Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Dara L. Burdette"'
Autor:
Christian K. Holm, Stine H. Rahbek, Hans Henrik Gad, Rasmus O. Bak, Martin R. Jakobsen, Zhaozaho Jiang, Anne Louise Hansen, Simon K. Jensen, Chenglong Sun, Martin K. Thomsen, Anders Laustsen, Camilla G. Nielsen, Kasper Severinsen, Yingluo Xiong, Dara L. Burdette, Veit Hornung, Robert Jan Lebbink, Mogens Duch, Katherine A. Fitzgerald, Shervin Bahrami, Jakob Giehm Mikkelsen, Rune Hartmann, Søren R. Paludan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Stimulator of interferon genes (STING) is known to be involved in defence against DNA viruses, but its role in the control of RNA viruses remains poorly explored. Here the authors show that STING participates in an innate immune response to RNA virus
Externí odkaz:
https://doaj.org/article/00f2e460d4a44590a591e3a422a9f087
Autor:
Elie J. Diner, Dara L. Burdette, Stephen C. Wilson, Kathryn M. Monroe, Colleen A. Kellenberger, Mamoru Hyodo, Yoshihiro Hayakawa, Ming C. Hammond, Russell E. Vance
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1355-1361 (2013)
The presence of foreign DNA in the cytosol of mammalian cells elicits a potent antiviral interferon response. Recently, cytosolic DNA was proposed to induce the synthesis of cyclic GMP-AMP (cGAMP) upon binding to an enzyme called cGAMP synthase (cGAS
Externí odkaz:
https://doaj.org/article/2a539847a7d542709f20c5ca08f20165
Autor:
Jeffrey R. Barker, Benjamin J. Koestler, Victoria K. Carpenter, Dara L. Burdette, Christopher M. Waters, Russell E. Vance, Raphael H. Valdivia
Publikováno v:
mBio, Vol 4, Iss 3 (2013)
ABSTRACT STING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-depend
Externí odkaz:
https://doaj.org/article/bdb5532bc2164aa296238bf6a6386812
Autor:
Dara L Burdette, Scott Lazerwith, Jenny Yang, Henry L. Y. Chan, William E. Delaney IV, Simon P. Fletcher, Tomas Cihlar, Becket Feierbach
Publikováno v:
PLOS ONE. 17:e0262516
Nucleos(t)ide analogs are standard-of-care for the treatment of chronic hepatitis B and can effectively reduce hepatitis B virus (HBV) replication but rarely leads to cure. Nucleos(t)ide analogs do not directly eliminate the viral episome, therefore