Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Danwei Huangfu"'
Autor:
Bess P. Rosen, Qing V. Li, Hyein S. Cho, Dingyu Liu, Dapeng Yang, Sarah Graff, Jielin Yan, Renhe Luo, Nipun Verma, Jeyaram R. Damodaran, Hanuman T. Kale, Samuel J. Kaplan, Michael A. Beer, Simone Sidoli, Danwei Huangfu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Pluripotent stem cells have remarkable self-renewal capacity: the ability to proliferate indefinitely while maintaining the pluripotent identity essential for their ability to differentiate into almost any cell type in the body. To investiga
Externí odkaz:
https://doaj.org/article/83f39b20ccbe4f7c9720d5859d8c1675
Autor:
Samuel Joseph Kaplan, Wilfred Wong, Jielin Yan, Julian Pulecio, Hyein S. Cho, Qianzi Li, Jiahui Zhao, Jayanti Leslie-Iyer, Jonathan Kazakov, Dylan Murphy, Renhe Luo, Kushal K. Dey, Effie Apostolou, Christina S. Leslie, Danwei Huangfu
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114640- (2024)
Summary: Functional enhancer annotation is critical for understanding tissue-specific transcriptional regulation and prioritizing disease-associated non-coding variants. However, unbiased enhancer discovery in disease-relevant contexts remains challe
Externí odkaz:
https://doaj.org/article/18884ea54402465ca393dbb1bcd2118f
Autor:
Tingxu Chen, Heather Alcorn, Sujan Devbhandari, Dirk Remus, Elizabeth Lacy, Danwei Huangfu, Kathryn V. Anderson
Publikováno v:
Biology Open, Vol 11, Iss 8 (2022)
Formation of a properly sized and patterned embryo during gastrulation requires a well-coordinated interplay between cell proliferation, lineage specification and tissue morphogenesis. Following transient physical or pharmacological manipulations of
Externí odkaz:
https://doaj.org/article/62f5a8c2360040faaffd6dc642e9f2fc
Autor:
Virginia Teijeiro, Dapeng Yang, Sonali Majumdar, Federico González, Robert W. Rickert, Chunlong Xu, Richard Koche, Nipun Verma, Eric C. Lai, Danwei Huangfu
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 616-625 (2018)
Summary: MicroRNAs (miRNAs) are the effectors of a conserved gene-silencing system with broad roles in post-transcriptional regulation. Due to functional overlaps, assigning specific functions to individual miRNAs has been challenging. DICER1 cleaves
Externí odkaz:
https://doaj.org/article/d7dd2ff28169429499d9a5efd8d090f0
Autor:
Sadaf Amin, Brandoch Cook, Ting Zhou, Zaniar Ghazizadeh, Raphael Lis, Tuo Zhang, Mona Khalaj, Miguel Crespo, Manuradhi Perera, Jenny Zhaoying Xiang, Zengrong Zhu, Mark Tomishima, Chengyang Liu, Ali Naji, Todd Evans, Danwei Huangfu, Shuibing Chen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes. Here, the authors generate mono-hormonal glucose-responding pancreatic β-like cells in vitro and through a screen identify a drug that rescues pancreatic β-like cell death i
Externí odkaz:
https://doaj.org/article/c14e49f0fd174b1ebce0f8854fb56b94
Autor:
Kihyun Lee, Hyunwoo Cho, Robert W. Rickert, Qing V. Li, Julian Pulecio, Christina S. Leslie, Danwei Huangfu
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 382-393.e7 (2019)
Summary: Transcriptional regulatory mechanisms of lineage priming in embryonic development are largely uncharacterized because of the difficulty of isolating transient progenitor populations. Directed differentiation of human pluripotent stem cells (
Externí odkaz:
https://doaj.org/article/3ae9bdac9b504487a47ec8680a20e805
Publikováno v:
Stem Cell Reports, Vol 4, Iss 6, Pp 1103-1111 (2015)
The development of new gene-editing tools, in particular the CRISPR/Cas system, has greatly facilitated site-specific mutagenesis in human embryonic stem cells (hESCs), including the introduction or correction of patient-specific mutations for diseas
Externí odkaz:
https://doaj.org/article/7eefbed17c1f4feaa9f806e1d4c754bd
Autor:
Federico González, Daniela Georgieva, Fabio Vanoli, Zhong-Dong Shi, Matthias Stadtfeld, Thomas Ludwig, Maria Jasin, Danwei Huangfu
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 651-660 (2013)
Induced pluripotent stem cells (iPSCs) hold great promise for personalized regenerative medicine. However, recent studies show that iPSC lines carry genetic abnormalities, suggesting that reprogramming may be mutagenic. Here, we show that the ectopic
Externí odkaz:
https://doaj.org/article/42225dc0d06f426aa70d80c381455699
Publikováno v:
PLoS Biology, Vol 5, Iss 9 (2007)
Externí odkaz:
https://doaj.org/article/30af75b9330b48d58cb13476d13c6ed4
Publikováno v:
PLoS Biology, Vol 5, Iss 7, p e163 (2007)
In healthy adult mice, the beta cell population is not maintained by stem cells but instead by the replication of differentiated beta cells. It is not known, however, whether all beta cells contribute equally to growth and maintenance, as it may be t
Externí odkaz:
https://doaj.org/article/68cb139a87f0472da4d4962efaeb2091