Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis

Autor: Wouter H. Gerritsen, Paul van der Valk, Sandra Amor, Kimberley Ummenthum, Daphne Y.S. Vogel, Priscilla D. A. M. Heijnen, Laura A. N. Peferoen, Christine D. Dijkstra, Marjolein Breur, Regina Peferoen-Baert

Publikováno v: Journal of Neuropathology and Experimental Neurology, 74(1), 48-63. Lippincott Williams and Wilkins
Peferoen, L A N, Vogel, D Y S, Ummenthum, K, Breur, M, Heijnen, P D A M, Gerritsen, W H, Peferoen-Baert, R M B, van der Valk, P, Dijkstra, C D & Amor, S 2015, ' Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis ', Journal of Neuropathology and Experimental Neurology, vol. 74, no. 1, pp. 48-63 . https://doi.org/10.1097/NEN.0000000000000149

Similar to macrophages, microglia adopt diverse activation states and contribute to repair and tissue damage in multiple sclerosis. Using reverse transcription-quantitative polymerase chain reaction and immunohistochemistry, we show that in vitro M1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1780cc193d3fffc34ff8da559fb77337
https://doi.org/10.1097/nen.0000000000000149

Metal ions potentiate microglia responsiveness to endotoxin

Autor: B. Mary E. von Blomberg, Dessy Rachmawati, Rik J. Scheper, Hetty J. Bontkes, Daphne Y.S. Vogel, Inás W.A. Alsalem, Laura A. N. Peferoen, Sandra Amor, Ingrid M.W. van Hoogstraten

Publikováno v: Rachmawati, D, Peferoen, L A N, Vogel, D Y S, Alsalem, I W A, Amor, S, Bontkes, H J, von Blomberg, BME, Scheper, R J & van Hoogstraten, I M W 2016, ' Metal ions potentiate microglia responsiveness to endotoxin ', Journal of Neuroimmunology, vol. 291, pp. 89-95 . https://doi.org/10.1016/j.jneuroim.2015.12.013
Journal of Neuroimmunology, 291, 89-95. Elsevier

Oral metal exposure has been associated with diverse adverse reactions, including neurotoxicity. We showed previously that dentally applied metals activate dendritic cells (MoDC) via TLR4 (Ni, Co, Pd) and TLR3 (Au). It is still unknown whether the lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbb4ac95780311f5b27a80887627ab9
https://pubmed.ncbi.nlm.nih.gov/26857501

Inflammation in neurodegenerative diseases-an update

Autor: Laura A. N. Peferoen, Paul van der Valk, Johannes M. van Noort, David Baker, Daphne Y.S. Vogel, Sandra Amor, Marjolein Breur

Publikováno v: Immunology, 142(2), 151-166. Wiley-Blackwell
Amor, S, Peferoen, L A N, Vogel, D Y S, Breur, M, van der Valk, P, Baker, D & van Noort, J M 2014, ' Inflammation in neurodegenerative diseases-an update ', Immunology, vol. 142, no. 2, pp. 151-166 . https://doi.org/10.1111/imm.12233

Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous system (CNS), is the major cause of cognitive and motor dysfunction. While neuronal degeneration is well-known in Alzheimer's and Parkinson's diseases, it is al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4298407e30cfacbf1c4d03c840b235
https://research.vumc.nl/en/publications/feede56d-e040-4bb8-b90c-854b5bd3af89

In vitro and in vivo models of multiple sclerosis

Autor: Baukje J. van der Star, Fabiola Puentes, Daphne Y.S. Vogel, Markus Kipp, Sandra Amor, David Baker

Publikováno v: CNS and Neurological Disorders. Drug Targets, 11(5), 570-588. Bentham Science Publishers B.V.
van der Star, B J, Vogel, D Y S, Kipp, M, Puentes, F, Baker, D & Amor, S 2012, ' In vitro and in vivo models of multiple sclerosis ', CNS and Neurological Disorders. Drug Targets, vol. 11, no. 5, pp. 570-588 . https://doi.org/10.2174/187152712801661284

Multiple sclerosis (MS) is widely considered to be the result of an aggressive autoreactive T cell attack on myelin. How these autoimmune responses arise in MS is unclear, but they could result from virus infections. Thus, viral and autoimmune diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee4995663fe6011265ae407d3d6f328
https://research.vumc.nl/en/publications/e3c6011b-e270-4539-a7f1-a6882b6a8cab

Galectin-2 Induces a Proinflammatory, Anti-Arteriogenic Phenotype in Monocytes and Macrophages

Autor: Tineke C. T. M. van der Pouw Kraan, Anja M. van der Laan, Ruud D. Fontijn, Juan J. Garcia-Vallejo, Maurits R. Hollander, Daphne Y.S. Vogel, Christine D. Dijkstra, J.M. Baggen, Sylvia Nieuwenhuis, Cansu Yıldırım, Niels van Royen, Paul H.A. Quax, Anton J.G. Horrevoets, Anouk Haverkamp, Margreet R. de Vries

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124347 (2015)
Yildirim, C, Vogel, D Y S, Hollander, M R, Baggen, J M, Fontijn, R D, Nieuwenhuis, S, Haverkamp, A, de Vries, M R, Quax, P H A, Garcia Vallejo, J J, van der Laan, A M, Dijkstra, C D, van der Pouw-Kraan, T C T M, van Royen, N & Horrevoets, A J G 2015, ' Galectin-2 Induces a Proinflammatory, Anti-Arteriogenic Phenotype in Monocytes and Macrophages ', PLoS ONE, vol. 10, no. 4, e0124347 . https://doi.org/10.1371/journal.pone.0124347
PLoS ONE, 10(4):e0124347. Public Library of Science
PLoS ONE, 10(4). Public Library of Science
PLoS ONE

Galectin-2 is a monocyte-expressed carbohydrate-binding lectin, for which increased expression is genetically determined and associated with decreased collateral arteriogenesis in obstructive coronary artery disease patients. The inhibiting effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43cd5abb8a4c055d2e85145ae5a2f7a1
https://doi.org/10.1371/journal.pone.0124347