Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Daphna Mokady"'
Autor:
Daphna Mokady, Jason Charish, Patrick Barretto-Burns, Kenneth N. Grisé, Brenda L. K. Coles, Susanne Raab, Arturo Ortin-Martinez, Alex Müller, Bernhard Fasching, Payal Jain, Micha Drukker, Derek van der Kooy, Matthias Steger
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1521 (2024)
Degenerative retinal diseases associated with photoreceptor loss are a leading cause of visual impairment worldwide, with limited treatment options. Phenotypic profiling coupled with medicinal chemistry were used to develop a small molecule with prol
Externí odkaz:
https://doaj.org/article/52c1c22b770c4c6e9d3d737724110ca2
Autor:
Christopher B. Marshall, Benjamin G. Neel, Troy Ketela, Anne-Claude Gingras, Jane Cullis, Mauricio Medrano, Jason Moffat, María José Sandí, Daphna Mokady, Robert Rottapel, David Meiri, Ming-Sound Tsao, Nikolina Radulovich, Jose LaRose, Oliver A. Kent, Mitsuhiko Ikura, Richard Marcotte, Josee Normand
Publikováno v:
Cancer Cell. 25:181-195
Summary Cellular transformation by oncogenic RAS engages the MAPK pathway under strict regulation by the scaffold protein KSR-1. Here, we report that the guanine nucleotide exchange factor GEF-H1 plays a critical role in a positive feedback loop for
Autor:
Mauricio Medrano, Helen E. Burston, Daphna Mokady, Kyle E. Francis, Robert Rottapel, Melany J. Wagner
Publikováno v:
Clinical Cancer Research. 24:IA27-IA27
The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and whole-kinome proteomics t
Autor:
Robert Rottapel, Michael Mullin, Anne-Claude Gingras, Daphna Mokady, Mitsuhiko Ikura, David Meiri, Christopher B. Marshall, Jose LaRose
Publikováno v:
Nature communications. 5
The RhoGEF GEF-H1 can be sequestered in an inactive state on polymerized microtubules by the dynein motor light-chain Tctex-1. Phosphorylation of GEF-H1 Ser885 by PKA or PAK kinases creates an inhibitory 14-3-3-binding site. Here we show a new mode o
Autor:
Maria Jose-Sandi, Mauricio Medrano, Jane Cullis, Ming Tsao, Robert Rottapel, Dedi Meiri, Oliver A. Kent, Daphna Mokady, Anne-Claude Gingras
Publikováno v:
Molecular Cancer Research. 12:B31-B31
Cellular transformation by oncogenic RAS engages the MAPK pathway under strict spatiotemporal regulation by the scaffold protein KSR-1. Here, we find using a whole genome functional shRNA-based screen, that the guanine nucleotide exchange factor GEF-
Publikováno v:
International journal of medical microbiology : IJMM. 295(6-7)
Extraintestinal pathogenic Escherichia coli strains (ExPEC) are the cause of a diverse spectrum of invasive human and animal infections, often leading to septicemia. This review deals with the virulence genes of septicemic ExPEC strains. We discuss t