Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Daohua, Jiang"'
Autor:
Huiwen Chen, Zhanyi Xia, Jie Dong, Bo Huang, Jiangtao Zhang, Feng Zhou, Rui Yan, Yiqiang Shi, Jianke Gong, Juquan Jiang, Zhuo Huang, Daohua Jiang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Voltage-gated sodium (NaV) channels mediate a plethora of electrical activities. NaV channels govern cellular excitability in response to depolarizing stimuli. Inactivation is an intrinsic property of NaV channels that regulates cellular exc
Externí odkaz:
https://doaj.org/article/7302ab6074d247a1ae4ceaaaf495f597
Autor:
Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, o
Externí odkaz:
https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801
Autor:
Yue Li, Tian Yuan, Bo Huang, Feng Zhou, Chao Peng, Xiaojing Li, Yunlong Qiu, Bei Yang, Yan Zhao, Zhuo Huang, Daohua Jiang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
NaV1.6 channel plays a critical role in neuronal excitability. Here, authors present human NaV1.6 structures in apo and 4,9-anhydro-tetrodotoxin bound forms, which reveal molecular mechanisms of NaV1.6 Na+ conductance and inhibition by the blocker.
Externí odkaz:
https://doaj.org/article/44b1384fcfcf45fd945dec93fe9afbd0
Autor:
Jiangtao Zhang, Shiqi Liu, Junping Fan, Rui Yan, Bo Huang, Feng Zhou, Tian Yuan, Jianke Gong, Zhuo Huang, Daohua Jiang
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112858- (2023)
Summary: The sodium-activated Slo2.2 channel is abundantly expressed in the brain, playing a critical role in regulating neuronal excitability. The Na+-binding site and the underlying mechanisms of Na+-dependent activation remain unclear. Here, we pr
Externí odkaz:
https://doaj.org/article/c2ad5827a0df472d87f4503b0043fe84
Autor:
Jiangtao Zhang, Yiqiang Shi, Junping Fan, Huiwen Chen, Zhanyi Xia, Bo Huang, Juquan Jiang, Jianke Gong, Zhuo Huang, Daohua Jiang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Voltage-gated sodium channels mediate electrical signaling. Here, authors report the cryo-EM structure of NaVEh from the marine plant Emiliania huxleyi, revealing an unexpected mechanism of N-type fast inactivation.
Externí odkaz:
https://doaj.org/article/140d132d52414319abde02b6ee982e97
Autor:
Xiaojing Li, Feng Xu, Hao Xu, Shuli Zhang, Yiwei Gao, Hongwei Zhang, Yanli Dong, Yanchun Zheng, Bei Yang, Jianyuan Sun, Xuejun Cai Zhang, Yan Zhao, Daohua Jiang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
NaV1.3 is involved in neuronal development, hormone secretion and pain perception. Here, the authors elucidate the molecular mechanism for modulation of NaV1.3 by a site-2 neurotoxin bulleyaconitine A and a subtype selective antagonist ICA121431.
Externí odkaz:
https://doaj.org/article/4638d0c72f164f5d8a96ae7095873380
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Voltage-gated sodium (NaV) channels are responsible for the rapid rising-phase of action potentials in excitable cells. Over 1,000 mutations in NaV channels are associated with human diseases including epilepsy, periodic paralysis, arrhythmias and pa
Externí odkaz:
https://doaj.org/article/05242c432c10442faf1820e3116c36c8
Autor:
Daohua Jiang, Lige Tonggu, Tamer M. Gamal El-Din, Richard Banh, Régis Pomès, Ning Zheng, William A. Catterall
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channels. Here authors reveal the cryo-EM structure of LqhIII bound to NaV1.5 which shows that LqhIII traps the gating charges of the S4 segment in a uniq
Externí odkaz:
https://doaj.org/article/551ce5bc8824402bb013e154205ef0bc
Autor:
Yanli Dong, Yiwei Gao, Shuai Xu, Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Tian Yuan, Bei Yang, Xuejun Cai Zhang, Daohua Jiang, Zhuo Huang, Yan Zhao
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109931- (2021)
Summary: N-type voltage-gated calcium (CaV) channels mediate Ca2+ influx at presynaptic terminals in response to action potentials and play vital roles in synaptogenesis, release of neurotransmitters, and nociceptive transmission. Here, we elucidate
Externí odkaz:
https://doaj.org/article/3f815d9bfcb64a66b3a15ec8b32f971b
Publikováno v:
Nature Structural & Molecular Biology. 29:1208-1216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66161057ba5d0a0e84c6646e8ec9f5c3
https://doi.org/10.1038/s41594-022-00860-1
https://doi.org/10.1038/s41594-022-00860-1