Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Dany P, Perocheau"'
Autor:
Julien Baruteau, Sharon C. Cunningham, Berna Seker Yilmaz, Dany P. Perocheau, Simon Eaglestone, Derek Burke, Adrian J. Thrasher, Simon N. Waddington, Leszek Lisowski, Ian E. Alexander, Paul Gissen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 135-146 (2021)
X-linked inherited ornithine transcarbamylase deficiency (OTCD) is the most common disorder affecting the liver-based urea cycle, a pathway enabling detoxification of nitrogen waste and endogenous arginine biosynthesis. Patients develop acute hyperam
Externí odkaz:
https://doaj.org/article/10be24db36dd4d05b36ea1c89d212f01
Autor:
John R. Counsell, Guillaume De Brabandere, Rajvinder Karda, Marc Moore, Antonio Greco, Alysha Bray, Juan Antinao Diaz, Dany P. Perocheau, Ulrike Mock, Simon N. Waddington
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 357-365 (2021)
Lentiviral (LV) vectors based on human immunodeficiency virus type I (HIV-1) package two copies of their single-stranded RNA into vector particles. Normally, this RNA genome is reverse transcribed into a double-stranded DNA provirus that integrates i
Externí odkaz:
https://doaj.org/article/91dfe80765324ae6b172bc6c3bfd05e5
Autor:
Leandro R Soria, Sonam Gurung, Giulia De Sabbata, Dany P Perocheau, Angela De Angelis, Gemma Bruno, Elena Polishchuk, Debora Paris, Paola Cuomo, Andrea Motta, Michael Orford, Youssef Khalil, Simon Eaton, Philippa B Mills, Simon N Waddington, Carmine Settembre, Andrés F Muro, Julien Baruteau, Nicola Brunetti‐Pierri
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-14 (2020)
Abstract Urea cycle disorders (UCD) are inherited defects in clearance of waste nitrogen with high morbidity and mortality. Novel and more effective therapies for UCD are needed. Studies in mice with constitutive activation of autophagy unravelled Be
Externí odkaz:
https://doaj.org/article/19085dda865a4f648e70bb866bfbf0bc
Autor:
Maëlle Lorvellec, Alessandro Filippo Pellegata, Alice Maestri, Chiara Turchetta, Elena Alvarez Mediavilla, Soichi Shibuya, Brendan Jones, Federico Scottoni, Dany P. Perocheau, Andrei Claudiu Cozmescu, Juliette M. Delhove, Daniel Kysh, Asllan Gjinovci, John R. Counsell, Wendy E. Heywood, Kevin Mills, Tristan R. McKay, Paolo De Coppi, Paul Gissen
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101808- (2020)
Summary: Explosion of gene therapy approaches for treating rare monogenic and common liver disorders created an urgent need for disease models able to replicate human liver cellular environment. Available models lack 3D liver structure or are unable
Externí odkaz:
https://doaj.org/article/c043e3e17edd419a9dda615cee1a696f
Autor:
Julien Baruteau, Dany P. Perocheau, Joanna Hanley, Maëlle Lorvellec, Eridan Rocha-Ferreira, Rajvinder Karda, Joanne Ng, Natalie Suff, Juan Antinao Diaz, Ahad A. Rahim, Michael P. Hughes, Blerida Banushi, Helen Prunty, Mariya Hristova, Deborah A. Ridout, Alex Virasami, Simon Heales, Stewen J. Howe, Suzanne M. K. Buckley, Philippa B. Mills, Paul Gissen, Simon N. Waddington
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Patients with mutations in the ASL gene present with argininosuccinic aciduria characterised by hyperammonaemia and cognitive impairment. Here, the authors show that cerebral disease involves neuronal nitrosative/oxidative stress that is not induced
Externí odkaz:
https://doaj.org/article/bccd48b998f7466b8b4e37f6409acdb2
Autor:
Rajvinder Karda, Dany P. Perocheau, Natalie Suff, Joanne Ng, Juliette M. K. M. Delhove, Suzanne M. K. Buckley, Samantha Richards, John R. Counsell, Henrik Hagberg, Mark R. Johnson, Tristan R. McKay, Simon N. Waddington
