Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Darci J. Phillips"'
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Multiple myeloma (MM) is a plasma cell malignancy and the second most common hematological neoplasm in adults, comprising 1.8% of all cancers. With an annual incidence of ~30,770 cases in the United States, MM has a high mortality rate, leading to 12
Externí odkaz:
https://doaj.org/article/7faed8b81ba349cbac18f6cbdb28cacf
Autor:
Magdalena Matusiak, John W. Hickey, Bogdan Luca, Guolan Lu, Lukasz Kidzinski, Shirley Shu, Deana Rae Crystal Colburg, Darci J. Phillips, Sky W. Brubaker, Gregory W. Charville, Jeanne Shen, Garry P. Nolan, Aaron M. Newman, Robert B. West, Matt van de Rijn
SummaryMacrophages are the most abundant immune cell type in the tumor microenvironment (TME). Yet the spatial distribution and cell interactions that shape macrophage function are incompletely understood. Here we use single-cell RNA sequencing data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa4a4ae8c952c8e49bcb89dbd8efe3c6
https://doi.org/10.1101/2022.08.18.504434
https://doi.org/10.1101/2022.08.18.504434
Autor:
Garry P. Nolan, Julia Kennedy-Darling, Vishal G. Venkataraaman, John W. Hickey, Darci J. Phillips, Nikolay Samusik, Yury Goltsev, Sarah Black, Christian M. Schürch
Publikováno v:
Nat Protoc
Advances in multiplexed imaging technologies have drastically improved our ability to characterize healthy and diseased tissues at the single-cell level. Co-detection by indexing (CODEX) relies on DNA-conjugated antibodies and the cyclic addition and
Autor:
Jennifer Y. Wang, Jinah Kim, Mika M. Tabata, Wen-Kai Weng, Silvina Pugliese, Bernice Y. Kwong, Darci J. Phillips
Publikováno v:
Clinical Case Reports, Vol 7, Iss 12, Pp 2491-2494 (2019)
Clinical Case Reports
Clinical Case Reports
Chronic cutaneous graft‐vs‐host disease (GVHD) has several atypical variants. We describe two cases of GVHD with clinical and histopathologic features of pityriasis rubra pilaris (PRP), which responded to additional immunosuppression. Recognition
Autor:
Kimberly S. Smythe, Darci J. Phillips, Robert H. Pierce, Salil S. Bhate, Yury Goltsev, Youn H. Kim, Magdalena Matusiak, Christian M. Schürch, Steven P. Fling, Garry P. Nolan, Martin A. Cheever, Janos Demeter, Graham L. Barlow, Sizun Jiang, Nirasha Ramchurren, Robert West, Michael S. Khodadoust, Belén Rivero Gutierrez
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Cutaneous T cell lymphomas (CTCL) are rare but aggressive cancers without effective treatments. While a subset of patients derive benefit from PD-1 blockade, there is a critically unmet need for predictive biomarkers of response. Herein, we perform C
Autor:
Candace Liu, Bokai Zhu, David R. McIlwain, Han Chen, Graham L. Barlow, Yunhao Bai, Noah F. Greenwald, Garry P. Nolan, Kathleen Busman-Sahay, Margaret Terry, Xavier Rovira-Clavé, Skyler Younger, Jason L. Weirather, Nilanjan Mukherjee, Michael Angelo, Sizun Jiang, Chi Ngai Chan, Darci J. Phillips, Jacob D. Estes, John-Paul Oliveria, Marc Bosse, Michael Nekorchuk, Janos Demeter, Yury Golstev, Erin McCaffrey
Publikováno v:
SSRN Electronic Journal.
A thorough understanding of complex spatial host-disease interactions in situ is necessary in order to develop effective preventative measures and therapeutic strategies. Here, we developed Protein And Nucleic acid IN situ Imaging (PANINI) and couple
Autor:
Garry P. Nolan, Robert B. West, Youn H. Kim, Christian M. Schürch, Darci J. Phillips, Salil S. Bhate, B Rivero Gutierrez, Magdalena Matusiak, Khodadoust, Graham L. Barlow
Publikováno v:
On Demand Talks.
Background Immunotherapies have induced long-lasting remissions in countless advanced-stage cancer patients, but many more patients have not benefitted. Therefore, novel predictive markers are needed to stratify patients before treatment and select t
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Multiple myeloma (MM) is a plasma cell malignancy and the second most common hematological neoplasm in adults, comprising 1.8% of all cancers. With an annual incidence of ~30,770 cases in the United States, MM has a high mortality rate, leading to 12
Autor:
Sarah Black, Christian M. Schürch, Darci J. Phillips, Yury Goltsev, Janos Demeter, Garry P. Nolan, Nikolay Samusik, Inti Zlobec, Graham L. Barlow, Pauline Chu, Luca Noti, Salil S. Bhate, David R. McIlwain, Shigemi Kinoshita
Publikováno v:
Cell
Schürch, Christian M; Bhate, Salil S; Barlow, Graham L; Phillips, Darci J; Noti, Luca; Zlobec, Inti; Chu, Pauline; Black, Sarah; Demeter, Janos; McIlwain, David R; Kinoshita, Shigemi; Samusik, Nikolay; Goltsev, Yury; Nolan, Garry P (2020). Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front. Cell, 182(5), 1341-1359.e19. Cell Press 10.1016/j.cell.2020.07.005
Schürch, Christian M; Bhate, Salil S; Barlow, Graham L; Phillips, Darci J; Noti, Luca; Zlobec, Inti; Chu, Pauline; Black, Sarah; Demeter, Janos; McIlwain, David R; Kinoshita, Shigemi; Samusik, Nikolay; Goltsev, Yury; Nolan, Garry P (2020). Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front. Cell, 183(3), p. 838. Cell Press 10.1016/j.cell.2020.10.021
Schürch, Christian M; Bhate, Salil S; Barlow, Graham L; Phillips, Darci J; Noti, Luca; Zlobec, Inti; Chu, Pauline; Black, Sarah; Demeter, Janos; McIlwain, David R; Kinoshita, Shigemi; Samusik, Nikolay; Goltsev, Yury; Nolan, Garry P (2020). Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front. Cell, 182(5), 1341-1359.e19. Cell Press 10.1016/j.cell.2020.07.005
Schürch, Christian M; Bhate, Salil S; Barlow, Graham L; Phillips, Darci J; Noti, Luca; Zlobec, Inti; Chu, Pauline; Black, Sarah; Demeter, Janos; McIlwain, David R; Kinoshita, Shigemi; Samusik, Nikolay; Goltsev, Yury; Nolan, Garry P (2020). Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front. Cell, 183(3), p. 838. Cell Press 10.1016/j.cell.2020.10.021
Summary Antitumoral immunity requires organized, spatially nuanced interactions between components of the immune tumor microenvironment (iTME). Understanding this coordinated behavior in effective versus ineffective tumor control will advance immunot
Autor:
Darci J. Phillips, Steven P. Fling, Robert H. Pierce, Robert B. West, Belén Rivero Gutierrez, Christian M. Schürch, Magdalena Matusiak, Graham L. Barlow, Martin A. Cheever, Youn H. Kim, Salil S. Bhate, Michael S. Khodadoust, Nirasha Ramchurren, Garry P. Nolan
Publikováno v:
Cancer Research. 80:6669-6669
Cutaneous T-cell lymphoma (CTCL) is a rare, incurable CD4+ T cell malignancy of the skin with a 5-year survival rate of less than 30% in advanced stages. Immune checkpoint inhibitors, such as anti-PD-1 antibodies, have shown dramatic clinical efficac