Výsledky vyhledávání - "Darah A. Scruggs"

Abstract A31: C-MYC Targeting by Degradation: Novel Dual c-MYC/GSPT1 Degrader GT19715 Induces TP53-independent Cell Death in MYC-amplified Acute Myeloid Leukemia and Lymphomas

Autor: Yuki Nishida, Darah A Scruggs, Edward Ayoub, Lauren B Ostermann, Tallie Patsilevas, Vivian R Ruvolo, Po Yee Mak, Bing Z. Carter, Steffen Boettcher, Abhishek Maiti, Koji Sasaki, Qianxiang Zhou, Zhaohui Yang, Honghua Yan, Liandong Ma, Michael Andreeff

Publikováno v: Blood Cancer Discovery. 4:A31-A31

The oncoprotein c-MYC, a major regulator of the epigenome and transcriptome, is dysregulated in 70% of all human cancers. MYC is highly expressed in Burkitt lymphoma and TP53 mutant and venetoclax (ven) resistant AML (Sallman, Blood 2021, Nishida, AS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e02fbb15e3e38b5631ea7fc10c9e702b
https://doi.org/10.1158/2643-3249.aml23-a31

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C-MYC Targeting By Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Induces TP53-Independent Cell Death in Acute Myeloid Leukemia and Lymphomas

Autor: Yuki Nishida, Darah A Scruggs, Edward Ayoub, Tallie Patsilevas, Vivian Ruvolo, Po Yee Mak, Bing Z Carter, Steffen Boettcher, Abhishek Maiti, Qianxiang Zhou, Zhaohui Yang, Honghua Yan, Liandong Ma, Michael Andreeff

Publikováno v: Blood. 140:483-484

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fbf0a1f31d9261063c480838cf43fce
https://doi.org/10.1182/blood-2022-164968

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Enhanced TP53 Reactivation Disrupts MYC Transcriptional Program and Overcomes Venetoclax Resistance in Acute Myeloid Leukemias

Autor: Yuki Nishida, Jo Ishizawa, Edward Ayoub, Tallie Patsilevas, Lauren Ostermann, Rafael Heinz Montoya, Muharrum Muftuoglu, Vivian R. Ruvolo, Po Yee Mak, Wenjing Tao, Bing Z. Carter, Darah A. Scruggs, Kensuke Kojima, Naval Daver, Takahiko Seki, Sharon Shacham, Marina Konopleva, Michael Andreeff

Publikováno v: Leading Edge of Cancer Research Symposium: Poster Session.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0859616225815cd889b2d191bf9d5083
https://doi.org/10.52519/00070

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C-MYC Targeting by Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Exerts Profound Cell Kill in vitro and in vivo in Acute Myeloid Leukemia and Lymphomas

Autor: Yuki Nishida, Darah A. Scruggs, Edward Ayoub, Tallie Patsilevas, Lauren Ostermann, Vivian R. Ruvolo, Po Yee Mak, Bing Z. Carter, Steffan Boettcher, Abhishek Maiti, Qianxiang Zhou, Zhaohui Yang, Honghua Yan, Liandong Ma, Michael Andreeff

Publikováno v: Leading Edge of Cancer Research Symposium: Poster Session.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6ef660ef019dd90447fc653f79db8cd
https://doi.org/10.52519/00071

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AML-147 C-MYC Targeting by Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Exerts Profound Cell Kill In Vitro and In Vivo in Acute Myeloid Leukemia and Lymphomas

Autor: Yuki Nishida, Darah A Scruggs, Edward Ayoub, Tallie Patsilevas, Vivian R Ruvolo, Po Yee Mak, Bing Z Carter, Steffen Boettcher, Abhishek Maiti, Qianxiang Zhou, Zhaohui Yang, Honghua Yan, Liandong Ma, Michael Andreeff

Publikováno v: Clinical Lymphoma Myeloma and Leukemia. 22:S218

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ecdfeddd7336ec245291d7b267d8872
https://doi.org/10.1016/s2152-2650(22)01230-7

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Poster: AML-147 C-MYC Targeting by Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Exerts Profound Cell Kill In Vitro and In Vivo in Acute Myeloid Leukemia and Lymphomas

Publikováno v: Clinical Lymphoma Myeloma and Leukemia. 22:S127

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ade091864b9f80312b90c088ed150704
https://doi.org/10.1016/s2152-2650(22)00756-x

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333-OR: Regulation of Adiponectin Receptor 2 Expression and Function in the Liver

Autor: Darah A. Scruggs, Jiyoon Ryu, Jason T Hadley, Lily Q. Dong

Publikováno v: Diabetes. 70

Adiponectin, an adipokine, has been implicated in improving lipid and glucose metabolism and preventing diet-induced inflammation. Adiponectin transduces its effects by binding to its cognate receptors, AdipoR1 and AdipoR2. Compared to AdipoR1, Adipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa114d20bc4969c726022b90739a5d59
https://doi.org/10.2337/db21-333-or

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