Li, Jing Wu, Shyaron Poudel, Darcie J. Miller, Jayaraman Seetharaman, Taosheng Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Nuclear receptors are ligand-activated transcription factors that can often be useful drug targets. Unfortunately, ligand promiscuity leads to two-thirds of receptors remaining clinically untargeted. PXR is a nuclear receptor that can be act
Externí odkaz:
https://doaj.org/article/c30e189d2e734c8aad1bc9b3e758e589
Autor:
Gisele Nishiguchi, Lauren G. Mascibroda, Sarah M. Young, Elizabeth A. Caine, Sherif Abdelhamed, Jeffrey J. Kooijman, Darcie J. Miller, Sourav Das, Kevin McGowan, Anand Mayasundari, Zhe Shi, Juan M. Barajas, Ryan Hiltenbrand, Anup Aggarwal, Yunchao Chang, Vibhor Mishra, Shilpa Narina, Melvin Thomas, Allister J. Loughran, Ravi Kalathur, Kaiwen Yu, Suiping Zhou, Xusheng Wang, Anthony A. High, Junmin Peng, Shondra M. Pruett-Miller, Danette L. Daniels, Marjeta Urh, Anang A. Shelat, Charles G. Mullighan, Kristin M. Riching, Guido J. R. Zaman, Marcus Fischer, Jeffery M. Klco, Zoran Rankovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Molecular-glue degraders are small molecules that induce a specific interaction between an E3 ligase and a target protein, resulting in the target proteolysis. The discovery of molecular glue degraders currently relies mostly on screening ap
Externí odkaz:
https://doaj.org/article/93a742dfa7284effac1e877a18d0d84e
Autor:
Seung Wook Yang, Xin Huang, Wenwei Lin, Jaeki Min, Darcie J. Miller, Anand Mayasundari, Patrick Rodrigues, Elizabeth C. Griffith, Clifford T. Gee, Lei Li, Wei Li, Richard E. Lee, Zoran Rankovic, Taosheng Chen, Patrick Ryan Potts
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Testis-restricted melanoma antigen (MAGE) proteins function as substrate adapters for E3 ubiquitin ligases. Biochemical and structural analyses of MAGE-A11 provide insight into the substrate binding mode of MAGE proteins and enable discovery of poten
Externí odkaz:
https://doaj.org/article/b277e39e14d144a186f5155bc60329ef
Autor:
Andrew D. Huber, Wenwei Lin, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Autor:
Wenwei Lin, Andrew D. Huber, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Ligand-binding promiscuity in detoxification systems protects the body from toxicological harm but is a roadblock to drug development due to the difficulty in optimizing small molecules to both retain target potency and avoid metabolic events. Immens
Publikováno v:
The Journal of biological chemistry. 298(8)
Sulfonolipids are unusual lipids found in the outer membranes of Gram-negative bacteria in the phylum Bacteroidetes. Sulfonolipid and its deacylated derivative, capnine, are sulfur analogs of ceramide-1-phosphate and sphingosine-1-phosphate, respecti
Autor:
Elizabeth C. Griffith, Anand Mayasundari, Darcie J. Miller, Patrick Rodrigues, Zoran Rankovic, Jaeki Min, Patrick Ryan Potts, Clifford T. Gee, Richard E. Lee, Seung Wook Yang, Xin Huang, Wenwei Lin, Taosheng Chen, Lei Li, Wei Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Testis-restricted melanoma antigen (MAGE) proteins are frequently hijacked in cancer and play a critical role in tumorigenesis. MAGEs assemble with E3 ubiquitin ligases and function as substrate adaptors that direct the ubiquitination of novel target
Publikováno v:
J Mol Biol
Imatinib is an ATP-competitive inhibitor of Bcr-Abl kinase and the first drug approved for chronic myelogenous leukemia (CML) treatment. Here we show that imatinib binds to a secondary, allosteric site located in the myristoyl pocket of Abl to functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f889221c982e501df73696024f00b03
https://europepmc.org/articles/PMC8752476/
https://europepmc.org/articles/PMC8752476/
Autor:
Siquan Chen, Asif Zubair, Ravi C. Kalathur, M. Madan Babu, Jon P. Connelly, Darcie J. Miller, Kaley Blankenship, Min Pan, Michael A. Dyer, Jake E. Batchelder, Shondra M. Pruett-Miller, Brandt C. Huddle, Matthew J. Posgai, Scott C. Blanchard, William C. Wright, Richard H. Chapple, Samuel W. Brady, Sivaraman Natarajan, Payton Archer, John Easton, Elizabeth Stewart, Paul Geeleher, Jonathan Low, Lucy A. Godley, John D. Schuetz, Taosheng Chen, Manbir Sandhu, Burgess B. Freeman, Yingzhe Wang, Brittney Gordon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
Survival in high-risk pediatric neuroblastoma has remained around 50% for the last 20 years, with immunotherapies and targeted therapies having had minimal impact. Here, we identify the small molecule CX-5461 as selectively cytotoxic to high-risk neu
Autor:
Darcie J. Miller, Vivian Stojanoff, Maham Ismail, Aditya Seetharaman, Priyadharshine Ramesh Babu
Ferritin is an ubiquitous iron storage protein found in all kingdoms of life. Ferritin is essential for iron homeostasis and is involved in a wide range of physiological and pathological processes. Several structures of ferr itin in complex with smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c4c921d320db79684aafd524633dc2
https://doi.org/10.1101/2021.09.30.462655
https://doi.org/10.1101/2021.09.30.462655