Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Daphne Lelieveld"'
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Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia
Autor: Marije Bartels, Edwin Sonneveld, Paul J. Coffer, Daphne Lelieveld, David A. Egan, Anita M.A.P. Govers, C. Michel Zwaan, Caroline R.M. Wiggers
Publikováno v: Pediatric Blood & Cancer, 66(8):e27785. Wiley-Liss Inc.
Pediatric Blood & Cancer, 66(8). Wiley-Liss Inc.
Background Acute myeloid leukemia (AML) is a heterogeneous disease regarding morphology, immunophenotyping, genetic abnormalities, and clinical behavior. The overall survival rate of pediatric AML is 60% to 70%, and has not significantly improved ove
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78526aab3cacf01f1e6b42ced7b15cf
https://pure.eur.nl/en/publications/00c40e60-9a48-43da-98df-fa8208cc2955
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6
Abstract 2630: Preclinical identification of Venetoclax combination strategies with Idasanutlin, CUDC-907, Prexasertib or Talazoparib for neuroblastoma treatment
Autor: Bianca Koopmans, Lindy Vernooij, Laurel T. Bate-Eya, Jan J. Molenaar, M. Emmy M. Dolman, Ronald W. Stam, Daphne Lelieveld, Mark Kerstjens, Anke H. W. Essing, Huib N. Caron, David A. Egan, Lindy K. Alles
Publikováno v: Cancer Research. 78:2630-2630
BACKGROUND: The anti-apoptotic protein B cell lymphoma/leukaemia 2 (BCL-2) is highly expressed in the majority of all neuroblastomas. In previous preclinical studies, we have shown that treatment of BCL-2-dependent neuroblastoma with BCL-2 inhibitors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5f17769be00ddaa7146862916309c94
https://doi.org/10.1158/1538-7445.am2018-2630
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A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels
Autor: David A. Egan, Bas Castelijns, Michiel Vermeulen, Daphne Lelieveld, Hetty A.A.M. van Teeffelen, H. Th. Marc Timmers, F. M. van Schaik, Petra de Graaf, Philip Lijnzaad, Roy Baas
Publikováno v: Journal of Biomolecular Screening, 19, 287-96
Journal of Biomolecular Screening, 19, 2, pp. 287-96
Posttranslational modifications of histones play an important role in the regulation of gene expression and chromatin structure in eukaryotes. The balance between chromatin factors depositing (writers) and removing (erasers) histone marks regulates t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0eb66e48d5584ed448b1ba85c7cec3
https://doi.org/10.1177/1087057113515024
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8
Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C
Autor: Wienand A. Omta, Bruno Canard, Lonneke van der Linden, David A. Egan, Rachel Ulferts, Bruno Coutard, Maria J. Maté, Frank J. M. van Kuppeveld, S. Matthijn de Boer, Daphne Lelieveld, Julie Lichière, Heyrhyoung Lyoo, Lisa Bauer
Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2016, 60 (5), pp.2627-2638. ⟨10.1128/AAC.02182-15⟩
Antimicrobial Agents and Chemotherapy, 60(5), 2627. American Society for Microbiology
Antimicrobial Agents and Chemotherapy, 2016, 60 (5), pp.2627-2638. ⟨10.1128/AAC.02182-15⟩
Antimicrobial agents and chemotherapy, 60(5), 2627-2638. American Society for Microbiology
Enteroviruses (EVs) represent many important pathogens of humans. Unfortunately, no antiviral compounds currently exist to treat infections with these viruses. We screened the Prestwick Chemical Library, a library of approved drugs, for inhibitors of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37e5d2ef4e5433d5067d9d3dbed9895
https://hal.archives-ouvertes.fr/hal-01439060
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An image-based miRNA screen identifies miRNA-135s as regulators of CNS axon growth and regeneration by targeting krüppel-like factor 4
Autor: Alwin A.H.A. Derijck, Daphne Lelieveld, Youri Adolfs, Giuliano Giuliani, R. Jeroen Pasterkamp, Eoghan O'Duibhir, Marieke G. Verhagen, Toshihide Yamashita, Yuki Fujita, Roel Q.J. Schaapveld, Eljo Y. van Battum, David A. Egan, Vamshidhar R. Vangoor, Thijs de Gunst
Publikováno v: Journal of Neuroscience, 38(3), 613. Society for Neuroscience
During embryonic development, axons extend over long distances to establish functional connections. In contrast, axon regeneration in the adult mammalian CNS is limited in part by a reduced intrinsic capacity for axon growth. Therefore, insight into
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0b33a72ecfbac7a62559eb3e401528
https://doi.org/10.1523/jneurosci.0662-17.2017
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The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression
Autor: Alexandra Milona, Chiara Guercini, Ingrid T. G. W. Bijsmans, José M. Ramos Pittol, Antimo Gioiello, David A. Egan, Saskia W.C. van Mil, Roberto Pellicciari, Daphne Lelieveld, Wienand A. Omta
Publikováno v: Scientific Reports, 5. Nature Publishing Group
Scientific Reports
The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5190b63e84a62b771bdd32efc310ed8f
https://dspace.library.uu.nl/handle/1874/333254
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