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Akademický článek

Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.

Autor: Mariana Rodova, Junsheng Fu, Dara Nall Watkins, Rakesh K Srivastava, Sharmila Shankar

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e46083 (2012)

Dysregulation of the sonic hedgehog (Shh) signaling pathway has been associated with cancer stem cells (CSC) and implicated in the initiation of pancreatic cancer. Pancreatic CSCs are rare tumor cells characterized by their ability to self-renew, and

Externí odkaz: https://doaj.org/article/3d46057dd16c445b8471c22b6f998b87

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Akademický článek

Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition.

Autor: Sharmila Shankar, Dara Nall, Su-Ni Tang, Daniel Meeker, Jenna Passarini, Jay Sharma, Rakesh K Srivastava

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16530 (2011)

BACKGROUND: Cancer stem cells (CSCs) can proliferate and self-renew extensively due to their ability to express anti-apoptotic and drug resistant proteins, thus sustaining tumor growth. Therefore, the strategy to eradicate CSCs might have significant

Externí odkaz: https://doaj.org/article/f96b23b731a349e9806c7dbcebb85fcd

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Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog–GLI pathway

Autor: Dara Nall Watkins, Junsheng Fu, Shih-Hui Li, Rakesh K. Srivastava, Sharmila Shankar

Publikováno v: Molecular and Cellular Biochemistry. 373:217-227

Sulforaphane (SFN), a component of dietary cruciferous vegetables has been characterized for its anti-proliferative properties. We have recently demonstrated that pancreatic CSCs display activation of sonic hedgehog pathway which are fundamental driv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881a1f62c728470a296c8b85a131a63b
https://doi.org/10.1007/s11010-012-1493-6

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Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics

Autor: Junsheng Fu, Mariana Rodova, Sharmila Shankar, Su-Ni Tang, Rakesh K. Srivastava, Dara Nall

Publikováno v: International journal of cancer. 131(1)

Activation of the sonic hedgehog (Shh) pathway is required for the growth of numerous tissues and organs and recent evidence indicates that this pathway is often recruited to stimulate growth of cancer stem cells (CSCs) and to orchestrate the reprogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfbbc54c25836aa9e84f0c41cccf3a2
https://pubmed.ncbi.nlm.nih.gov/21796625

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Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition

Autor: Jenna Passarini, Su-Ni Tang, Dara Nall, Sharmila Shankar, Daniel Meeker, Rakesh K. Srivastava, Jay Sharma

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16530 (2011)
PLoS ONE

Background Cancer stem cells (CSCs) can proliferate and self-renew extensively due to their ability to express anti-apoptotic and drug resistant proteins, thus sustaining tumor growth. Therefore, the strategy to eradicate CSCs might have significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694903f1669ef111783150ee1f97f269
http://europepmc.org/articles/PMC3031576?pdf=render

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Abstract 200: EGCG inhibits pancreatic cancer stem cell characteristics in human primary tumors, and carcinogenesis in KrasG12D transgenic mice

Autor: Dara Nall, Rakesh K. Srivastava, Su-Ni Tang, Chris Jackman, Luke Marsh, Sharmila Shankar

Publikováno v: Cancer Research. 73:200-200

EGCG, a component of green tea, exerts antiproliferative and proapoptotic actions on a number of different cancer cell lines through diverse mechanisms. However, the mechanisms by which EGCG inhibits cell proliferation and induces apoptosis are poorl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9c31541e01ec9889cabe0f5160bbfa1
https://doi.org/10.1158/1538-7445.am2013-200

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Abstract A45: Resveratrol inhibits prostate cancer stem cell characteristics by suppressing Wnt, sonic hedgehog, and Notch pathways

Autor: Rakesh K. Srivastava, Junsheng Fu, Mariana Rodova, Sharmila Shankar, Dara Nall

Publikováno v: Cancer Research. 72:A45-A45

The existence of cancer stem cells (CSCs) in prostate cancer has profound implications for cancer prevention and/or treatment. The CSC population resides within the prostate tumor mass and they may be responsible for drug resistance, and for the recu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffe24c67a6abd202cd76ed990d2dabba
https://doi.org/10.1158/1538-7445.prca2012-a45

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The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition

Autor: Su-Ni Tang, Chandan Singh, Rakesh K. Srivastava, Daniel Meeker, Dara Nall, Sharmila Shankar

Publikováno v: Journal of Molecular Signaling
Journal of Molecular Signaling; Vol 5 (2010); Art. 14

Background: Much attention has been recently focused on the role of cancer stem cells (CSCs) in the initiation and progression of solid malignancies. Since CSCs are able to proliferate and self-renew extensively due to their ability to express anti-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7eee874b66d7097ea751134db2e1e4
https://doi.org/10.1186/1750-2187-5-14

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Akademický článek

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