Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Danzhou Yang"'
Autor:
Hang Lin, Muhammad Hassan Safdar, Sarah Washburn, Saeed S. Akhand, Jonathan Dickerhoff, Mitchell Ayers, Marvis Monteiro, Luis Solorio, Danzhou Yang, Michael K. Wendt
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Limiting cellular plasticity is of key importance for the therapeutic targeting of metastatic breast cancer (MBC). Fibroblast growth receptor (FGFR) is a critical molecule in cellular plasticity and potent inhibitors of FGFR enzymatic activi
Externí odkaz:
https://doaj.org/article/9627326e652d4cd584f63b914469081f
Publikováno v:
Engineering, Vol 38, Iss , Pp 39-51 (2024)
DNA guanine (G)-quadruplexes (G4s) are unique secondary structures formed by two or more stacked G-tetrads in G-rich DNA sequences. These structures have been found to play a crucial role in highly transcribed genes, especially in cancer-related onco
Externí odkaz:
https://doaj.org/article/758e276aab4243aba79bfbbf79874b32
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
G-quadruplex (G4) has been previously observed to be associated with gene expression. In this study, we performed integrative analysis on G4 multi-omics data from in-silicon prediction and ChIP-seq in human genome. Potential G4 sites were classified
Externí odkaz:
https://doaj.org/article/d8669f55873b46e8ae06a53894025f53
Autor:
Saburo Sakai, Danzhou Yang, Takashi Yasuda, Koichiro Akiyama, Takayoshi Kuga, Akihiro Kano, Fumito Shiraishi, Shota Amekawa, Susumu Ohtsuka, Kazumitsu Nakaguchi, Shyuhei Yamaguchi
Publikováno v:
ACS Omega, Vol 4, Iss 2, Pp 2702-2707 (2019)
Externí odkaz:
https://doaj.org/article/b21fe72b6f61439ebfefec4bb40ff7b3
Publikováno v:
ACS Omega, Vol 4, Iss 2, Pp 2533-2539 (2019)
Externí odkaz:
https://doaj.org/article/d0f45aae6a324a0fa9a72fc688888722
Autor:
Wenting Liu, Yi-Fang Zhong, Liu-Yi Liu, Chu-Tong Shen, Wenjuan Zeng, Fuyi Wang, Danzhou Yang, Zong-Wan Mao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
DNA G-quadruplexes occur in oncologically relevant regions, thus are interesting targets for cancer research and treatment. Here, the authors solved the 1:1 and 4:2 (ligand/DNA) NMR structures of human telomeric DNA in complex with platinum(II)-tripo
Externí odkaz:
https://doaj.org/article/b86abdb8dcab48ffa099caa1ceb4eeee
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10801 (2021)
G-quadruplexes are four-stranded nucleic acid secondary structures of biological significance and have emerged as an attractive drug target. The G4 formed in the MYC promoter (MycG4) is one of the most studied small-molecule targets, and a model syst
Externí odkaz:
https://doaj.org/article/cd63912ba407456588f60159c11a8151
Publikováno v:
Molecules, Vol 26, Iss 14, p 4132 (2021)
This review is dedicated to Professor William A. Denny’s discovery of XR5944 (also known as MLN944). XR5944 is a DNA-targeted agent with exceptionally potent antitumor activity and a novel DNA binding mode, bis-intercalation and major groove bindin
Externí odkaz:
https://doaj.org/article/70d807c57be24335a4d92fdf981591e7
Autor:
Guanhui Wu, Desiree Tillo, Sreejana Ray, Ta-Chau Chang, John S. Schneekloth, Charles Vinson, Danzhou Yang
Publikováno v:
Molecules, Vol 25, Iss 15, p 3465 (2020)
G-quadruplexes (G4) are considered new drug targets for human diseases such as cancer. More than 10,000 G4s have been discovered in human chromatin, posing challenges for assessing the selectivity of a G4-interactive ligand. 3,6-bis(1-Methyl-4-vinylp
Externí odkaz:
https://doaj.org/article/7eb68207c446449ca60c4e9267ad76e0
Autor:
Nanjie Deng, Junchao Xia, Lauren Wickstrom, Clement Lin, Kaibo Wang, Peng He, Yunting Yin, Danzhou Yang
Publikováno v:
Molecules, Vol 24, Iss 8, p 1574 (2019)
The human telomeric G-quadruplex (G4) is an attractive target for developing anticancer drugs. Natural products protoberberine alkaloids are known to bind human telomeric G4 and inhibit telomerase. Among several structurally similar protoberberine al
Externí odkaz:
https://doaj.org/article/f02380f2e7904b1f8c39d92371d38ab5