Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Dao‐Fu Dai"'
Autor:
David Carmona-Berrio, Isabel Adarve-Rengifo, Andrea G. Marshall, Zer Vue, Duane D. Hall, Tyne W. Miller-Fleming, Ky’Era V. Actkins, Heather K. Beasley, Paula M. Almonacid, Pierina Barturen-Larrea, Quinn S. Wells, Marcos G. Lopez, Edgar Garza-Lopez, Dao-Fu Dai, Jianqiang Shao, Kit Neikirk, Frederic T. Billings, IV, John A. Curci, Nancy J. Cox, Vivian Gama, Antentor Hinton, Jr., Jose A. Gomez
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110436- (2024)
Summary: Abdominal and thoracic aortic aneurysms (AAAs, TAAs) remain a major cause of deaths worldwide, in part due to the lack of reliable prognostic markers or early warning signs. Sox6 has been found to regulate renin controlling blood pressure. W
Externí odkaz:
https://doaj.org/article/10fbddafdd5e4e57aba0f987d45fef4e
Autor:
Andrea G. Marshall, Kit Neikirk, Zer Vue, Heather K. Beasley, Edgar Garza-Lopez, Larry Vang, Taylor Barongan, Zoe Evans, Amber Crabtree, Elsie Spencer, Josephs Anudokem, Remi Parker, Jamaine Davis, Dominique Stephens, Steven Damo, Thuy T. Pham, Jose A. Gomez, Vernat Exil, Dao-fu Dai, Sandra A. Murray, Mark L. Entman, George E. Taffet, Antentor O. Hinton, Anilkumar K. Reddy
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionMany studies in mice have demonstrated that cardiac-specific innate immune signaling pathways can be reprogrammed to modulate inflammation in response to myocardial injury and improve outcomes. While the echocardiography standard paramete
Externí odkaz:
https://doaj.org/article/7b33348424c54b3a9e0eeab706b78234
Autor:
Nastaran Daneshgar, Mariah R. Leidinger, Stephanie Le, Marco Hefti, Alessandro Prigione, Dao-Fu Dai
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
Neuroinflammation is one of the main mechanisms leading to neuronal death and dysfunction in neurodegenerative diseases. The role of microglia as primary mediators of inflammation is unclear in Leigh syndrome (LS) patients. This study aims to elucida
Externí odkaz:
https://doaj.org/article/dab6a427d3854ac5848e9afe3e7fecc0
Autor:
Nastaran Daneshgar, Andrew W. Baguley, Peir-In Liang, Fei Wu, Yi Chu, Michael T. Kinter, Gloria A. Benavides, Michelle S. Johnson, Victor Darley-Usmar, Jianhua Zhang, Kung-Sik Chan, Dao-Fu Dai
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Daneshgar et al. investigated the role of mitochondrial dysfunction in ADPKD and mitochondria protective agents as potential therapeutics. The authors reported decreased mitochondrial complex activity and downregulation of mitochondrial and metabolic
Externí odkaz:
https://doaj.org/article/1d0d0cfe52ff48c79a03d8870143777f
Autor:
Jin‐Young Yoon, Nastaran Daneshgar, Yi Chu, Biyi Chen, Marco Hefti, Ajit Vikram, Kaikobad Irani, Long‐Sheng Song, Charles Brenner, E. Dale Abel, Barry London, Dao‐Fu Dai
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Background Mice with deletion of complex I subunit Ndufs4 develop mitochondrial encephalomyopathy resembling Leigh syndrome (LS). The metabolic derangement and underlying mechanisms of cardio‐encephalomyopathy in LS remains incompletely un
Externí odkaz:
https://doaj.org/article/9fc05873d4fb4a8a92652c0c9b8bc8e0
Mitochondrial Oxidative Stress Mediates Bradyarrhythmia in Leigh Syndrome Mitochondrial Disease Mice
Publikováno v:
Antioxidants, Vol 12, Iss 5, p 1001 (2023)
Mitochondrial oxidative stress has been implicated in aging and several cardiovascular diseases, including heart failure and cardiomyopathy, ventricular tachycardia, and atrial fibrillation. The role of mitochondrial oxidative stress in bradyarrhythm
Externí odkaz:
https://doaj.org/article/8e4b40a50edc4900ac77f531c508131f
Autor:
Nastaran Daneshgar, Peir-In Liang, Christina J. Michels, Carla M. Nester, Lyndsay A. Harshman, Dao-Fu Dai
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Coronavirus disease 2019 (COVID-19) may cause a wide spectrum of kidney pathologies. The impact of COVID-19 is unclear in the context of the complement system abnormalities, including C3 glomerulopathy (C3G). In this report, we describe a young adult
Externí odkaz:
https://doaj.org/article/79a9c6c77aff45cb8f91c34968d68770
Autor:
Dingxiao Liu, Qiong Ding, Dao-Fu Dai, Biswajit Padhy, Manasa K. Nayak, Can Li, Madison Purvis, Heng Jin, Chang Shu, Anil K. Chauhan, Chou-Long Huang, Massimo Attanasio
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Loss of function of the lipid kinase diacylglycerol kinase ε (DGKε), encoded by the gene DGKE, causes a form of atypical hemolytic uremic syndrome that is not related to abnormalities of the alternative pathway of the complement, by mechanisms that
Externí odkaz:
https://doaj.org/article/e2727f9ef2284dc1bee239ff707aae6f
Autor:
Adonis Z. Wu, Tzu-Lun Ohn, Ren-Jay Shei, Huei-Fang Wu, Yong-Cyuan Chen, Hsiang-Chun Lee, Dao-Fu Dai, Sheng-Nan Wu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2175 (2021)
Sphingosine-1-phosphate (S1P), is a signaling sphingolipid which acts as a bioactive lipid mediator. We assessed whether S1P had multiplex effects in regulating the large-conductance Ca2+-activated K+ channel (BKCa) in catecholamine-secreting chromaf
Externí odkaz:
https://doaj.org/article/6fd3b6c0ee6544bea2fafb3407fc0fea
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 168 (2021)
Mechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with cell growth. Over the past two decades, studies on the mTOR pathway have revealed that mTOR complex 1 controls life span, he
Externí odkaz:
https://doaj.org/article/f3a64f891bb944719af0257f2e7097dc