Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Dar-chone Chow"'
Autor:
Alan F Humphreys, Jie Tan, RongSheng Peng, Susan M Benton, Xiang Qin, Kim C Worley, Rose L Mikulski, Dar-Chone Chow, Timothy G Palzkill, Paul D Ling
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116318 (2015)
Asian elephant (Elephas maximus) immunity is poorly characterized and understood. This gap in knowledge is particularly concerning as Asian elephants are an endangered species threatened by a newly discovered herpesvirus known as elephant endotheliot
Externí odkaz:
https://doaj.org/article/a010fa0c0cea492dbc55c20bd4349c90
Autor:
Fei Yan, Yang Yu, Dar-Chone Chow, Timothy Palzkill, Franck Madoux, Peter Hodder, Peter Chase, Patrick R Griffin, Bert W O'Malley, David M Lonard
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95243 (2014)
Members of the steroid receptor coactivator (SRC) family are overexpressed in numerous types of cancers. In particular, steroid receptor coactivator 3 (SRC-3) has been recognized as a critical coactivator associated with tumor initiation, progression
Externí odkaz:
https://doaj.org/article/3fd456d37c814d1e83cd1be566899bbc
Autor:
Jeong Joo Kim, Darren E Casteel, Gilbert Huang, Taek Hun Kwon, Ronnie Kuo Ren, Peter Zwart, Jeffrey J Headd, Nicholas Gene Brown, Dar-Chone Chow, Timothy Palzkill, Choel Kim
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18413 (2011)
Cyclic GMP-dependent protein kinases (PKGs) are central mediators of the NO-cGMP signaling pathway and phosphorylate downstream substrates that are crucial for regulating smooth muscle tone, platelet activation, nociception and memory formation. As o
Externí odkaz:
https://doaj.org/article/e1dd73eefa1a4f26b78f460e8b8a54e8
Publikováno v:
ACS Infectious Diseases. 2:969-979
The β-lactamase inhibitory protein (BLIP) binds and inhibits a wide range of class A β-lactamases including the TEM-1 β-lactamase (Ki = 0.5 nM), which is widely present in Gram-negative bacteria, and the KPC-2 β-lactamase (Ki = 1.2 nM), which hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12894d30006feed310f280b94ca8288b
https://doi.org/10.1021/acsinfecdis.6b00160
https://doi.org/10.1021/acsinfecdis.6b00160
Autor:
Michael A. Mancini, Yang Yu, Jianming Xu, Lan Liao, Lei Wang, Chih Chao Hsu, Suoling Zhou, Dar Chone Chow, David M. Lonard, Bert W. O'Malley, Fabio Stossi, Timothy Palzkill, Fei Yan
Publikováno v:
Cancer Cell. 28(2):240-252
SummaryBy integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer therapeutics. High-throughput screening for SRC small molecule inhibitors (SMIs) uncovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa21e0a4729fa157e4bd22b8f2df27d3
Autor:
Timothy Palzkill, Dar-Chone Chow, Bartlomiej G. Fryszczyn, Liya Hu, Laurent Poirel, B. V. Venkataram Prasad, Patrice Nordmann, V. Stojanoski, Banumathi Sankaran
Publikováno v:
Biochemistry. 54:3370-3380
OXA-163 and OXA-48 are closely related class D β-lactamases that exhibit different substrate profiles. OXA-163 hydrolyzes oxyimino-cephalosporins, particularly ceftazidime, while OXA-48 prefers carbapenem substrates. OXA-163 differs from OXA-48 by o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec9214832787d4a41d9c08e8bdb684b
https://doi.org/10.1021/acs.biochem.5b00298
https://doi.org/10.1021/acs.biochem.5b00298
Autor:
Timothy Palzkill, Patrick R. Griffin, Bert W. O'Malley, Yang Yu, Lan Liao, Peter Chase, Alexander J. Matzuk, Ying Wang, Suoling Zhou, Franck Madoux, Peter Hodder, Jianming Xu, David M. Lonard, Dar-Chone Chow, Xianzhou Song, Jin Wang, Ruogu Qi
Publikováno v:
Cancer Research. 74:1506-1517
Virtually all transcription factors partner with coactivators that recruit chromatin remodeling factors and interact with the basal transcription machinery. Coactivators have been implicated in cancer cell proliferation, invasion, and metastasis, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966285c2d627aca0b5e85d049a49bde7
https://doi.org/10.1158/0008-5472.can-13-2939
https://doi.org/10.1158/0008-5472.can-13-2939
Publikováno v:
Science. 8/31/2001, Vol. 293 Issue 5535, p1657-1662. 6p. 3 Diagrams, 1 Chart, 1 Graph.
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:3398-3401
β-Lactamase inhibitory protein II (BLIP-II) is a potent inhibitor of class A β-lactamases. KPC-2 is a class A β-lactamase that is capable of hydrolyzing carbapenems and has become a widespread source of resistance to these drugs for Gram-negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1394cd55d398212c887243dc8158e043
https://doi.org/10.1128/aac.00215-13
https://doi.org/10.1128/aac.00215-13
Autor:
Timothy Palzkill, Jianming Xu, Chengwei Zhang, Jin Wang, David M. Lonard, Xianzhou Song, Dar Chone Chow, Yang Yu, Bert W. O'Malley, Jianwei Chen, Mingkun Zhao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(18)
Protein-protein interactions (PPIs) play a central role in most biological processes, and therefore represent an important class of targets for therapeutic development. However, disrupting PPIs using small-molecule inhibitors (SMIs) is challenging an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56a6623d60219bdf5285fc4db6596d9
https://pubmed.ncbi.nlm.nih.gov/27084884
https://pubmed.ncbi.nlm.nih.gov/27084884