ERBB4 Mutant Alleles May Drive BRAF WT Melanomas

Autor: Lauren M. Lucas, Richard L. Cullum, Jessica A. Markham, Joelle N. Woggerman, Vipasha Dwivedi, Rania H. Mohamedelhassan, Laura J. Cook, Connor M. Kelley, Elizabeth L. Knerr, David P. Kaufmann, Megan A. Jacobi, Darby C. Taylor, Cristina C. Rael, Damien S. Waits, Taraswi M. Ghosh, Kenneth M. Halanych, Ram B. Gupta, David J. Riese

Metastatic skin cutaneous melanomas that contain wild-type BRAF alleles (“BRAF WT melanomas”) remain a significant clinical challenge, primarily because of the paucity of targets for therapeutic intervention. In prior work, in silico analyses of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56774191e9e618b913c9fdf142257902
https://doi.org/10.1101/2022.06.21.22276707

Abstract A19: Discovery and characterization of selective and nonselective inhibitors of ErbB4 signaling: Putative targeted melanoma therapeutics

Autor: Mackenzie H. Harris, Laura J. Cook, Ram B. Gupta, David J. Riese, Allan E. David, John T. Piazza, Darby C. Taylor, Richard L. Cullum, David Z. Kaufmann, Cristina C. Rael, Logan Neel, Lauren M. Lucas, Jared I. Senfeld

Publikováno v: Cancer Research. 80:A19-A19

Introduction: Gain-of-function mutations in the gene that encodes the ErbB4 receptor tyrosine kinase have been found in a significant fraction of melanoma samples. Melanoma cell lines that harbor some of these mutations are dependent on ErbB4 for pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08654f96538007851a62489eba1d7884
https://doi.org/10.1158/1538-7445.mel2019-a19

Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics.

Autor: Cullum, Richard L.^1,2 (AUTHOR), Lucas, Lauren M.¹ (AUTHOR), Senfeld, Jared I.¹ (AUTHOR), Piazza, John T.^1,3 (AUTHOR), Neel, Logan T.¹ (AUTHOR), Whig, Kanupriya⁴ (AUTHOR), Zhai, Ling⁴ (AUTHOR), Harris, Mackenzie H.^1,2 (AUTHOR), Rael, Cristina C.^1,3 (AUTHOR), Taylor, Darby C.^1,3 (AUTHOR), Cook, Laura J.^1,5 (AUTHOR), Kaufmann, David P.¹ (AUTHOR), Mill, Christopher P.^1,6 (AUTHOR), Jacobi, Megan A.¹ (AUTHOR), Smith, Forrest T.¹ (AUTHOR), Suto, Mark⁴ (AUTHOR), Bostwick, Robert⁴ (AUTHOR), Gupta, Ram B.^2,7 (AUTHOR), David, Allan E.² (AUTHOR), Riese, II, David J.¹ (AUTHOR) djr0009@auburn.edu

Publikováno v: PLoS ONE. 12/30/2020, Vol. 15 Issue 12, p1-23. 23p.

Review article: the pathogenesis of diverticular disease - current perspectives on motility and neurotransmitters.

Autor: Jeyarajah, S.¹ (AUTHOR), Papagrigoriadis, S.¹ (AUTHOR)

Publikováno v: Alimentary Pharmacology & Therapeutics. Apr2011, Vol. 33 Issue 7, p789-800. 12p. 1 Diagram, 3 Charts.

Facile Nanolization Strategy for Therapeutic Ganoderma Lucidum Spore Oil to Achieve Enhanced Protection against Radiation-Induced Heart Disease.

Autor: Dai C; The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, 510632, China., He L; The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, 510632, China., Ma B; The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, 510632, China., Chen T; The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, 510632, China.

Publikováno v: Small (Weinheim an der Bergstrasse, Germany) [Small] 2019 Sep; Vol. 15 (36), pp. e1902642. Date of Electronic Publication: 2019 Jul 28.