Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Dara L. Dickstein"'
Autor:
Kathleen Hatch, Fritz Lischka, Mengfan Wang, Xiufen Xu, Cheryl D. Stimpson, Tara Barvir, Nathan P. Cramer, Daniel P. Perl, Guoqiang Yu, Caroline A. Browne, Dara L. Dickstein, Zygmunt Galdzicki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Due to their interactions with the neurovasculature, microglia are implicated in maladaptive responses to hypobaric hypoxia at high altitude (HA). To explore these interactions at HA, pharmacological depletion of microglia with the colony-st
Externí odkaz:
https://doaj.org/article/f51280faee024a93b5039b6c5fb33143
Autor:
Brett A. Eyford, Maciej J. Lazarczyk, Kyung Bok Choi, Merina Varghese, Hitesh Arora, Suresh Kari, Lonna Munro, Cheryl G. Pfeifer, Allison Sowa, Daniel R. Dickstein, Dara L. Dickstein, Wilfred A. Jefferies
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The interplay between AMPA-type glutamate receptors (AMPARs) and major histocompatibility complex class I (MHC-I) proteins in regulating synaptic signaling is a crucial aspect of central nervous system (CNS) function. In this study, we inves
Externí odkaz:
https://doaj.org/article/b13129d68b9c4a1ab46349a7afd15b09
Autor:
Maciej J. Lazarczyk, Brett A. Eyford, Merina Varghese, Hitesh Arora, Lonna Munro, Tahia Warda, Cheryl G. Pfeifer, Allison Sowa, Daniel R. Dickstein, Timothy Rumbell, Wilfred A. Jefferies, Dara L. Dickstein
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Major histocompatibility complex class I (MHC-I) proteins are expressed in neurons, where they regulate synaptic plasticity. However, the mechanisms by which MHC-I functions in the CNS remains unknown. Here we describe the first structural a
Externí odkaz:
https://doaj.org/article/efb7fabefb7e4b9fb5bff7fbd1571479
Autor:
Georgina Perez Garcia, Rita De Gasperi, Miguel A. Gama Sosa, Gissel M. Perez, Alena Otero-Pagan, Dylan Pryor, Rania Abutarboush, Usmah Kawoos, Patrick R. Hof, Dara L. Dickstein, David G. Cook, Sam Gandy, Stephen T. Ahlers, Gregory A. Elder
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-24 (2021)
Abstract Military veterans who experience blast-related traumatic brain injuries often suffer from chronic cognitive and neurobehavioral syndromes. Reports of abnormal tau processing following blast injury have raised concerns that some cases may hav
Externí odkaz:
https://doaj.org/article/0127541a2b2f4a099201801c41a05d43
Autor:
Sarah Jacot-Descombes, Neha U. Keshav, Dara L. Dickstein, Bridget Wicinski, William G. M. Janssen, Liam L. Hiester, Edward K. Sarfo, Tahia Warda, Matthew M. Fam, Hala Harony-Nicolas, Joseph D. Buxbaum, Patrick R. Hof, Merina Varghese
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract Background Deletion or mutations of SHANK3 lead to Phelan–McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Altered morphology of
Externí odkaz:
https://doaj.org/article/76fed77b88154180aa37dd19e6edee68
Autor:
Balaji Krishnan, Chandramouli Natarajan, Krystyn Z. Bourne, Leila Alikhani, Juan Wang, Allison Sowa, Katherine Groen, Bayley Perry, Dara L. Dickstein, Janet E. Baulch, Charles L. Limoli, Richard A. Britten
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3668 (2021)
The proposed deep space exploration to the moon and later to Mars will result in astronauts receiving significant chronic exposures to space radiation (SR). SR exposure results in multiple neurocognitive impairments. Recently, our cross-species (mous
Externí odkaz:
https://doaj.org/article/0c06f40d7104429c89de546fdd6dc4c0
Autor:
Erin A. Hazlett, Iliyan Ivanov, Corey Fernandez, Effie M. Mitsis, Dara L. Dickstein, Edmund Wong, Cheuk Y. Tang, Jessie Simantov, Charlene Bang, Erin Moshier, Mary Sano, Gregory A. Elder
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
The long-term effects of blast exposure are a major health concern for combat veterans returning from the recent conflicts in Iraq and Afghanistan. We used an optimized diffusion tensor imaging tractography algorithm to assess white matter (WM) fract
Externí odkaz:
https://doaj.org/article/9fe9e595471d41ca8cb0b0335987c620
Autor:
Brett A. Eyford, Maciej J. Lazarczyk, Merina Varghese, Kyung Bok Choi, Hitesh Arora, Lonna Munro, Cheryl G. Pfeifer, Allison Sowa, Daniel R. Dickstein, Dara L. Dickstein, Wilfred A. Jefferies, Suresh Kari
AMPA-type glutamate receptors (AMPARs) and major histocompatibility complex class I (MHC-I) proteins regulate synaptic signalling. Here we describe the importance of the cytoplasmic tail of MHC-I for its role in the central nervous system (CNS) in sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f84d1522dfa80897de7a508a74fb3735
https://doi.org/10.21203/rs.3.rs-2699534/v1
https://doi.org/10.21203/rs.3.rs-2699534/v1
Autor:
Yasaman Alaghband, Peter M. Klein, Eniko A. Kramár, Michael N. Cranston, Bayley C. Perry, Lukas M. Shelerud, Alice E. Kane, Ngoc-Lien Doan, Ning Ru, Munjal M. Acharya, Marcelo A. Wood, David A. Sinclair, Dara L. Dickstein, Ivan Soltesz, Charles L. Limoli, Janet E. Baulch
Publikováno v:
Cellular and molecular life sciences : CMLS, vol 80, iss 1
Technological advancements have facilitated the implementation of realistic, terrestrial-based complex 33-beam galactic cosmic radiation simulations (GCR Sim) to now probe central nervous system functionality. This work expands considerably on prior,
Autor:
Bernard J. Dardzinski, Nathan P. Cramer, Diego Iacono, Dara L. Dickstein, Zygmunt Galdzicki, Daniel P. Perl, Xiufen Xu, Erin K Murphy, Rupali Sharma, Bayley Perry, Zahra Adahman
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Long-term operations carried out at high altitude (HA) by military personnel, pilots, and astronauts may trigger health complications. In particular, chronic exposure to high altitude (CEHA) has been associated with deficits in cognitive function. In