Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Darakhshanda Shehnaz"'
Autor:
Hartmut Grasemann, Darakhshanda Shehnaz, Masahiro Enomoto, Michael Leadley, Jaques Belik, Felix Ratjen
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46618 (2012)
Increased arginase activity contributes to airway nitric oxide (NO) deficiency in cystic fibrosis (CF). Whether down-stream products of arginase activity contribute to CF lung disease is currently unknown. The objective of this study was to test whet
Externí odkaz:
https://doaj.org/article/3b99ae414ef14f90815ebde292b7d81c
Autor:
Jaques Belik, Suhail Al-Saleh, Jeremy A. Scott, Reshma Amin, Hartmut Grasemann, Mahroukh Rafii, Felix Ratjen, Darakhshanda Shehnaz, Paul B. Pencharz, Anne Mehl
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 183:1363-1368
Rationale: Airway nitric oxide is reduced in cystic fibrosis airways. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that may contribute to nitric oxide deficiency in cystic fibrosis.Objectives: To test the hypothesis th
Autor:
Danielle Stevens, Jingyi Pan, Julijana Ivanovska, Robert P. Jankov, Hartmut Grasemann, Darakhshanda Shehnaz, Jaques Belik, Crystal Kantores, Christine Ibrahim
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 297:L777-L784
In rats, chronic hypercapnia has been reported to ameliorate hypoxia-induced pulmonary hypertension in newborn and adult and to enhance endothelium-dependent vasorelaxation in adult pulmonary arteries. The underlying mechanisms accounting for chronic
Publikováno v:
Biochemical and Biophysical Research Communications. 385:576-580
Platelet activating factor (PAF), an endogenous bioactive phospholipid, has been documented as a pivotal mediator in the inflammatory cascade underlying the pathogenesis of many diseases including necrotizing enterocolitis. Much effort has been direc
Autor:
Alex G. Lee, Kevin Leung, Jake Ching-Hsuan Hsu, Darakhshanda Shehnaz, Michael T. Griffin, Frederick J. Ehlert
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:592-600
We investigated the ability of the muscarinic antagonist p-fluorohexahydrosiladifenidol to inhibit muscarinic agonist-induced contractions and phosphoinositide hydrolysis in the guinea pig ileum and trachea. This antagonist displayed higher potency a
Autor:
Frederick J. Ehlert, Michael T. Griffin, Minoru Matsui, Makoto Mark Taketo, Darakhshanda Shehnaz
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 305:106-113
The ability of forskolin and isoproterenol to inhibit the contractile action of the muscarinic agonist, oxotremorine-M, was investigated in smooth muscle from wild-type and M(2) muscarinic receptor knockout mice. Forskolin (5.0 micro M) caused a sign
Autor:
Darakhshanda Shehnaz, Alexander C. Zambon, Bonnie L. Firestein, Mingzhao Xing, María A. Balboa, Richard J. Hughes, Paul A. Insel, Caroline Gregorian, Rennolds S. Ostrom, Brian Torres, Steven R. Post
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 28:351-354
1. Madin-Darby canine kidney (MDCK) cells, a well- differentiated renal epithelial cell line derived from distal tubule/collecting duct, respond to extracellular nucleotides by altering ion flux and the production of arachidonic acid-derived products
Publikováno v:
Toxicon. 37:1095-1107
Crude venom from Eristocophis macmahoni was demonstrated to exert a potent inhibition of human blood platelet aggregation mediated by adenosine diphosphate (ADP), platelet activating factor (PAF) and arachidonic acid (AA). The venom caused lysis of t
Publikováno v:
Phytotherapy Research. 13:445-447
An extract of Cestrum parqui aerial parts in methanol:water (1:1) showed inhibition of carrageenin-induced oedema. The aggregation of human blood platelets induced by adenosine diphosphate and platelet activating factor was also inhibited (IC50s were
Autor:
Michael T. Griffin, Darakhshanda Shehnaz, Frederick J. Ehlert, Minoru Matsui, Toshiya Manabe, Makoto Mark Taketo, Khurram Z. Ansari
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 308(1)
We investigated the subtypes of the muscarinic receptor mediating short-term heterologous desensitization in the isolated ileum. Treatment of the ileum from C57BL/6 mice with acetylcholine (30 microM) for 20 min caused a subsequent decrease in contra