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Luciferase bioimaging in living animals is increasingly being applied in many fields of biomedical research. Rodent imaging usually involves anaesthetising the animal during data capture, however, the biological consequences of anaesthesia h
Externí odkaz:
https://doaj.org/article/9f6f64e65ad641139897de92958624f7
Autor:
Adrian Westhaus, Marti Cabanes-Creus, Kimberley L. Dilworth, Erhua Zhu, David Salas Gómez, Renina G. Navarro, Anais K. Amaya, Suzanne Scott, Magdalena Kwiatek, Alexandra L. McCorkindale, Tara E. Hayman, Silke Frahm, Dany P. Perocheau, Bang Manh Tran, Elizabeth Vincan, Sharon L. Wong, Shafagh A. Waters, Georgina E. Riddiough, Marcos V. Perini, Laurence O.W. Wilson, Julien Baruteau, Sebastian Diecke, Gloria González-Aseguinolaza, Giorgia Santilli, Adrian J. Thrasher, Ian E. Alexander, Leszek Lisowski
The liver is a prime target for in vivo gene therapies using recombinant adeno-associated viral vectors (rAAV). Multiple clinical trials have been undertaken for this target in the past 15 years, however we are still to see market approval of the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456eba301b4b73f9427328cdc937aa92
http://edoc.mdc-berlin.de/23212/1/23212oa.pdf
http://edoc.mdc-berlin.de/23212/1/23212oa.pdf
Autor:
Sharon C. Cunningham, Julien Baruteau, Derek Burke, Adrian J. Thrasher, Berna Seker Yilmaz, Simon Eaglestone, Paul Gissen, Simon N. Waddington, Ian E. Alexander, Dany P. Perocheau, Leszek Lisowski
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 135-146 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
X-linked inherited ornithine transcarbamylase deficiency (OTCD) is the most common disorder affecting the liver-based urea cycle, a pathway enabling detoxification of nitrogen waste and endogenous arginine biosynthesis. Patients develop acute hyperam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca9fa29acfc880509a028452fbec00b
http://www.sciencedirect.com/science/article/pii/S232905012100142X
http://www.sciencedirect.com/science/article/pii/S232905012100142X
Autor:
Adrian Westhaus, Marti Cabanes-Creus, Kimberley L. Dilworth, Erhua Zhu, David Salas Gómez, Renina G. Navarro, Anais K. Amaya, Suzanne Scott, Magdalena Kwiatek, Alexandra L. McCorkindale, Tara E. Hayman, Silke Frahm, Dany P. Perocheau, Bang Manh Tran, Elizabeth Vincan, Sharon L. Wong, Shafagh A. Waters, Laurence O. W. Wilson, Julien Baruteau, Sebastian Diecke, Gloria González-Aseguinolaza, Giorgia Santilli, Adrian J. Thrasher, Ian E. Alexander, Leszek Lisowski
The liver is a prime target for in vivo gene therapies using recombinant adeno-associated viral vectors (rAAV). Multiple clinical trials have been undertaken for this target in the past 15 years, however we are still to see market approval of the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8acdce92d8cb8bbee102c1127b55a1
https://doi.org/10.1101/2022.09.28.510021
https://doi.org/10.1101/2022.09.28.510021
Autor:
Ulrike Mock, Juan Antinao Diaz, Simon N. Waddington, Dany P. Perocheau, Marc Moore, John R. Counsell, Rajvinder Karda, Antonio Greco, Alysha Bray, Guillaume De Brabandere
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 357-365 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Lentiviral (LV) vectors based on human immunodeficiency virus type I (HIV-1) package two copies of their single-stranded RNA into vector particles. Normally, this RNA genome is reverse transcribed into a double-stranded DNA provirus that integrates i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e910a9a483f9f9766f033b6ed683bb
https://doi.org/10.1016/j.omtm.2020.12.005
https://doi.org/10.1016/j.omtm.2020.12.005