UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition

Autor: Teresa Ezponda, Daphné Dupéré-Richer, Christine M. Will, Eliza C. Small, Nobish Varghese, Tej Patel, Behnam Nabet, Relja Popovic, Jon Oyer, Marinka Bulic, Yupeng Zheng, Xiaoxiao Huang, Mrinal Y. Shah, Sayantan Maji, Alberto Riva, Manuela Occhionorelli, Giovanni Tonon, Neil Kelleher, Jonathan Keats, Jonathan D. Licht

Publikováno v: Cell Reports, Vol 21, Iss 3, Pp 628-640 (2017)

Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX leads to deactivation of gene expression ultimately promoting the prol

Externí odkaz: https://doaj.org/article/c8e4f4dce46b4e28975494365da80fbf

Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias

Autor: Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M. Meyers, Jordan G. Bryan, Neekesh V. Dharia, Paul J. Hengeveld, Johanna B. Brüggenthies, Huihui Tang, Andrew J. Aguirre, Quinlan L. Sievers, Benjamin L. Ebert, Brian J. Glassner, Christopher J. Ott, James E. Bradner, Nicholas P. Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J. Keats, Richard W. J. Groen, Nathanael S. Gray, Aedin C. Culhane, James M. McFarland, Joshua M. Dempster, Jonathan D. Licht, Lawrence H. Boise, William C. Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S. Mitsiades

Publikováno v: de Matos Simoes, R, Shirasaki, R, Downey-Kopyscinski, S L, Matthews, G M, Barwick, B G, Gupta, V A, Dupéré-Richer, D, Yamano, S, Hu, Y, Sheffer, M, Dhimolea, E, Dashevsky, O, Gandolfi, S, Ishiguro, K, Meyers, R M, Bryan, J G, Dharia, N V, Hengeveld, P J, Brüggenthies, J B, Tang, H, Aguirre, A J, Sievers, Q L, Ebert, B L, Glassner, B J, Ott, C J, Bradner, J E, Kwiatkowski, N P, Auclair, D, Levy, J, Keats, J J, Groen, R W J, Gray, N S, Culhane, A C, McFarland, J M, Dempster, J M, Licht, J D, Boise, L H, Hahn, W C, Vazquez, F, Tsherniak, A & Mitsiades, C S 2023, ' Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias ', Nature Cancer, vol. 4, no. 5, pp. 754-773 . https://doi.org/10.1038/s43018-023-00550-x
Nature Cancer, 4(5), 754-773. Nature Research

Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c38520e5128234e34753590416d0e64
https://doi.org/10.1038/s43018-023-00550-x

Data from Acquired Resistance to EZH2 Inhibitor GSK343 Promotes the Differentiation of Human DLBCL Cell Lines toward an ABC-Like Phenotype

Autor: Wilson H. Miller, Jonathan D. Licht, Sonia V. del Rincón, Koren K. Mann, Nathalie A. Johnson, Ryan N. Rys, Mena Kinal, Alberto Riva, Madelyn Jean Abraham, Daphné Dupéré-Richer, Filippa Pettersson, Audrey Emond, Samuel E.J. Preston

Diffuse large B-cell lymphoma (DLBCL) accounts for 40% of non-Hodgkin lymphoma, and 30% to 40% of patients will succumb to relapsed/refractory disease (rrDLBCL). Patients with rrDLBCL generally have low long-term survival rates due to a lack of effic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e31b9732a90a20cb2c987e58616837
https://doi.org/10.1158/1535-7163.c.6543439

Supplementary Data from DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Autor: Olga A. Guryanova, Jonathan E. Bird, Jonathan D. Licht, Philipp B. Staber, Stefan Kubicek, Sumita Bhaduri-McIntosh, Brian K. Law, Rene Opavsky, Christopher R. Cogle, Alberto Riva, Santhi Pondugula, Richard L. Bennett, Daphné Dupéré-Richer, Jianping Li, Chamara Gunaratne, Luisa M. Posada, Heidi L. Casellas Román, Zachary Zaroogian, Christina Taragjini, Kathryn I. Krajcik, Prabhjot Kaur, Cassandra M. Berntsen, Daniil E. Shabashvili, Huanzhou Xu, Pawel Nowialis, Yang Feng, Kartika Venugopal

Supplementary Data from DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38310290f5d0c23986c2df44818d2da9
https://doi.org/10.1158/1078-0432.22483976

DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Autor: Jonathan D. Licht, Daphné Dupéré-Richer, Huanzhou Xu, Kartika Venugopal, Yang Feng, Richard L. Bennett, Brian K. Law, Heidi L. Casellas Roman, Luisa M Posada, Alberto Riva, Rene Opavsky, Daniil Shabashvili, Kathryn I. Krajcik, Prabhjot Kaur, Chamara Gunaratne, Pawel Nowialis, Christopher R. Cogle, Zachary Zaroogian, Santhi Pondugula, Jianping Li, Jonathan E. Bird, Christina Taragjini, Philipp B. Staber, Olga A. Guryanova, Sumita Bhaduri-McIntosh, Stefan Kubicek, Cassandra M. Berntsen

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 28(4)

Purpose: In acute myeloid leukemia (AML), recurrent DNA methyltransferase 3A (DNMT3A) mutations are associated with chemoresistance and poor prognosis, especially in advanced-age patients. Gene-expression studies in DNMT3A-mutated cells identified si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f516224dea57cb8a1b957558b4c2bcc6
https://pubmed.ncbi.nlm.nih.gov/34880109