Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Daqiang Li"'
Autor:
Hao-Chi Hsu, Daqiang Li, Wenhu Zhan, Jianxiang Ye, Yi Jing Liu, Annie Leung, Junling Qin, Benigno Crespo, Francisco-Javier Gamo, Hao Zhang, Liwang Cui, Alison Roth, Laura A. Kirkman, Huilin Li, Gang Lin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The proteasome of the malaria parasite Plasmodium falciparum (Pf20S) is an advantageous drug target because its inhibition kills P. falciparum in multiple stages of its life cycle and synergizes with artemisinins. We recently developed a mac
Externí odkaz:
https://doaj.org/article/c572579ac9434308b55f8122c4687613
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background We established a radiogenomic model to predict pathological complete response (pCR) in triple-negative breast cancer (TNBC) and explored the association between high-frequency mutations and drug resistance. Methods From April 2018
Externí odkaz:
https://doaj.org/article/9cc12f86ce614f3c856ca142c7ae10e8
Publikováno v:
Platelets, Vol 32, Iss 7, Pp 968-974 (2021)
In the setting of coronary heart diseases (CHDs) on treatment with clopidogrel, ADP-induced platelet aggregation has been demonstrated with ischemic events. However, there were very limited data for predicting ischemic events by platelet function tes
Externí odkaz:
https://doaj.org/article/acc0b35cc12e405fbc9179ddd461ff87
Publikováno v:
Thrombosis Journal, Vol 19, Iss 1, Pp 1-7 (2021)
Abstract Objective Dual antiplatelet therapy can reduce coronary thrombosis and improve the prognosis in patients with acute coronary syndrome (ACS). However, there was limited prognostic information about fibrinolytic dysregulation in patients with
Externí odkaz:
https://doaj.org/article/e0558d26054248009d6d9b61c2902c15
Autor:
Xiaochen Yang, Jiong Wu, Jingsong Lu, Guangyu Liu, Genhong Di, Canming Chen, Yifeng Hou, Menghong Sun, Wentao Yang, Xiaojing Xu, Ying Zhao, Xin Hu, Daqiang Li, Zhigang Cao, Xiaoyan Zhou, Xiaoyan Huang, Zhebin Liu, Huan Chen, Yanzi Gu, Yayun Chi, Xia Yan, Qixia Han, Zhenzhou Shen, Zhimin Shao, Zhen Hu
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125571 (2015)
The genetic etiology of hereditary breast cancer has not been fully elucidated. Although germline mutations of high-penetrance genes such as BRCA1/2 are implicated in development of hereditary breast cancers, at least half of all breast cancer famili
Externí odkaz:
https://doaj.org/article/0902ef4acd924031a6a46be89f04b551
Autor:
Daqiang Li, Zhuo Zhang, Yalei Li, Xinyi Wang, Hanyue Zhong, Huajie Yang, Yong Xi, Hongchun Liu, Aijun Shen, Youhong Hu
Publikováno v:
Journal of Medicinal Chemistry. 66:7016-7037
Autor:
Wenhu Zhan, Daqiang Li, Priya Saha, Rong Wang, Hao Zhang, Amrendra K. Ajay, Christa Deban, George Sukenick, Jamil Azzi, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 66:1172-1185
We describe our discovery and development of potent and highly selective inhibitors of human constitutive proteasome chymotryptic activity (β5c). Structure-activity relationship studies of the novel class of inhibitors focused on optimization of
Autor:
Wenhu Zhan, Daqiang Li, Shubha Bevkal Subramanyaswamy, Yi Jing Liu, Changmei Yang, Hao Zhang, Jacob C. Harris, Rong Wang, Songbiao Zhu, Hedy Rocha, Julian Sherman, Junling Qin, Mikayla Herring, Nelson V. Simwela, Andrew P. Waters, George Sukenick, Liwang Cui, Ana Rodriguez, Haiteng Deng, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Cell Chemical Biology. 30:457-469.e11
Autor:
Yan-Ni Huang, Peng Xu, Qingping Zou, Qi Lu, Wei Li, Wenxuan Li, Daqiang Li, Ying Liang, Mengxing Liu, Wenqiang Yu, Xiaoguang Ren, Shihua Dong, Dapeng Zhang, Baolong Zhang, Hailin Wang, Fang-Lin Zhang, Zhicong Yang, Shaoxuan Wang, Lu Chen, Ying Tong
Publikováno v:
Nucleic Acids Research
Dysfunction of Tumour Suppressor Genes (TSGs) is a common feature in carcinogenesis. Epigenetic abnormalities including DNA hypermethylation or aberrant histone modifications in promoter regions have been described for interpreting TSG inactivation.
Publikováno v:
Cancer science. 113(11)
RNA binding proteins (RBPs) play pivotal roles in breast cancer (BC) development. As an RBP, Processing of precursor 7 (POP7) is one of the subunits of RNase P and RNase MRP, however, its exact function and mechanism in BC remain unknown. Here, we sh