Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Danxin Wang"'
Autor:
Lakshmi Manasa S. Chekka, Marwa Tantawy, Taimour Langaee, Danxin Wang, Rolf Renne, Arlene B. Chapman, John G. Gums, Eric Boerwinkle, Rhonda M. Cooper‐DeHoff, Julie A. Johnson
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 4 (2024)
Background Thiazide diuretics are the second most frequently prescribed class of antihypertensives, but up to 50% of patients with hypertension have minimal antihypertensive response to thiazides. We explored circulating microRNAs (miRNAs) in search
Externí odkaz:
https://doaj.org/article/6ac4f0a85e9d4a2dbff85592725bbc0d
Autor:
Nathan D. Seligson, Xunjie Zhang, Mark C. Zemanek, Jasmine A. Johnson, Zachary VanGundy, Danxin Wang, Mitch A. Phelps, Julianna Roddy, Craig C. Hofmeister, Junan Li, Ming J. Poi
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Introduction: Polymorphisms in genes responsible for the metabolism and transport of tacrolimus have been demonstrated to influence clinical outcomes for patients following allogeneic hematologic stem cell transplant (allo-HSCT). However, the clinica
Externí odkaz:
https://doaj.org/article/74d23d0d6a3644e1ac4dd5f599fa8963
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 6, Pp n/a-n/a (2023)
Abstract UDP‐glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that play important roles in the detoxification of endogenous and exogenous substrates. The 22 human UGTs belong to four families (UGT1, UGT2, UGT3, and UGT8) and d
Externí odkaz:
https://doaj.org/article/b7e1806d977a4c29aed3ad57c9b6d818
Autor:
Joseph M. Collins, Adaeze C. Nworu, Somayya J. Mohammad, Liang Li, Chengcheng Li, Chuanjiang Li, Ethan Schwendeman, Mattew Cefalu, Mahmoud Abdel‐Rasoul, Jessie W. Sun, Sakima A. Smith, Danxin Wang
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 11, Pp 2720-2731 (2022)
Abstract The cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigat
Externí odkaz:
https://doaj.org/article/5d55e8a7d4bc4d709515918da4fc7d27
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
CYP2D6 is one of the most polymorphic drug-metabolizing enzymes in the liver. While genetic CYP2D6 variants serve as clinical biomarkers to predict CYP2D6 activity, large inter-person variability in CYP2D6 expression remains unaccounted for. Previous
Externí odkaz:
https://doaj.org/article/106ce48ef9114f248d56934fc3334d82
Autor:
Sophia Sheikh, Carmen Smotherman, Monika Patel, Taimour Langaee, Danxin Wang, Edward Swaray, Esteban Velasquez, Siegfried O.F. Schmidt, Phyllis Hendry, Larisa H. Cavallari, Roger B. Fillingim
Publikováno v:
PAIN Reports, Vol 7, Iss 6, p e1046 (2022)
Abstract. Introduction:. Many patients with chronic pain use prescription opioids. Epigenetic modification of the μ-opioid receptor 1 (OPRM1) gene, which codes for the target protein of opioids, may influence vulnerability to opioid abuse and respon
Externí odkaz:
https://doaj.org/article/20f24e34d837485b9d5afb0febc53ac6
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cytochrome P450 (CYP) drug metabolizing enzymes are responsible for the metabolism of over 70% of currently used medications with the CYP3A family being the most important CYP enzymes in the liver. Large inter-person variability in expression/activit
Externí odkaz:
https://doaj.org/article/91ba945ccbae4a00a11c0758c7d29214
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3061 (2022)
CYP3A4, CYP3A5, and CYP3A7, which are located in a multigene locus (CYP3A), play crucial roles in drug metabolism. To understand the highly variable hepatic expression of CYP3As, regulatory network analyses have focused on transcription factors (TFs)
Externí odkaz:
https://doaj.org/article/6e118bd529ef422a9563721d21d42c50
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1461 (2021)
The estrogen receptor alpha (ESR1) is an important gene transcriptional regulator, known to mediate the effects of estrogen. Canonically, ESR1 is activated by its ligand estrogen. However, the role of unliganded ESR1 in transcriptional regulation has
Externí odkaz:
https://doaj.org/article/2b07c8bf3a7340518a117bcc6d5d040f
Autor:
Julia K Pinsonneault, John T Frater, Benjamin Kompa, Roshan Mascarenhas, Danxin Wang, Wolfgang Sadee
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179020 (2017)
Genetic variants of ESR1 have been implicated in multiple diseases, including behavioral disorders, but causative variants remain uncertain. We have searched for regulatory variants affecting ESR1 expression in human brain, measuring allelic ESR1 mRN
Externí odkaz:
https://doaj.org/article/e1f347956a0b48f38d754b2e3e1456a7