Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Daphne S, Cukierman"'
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Akademický článek
Effects of the aldehyde-derived ring substituent on the properties of two new bioinspired trimethoxybenzoylhydrazones: methyl vs nitro groups
Autor: Dayanne Martins, Roberta Lamosa, Talis Uelisson da Silva, Carolina B. P. Ligiero, Sérgio de Paula Machado, Daphne S. Cukierman, Nicolás A. Rey
Publikováno v: Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1713-1727 (2023)
N-Acylhydrazones are a versatile class of organic compounds with a diversity of potential applications. In this study, two new structure-related 3,4,5-trimethoxybenzoyl-containing N-acylhydrazones were synthesized and fully characterized, both in sol
Externí odkaz: https://doaj.org/article/91705115ce77426b90cc623830806264
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6
New mescaline-related N-acylhydrazone and its unsubstituted benzoyl derivative: Promising metallophores for copper-associated deleterious effects relief in Alzheimer's disease
Autor: Alessandra Carvalho, Barbara Marinho Barbosa, Jesica S. Flores, Phelippe do Carmo Gonçalves, Renata Diniz, Yraima Cordeiro, Claudio O. Fernández, Daphne S. Cukierman, Nicolás A. Rey
Publikováno v: Journal of inorganic biochemistry. 238
Alzheimer's disease (AD) is related to the presence of extracellular aggregated amyloid-β peptide (Aβ), which binds copper(II) with high affinity in its N-terminal region. In this sense, two new 1-methylimidazole-containing N-acylhydrazonic metallo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f525540b305fb9a74e75c9f22b75530c
https://pubmed.ncbi.nlm.nih.gov/36396525
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8
Impact of pyridine-2-carboxaldehyde-derived aroylhydrazones on the copper-catalyzed oxidation of the M112A PrP103–112 mutant fragment
Autor: Nikolett Bodnár, Beatriz N. Evangelista, Csilla Kállay, Daphne S. Cukierman, Nicolás A Rey, Lajos Nagy
Publikováno v: Journal of Biological Inorganic Chemistry
Misfolded prion protein (PrPSc) is known for its role in fatal neurodegenerative conditions, such as Creutzfeldt-Jakob disease. PrP fragments and their mutants represent important tools in the investigation of the neurotoxic mechanisms and in the eva
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2d335c12880da354b7fff4bf277fb0
https://doi.org/10.1007/s00775-019-01700-2
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9
X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(I)/copper(II)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy
Autor: Nicolás A. Rey, Tiago F. Outeiro, Renata Diniz, Patrícia R Ferreira, Claudio O. Fernández, Pamela Sacco, Diana F. Lázaro, Daphne S Cukierman
Publikováno v: Dalton transactions (Cambridge, England : 2003). 49(45)
Although normal aging presents an accumulation of copper and iron in the brain, this becomes more relevant in neurodegeneration. α-Synuclein (α-Syn) misfolding has long been linked with the development of Parkinson's disease (PD). Copper binding pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d33e800a58d6f0f8659e01dcb7279f
https://pubmed.ncbi.nlm.nih.gov/32391542
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