Prospective Prediction of Dapaconazole Clinical Drug–Drug Interactions Using an In Vitro to In Vivo Extrapolation Equation and PBPK Modeling

Autor: Natalícia de Jesus Antunes, Fernanda de Lima Moreira, Karin Kipper, Lewis Couchman, Daniel Temponi Lebre, Atholl Johnston, Gilberto De Nucci

Publikováno v: Pharmaceuticals, Vol 16, Iss 1, p 28 (2022)

This study predicted dapaconazole clinical drug–drug interactions (DDIs) over the main Cytochrome P450 (CYP) isoenzymes using static (in vitro to in vivo extrapolation equation, IVIVE) and dynamic (PBPK model) approaches. The in vitro inhibition of

Externí odkaz: https://doaj.org/article/0ff5ee82dc434723913dbb51699e8b49

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Pharmacokinetics of Dapaconazole, A Novel Antifungal Agent, in Beagle Dogs and Inhibition of Cytochrome P450 Family 51

Autor: Noedi L. de Freitas, Gilberto De Nucci, Julio Alejandro Rojas-Moscoso, Gustavo D. Mendes, Juliana S. Palo, Samuel G. N. e Silva, Tiago Zaminelli, Caroline Honaiser Lescano

Publikováno v: Anti-Infective Agents. 16:15-21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ce61fa9400fe3bfc103dd85bde0a86a
https://doi.org/10.2174/2211352515666171124160816

Comparison of dapaconazole with miconazole in the treatment of Tinea cruris

Autor: Rafael Campos, J.O. Ilha, Tainah Babadópulos, Natalicia J. Antunes, André Alves Moraes Gobbato, Cintia Aparecida Rodrigues Santiago Gobbato, G. De Nucci, Ronilson Agnaldo Moreno

Publikováno v: Journal of the European Academy of Dermatology and Venereology. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8359c777afe4161bf0cf62f3179bb68c
https://doi.org/10.1111/jdv.15116

Prospective Prediction of Dapaconazole Clinical Drug-Drug Interactions Using an In Vitro to In Vivo Extrapolation Equation and PBPK Modeling.

Autor: Antunes NJ; Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-881, SP, Brazil., Moreira FL; Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil., Kipper K; Institute of Chemistry, University of Tartu, 14a Ravila Street, 50411 Tartu, Estonia., Couchman L; Analytical Services International (ASI) Ltd., St George's-University of London, Cranmer Terrace, London SW17 0RE, UK.; Pharmaceutical Sciences Clinical Academic Group, King's College London, London SE1 9NH, UK., Lebre DT; Center for Applied Mass Spectrometry (CEMSA), São Paulo 05508-000, SP, Brazil., Johnston A; Analytical Services International (ASI) Ltd., St George's-University of London, Cranmer Terrace, London SW17 0RE, UK.; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., De Nucci G; Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-881, SP, Brazil.; Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo 05508-000, SP, Brazil.; Faculty of Medicine, São Leopoldo Mandic (SLMANDIC), Campinas 13045-755, SP, Brazil.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Dec 26; Vol. 16 (1). Date of Electronic Publication: 2022 Dec 26.