Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Darby Schmidt"'
Autor:
Francesco Marincola, Yeon Sook Choi, Aesha Upadhyay, Maria Cristina Munteanu, Taronish Dubash, Cristian Nunez, Shrouq Farah, Gabriel Brown, Branko Radetich, Darby Schmidt, Nadia Gurvich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/b77f9fb7459948dfb526c7a03f19205b
Autor:
Ashraf Wilsily, Robert Zahler, Nan Ke, Claudio Chuaqui, Michael J. Bradley, Jason J. Marineau, Goran Malojčić, Stephane Ciblat, Anneli Savinainen, Darby Schmidt, Nigel J. Waters, Kristin B. Hamman, Sydney Alnemy, Stephanie Roy, Dana K. Winter, Anzhelika Kabro, Kenneth Matthew Whitmore, Shanhu Hu, Janessa Mihalich
Publikováno v:
Journal of medicinal chemistry. 65(2)
CDK7 has emerged as an exciting target in oncology due to its roles in two important processes that are misregulated in cancer cells: cell cycle and transcription. This report describes the discovery of SY-5609, a highly potent (sub-nM CDK7 Kd) and s
Autor:
Nan Ke, Yoon Jong Choi, David A. Orlando, Emmanuelle di Tomaso, Kevin Sprott, Christian Fritz, Shanhu Hu, Michael J. Bradley, John Carulli, Darby Schmidt, Eric R. Olson, Stephane Ciblat, Nisha Rajagopal, Jason J. Marineau, J. Graeme Hodgson, Dana K. Winter, Anzhelika Kabro, Yixuan Ren, Kristin B. Hamman, Sydney Alnemy, Liv Johannessen
Publikováno v:
Cancer Research. 79:3479-3491
Recent studies suggest that targeting transcriptional machinery can lead to potent and selective anticancer effects in cancers dependent on high and constant expression of certain transcription factors for growth and survival. Cyclin-dependent kinase
Autor:
Chris M. Thompson, Darby Schmidt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127462
This review covers case studies in rare disease small molecule drug discovery with an emphasis on the use of new technologies and innovative target approaches. Case studies include examples of covalent modification, inducement of alternative splicing
Autor:
Lisa A. Orband-Miller, Erkan Baloglu, Jianfei Yang, Ashley A. Barnes, Jill Skepner, Thaddeus J. Carlson, Darby Schmidt, Mark S. Sundrud, Shomir Ghosh, Mercedes Lobera, Jonathan Hill, Radha Ramesh, Mohamed Boudjelal, Mark Trocha
Publikováno v:
The Journal of Immunology. 192:2564-2575
IL-17–producing CD4+Th17 cells, CD8+Tc17 cells, and γδ T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORγt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel
Autor:
Tom G. Holt, Michael Wolff, Peggy E. McCann, Silvi Lubell, M. Gerard Waters, Andrew K.P. Taggart, Mihajlo L. Krsmanovic, Abigail Lee Smenton, Steven L. Colletti, Daniel Blom, James R. Tata, Darby Schmidt, Subharekha Raghavan, Ning Ren, Tanya Ciecko, Kang Cheng, Ester Carballo-Jane, Larissa Wilsie
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4768-4772
Niacin is an effective drug for raising HDL cholesterol and reducing coronary risks, but patients show low compliance with treatment due to severe facial flushing upon taking the drug. A series of bicyclic pyrazole carboxylic acids were synthesized a
Autor:
Andrew K.P. Taggart, Abby Smenton, Steven L. Colletti, Scott Tria, Subharekha Raghavan, Sookhee Chang, M. Gerard Waters, Darby Schmidt, James R. Tata, Thomas O. Schrader, Rui Liang, Jae-Kyu Jung, Craig K. Esser, Jason E. Imbriglio, Kang Cheng, Ester Carballo-Jane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2121-2124
5-Alkyl and aryl-pyrazole–tetrazoles have been identified as a new class of selective, small-molecule, agonists of the human G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.
Publikováno v:
Journal of Combinatorial Chemistry. 6:286-292
In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists
Autor:
Jill Skepner, Erkan Baloglu, Jonathan Hill, Mark Trocha, Mark S. Sundrud, Xiaoyan Qu, Michael A. Nolan, Radha Ramesh, Jianfei Yang, Scott Davis, Shomir Ghosh, Thaddeus J. Carlson, Darby Schmidt, Mercedes Lobera
Publikováno v:
Immunology. 145(3)
The orphan nuclear receptor, retinoic acid receptor-related orphan nuclear receptor γt (RORγt), is required for the development and pathogenic function of interleukin-17A-secreting CD4(+) T helper type 17 (Th17) cells. Whereas small molecule RORγt
Autor:
Peter B. Rahl, Jinsong Wang, Yonghui Wang, Chuan Wu, Xichen Lin, Mark S. Sundrud, Sheng Xiao, Mercedes Lobera, Zhong Zhong, Jianfei Yang, Alexander Marson, Karsten Kretschmer, Yan Xu, Pei-Yun Tsai, Aviv Regev, Radha Ramesh, Erkan Baloglu, Shomir Ghosh, David A. Hafler, Chen Zhu, Zhijun Xiang, Richard A. Young, Ling Zhou, Vijay K. Kuchroo, Darby Schmidt, Nir Yosef
Publikováno v:
Immunity, vol 40, iss 4
PMC
PMC
We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including Th17-cell-mediated autoimmune disease. We systemically characterized RORγt binding in the presence a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62b927ac7d62181e49ec164d7ead0e1
https://europepmc.org/articles/PMC4066874/
https://europepmc.org/articles/PMC4066874/