Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Danyi, Lu"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Puerariae lobatae radix (PLR) is a wildly used herbal medicine. Here we aimed to assess the PLR efficacy against UVB (ultraviolet-B)-induced skin aging and to determine the mechanisms thereof. We found a significant protective effect of PLR (topical
Externí odkaz:
https://doaj.org/article/3d1a42a898694c90a0a963019bea0b49
Autor:
Wenjian Sun, Peng Tang, Ye Liang, Jing Li, Jingyu Feng, Nan Zhang, Danyi Lu, Jufang He, Xi Chen
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110506- (2022)
Summary: For survival, animals encode prominent events in complex environments, which modulates their defense behavior. Here, we design a paradigm that assesses how a mild aversive cue (i.e., mild air puff) interacts with sound-evoked flight behavior
Externí odkaz:
https://doaj.org/article/3a565cb36d114db790e5cafbd717bcdd
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
CYP2B10 is responsible for metabolism and detoxification of many clinical drugs. Here, we aimed to investigate a potential role of Period 2 (PER2) in regulating expression of hepatic CYP2B10. Regulatory effects of PER2 on hepatic expression of CYP2B1
Externí odkaz:
https://doaj.org/article/014a37401264465bb354052a0ed7740f
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Identifying drugs with dosing time-dependent effects (chronoeffects) and understanding the underlying mechanisms would help to improve drug treatment outcome. Here, we aimed to determine chronoeffects of the herbal medicines Puerariae radix (PR) and
Externí odkaz:
https://doaj.org/article/3ec9b33d60ae4cc1ada6cf50cd9ab008
Publikováno v:
Xenobiotica. :1-8
Autor:
Min Chen, Yifei Xiao, Fugui Zhang, Jianhao Du, Li Zhang, Yifang Li, Danyi Lu, Zhigang Wang, Baojian Wu
Publikováno v:
Biochemical pharmacology. 205
Delirium is a common and serious neuropsychiatric syndrome characterized with acute cognitive and attentional deficits, however, the effective therapies are lacking. Here, using mouse models of delirium, we investigated the effects of tangeretin (TAN
Publikováno v:
Xenobiotica. 51:1019-1028
1. Retrorsine (RTS) is a pyrrolizidine alkaloid (distributed in many medicinal plants) that has significant hepatotoxicity. Here, we aimed to determine the daily variations in RTS hepatotoxicity (chronotoxicity) in mice, and to investigate the role o
Autor:
Danyi Lu, Wenli Shi, Chunlei Wu, Zhihao Ding, Zhihui Xia, Lijing Fang, Xian Lin, Meiqing Li, Binghua Chen, Yanyan Li, Hongchang Li, Ximing Shao, Wu Su, Ke Liu
Publikováno v:
Biochemical and Biophysical Research Communications. 547:52-58
Natural products are useful tools for biological mechanism research and drug discovery. Due to the excellent tumor cell growth inhibitory profile and sub-nanomolar potency, Coibamide A (CA), an N-methyl-stabilized depsipeptide isolated from marine cy
Autor:
Wu Su, Lijing Fang, Meiqing Li, Danyi Lu, Ximing Shao, Yulian Cheng, Yimin Zhou, Ke Liu, Chunlei Wu, Hongchang Li, Pengxin Wang, Zhehong Cheng
Publikováno v:
Journal of Medicinal Chemistry. 64:991-1000
Coibamide A (1) is a highly N-methylated cyclodepsipeptide with low nanomolar antiproliferative activities against various cancer cell lines. In previous work, we discovered a simplified analogue, [MeAla3-MeAla6]-coibamide (1a), which exhibited the s
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:398-409
ObjectivesWe aimed to determine the circadian responses of mice to Semen Strychni and to investigate the role of pharmacokinetics in generating chronotoxicity.MethodsTotal extract of Semen Strychni was administered by oral gavage to wild-type (WT) an