Mapping of Brain Activity in the Analgesia Induced by Phα1β and Morphine

Autor: Danuza Montijo Diniz, Carlos Malamut, Marina Rios Araújo, Andrea Vidal Ferreira, Juliana Figueira Silva, Marta do Nascimento Cordeiro, Marcia Helena Borges, Marco Aurélio Romano Silva, Marcus Vinicius Gomez, Célio Jose Castro Junior

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2022)

Preclinical evidence suggests the potential of Phα1β, a toxin obtained from the venom of spider Phoneutria nigriventer, as a new analgesic drug. Molecular brain imaging techniques have afforded exciting opportunities to examine brain processes in c

Externí odkaz: https://doaj.org/article/0614b94e2bae43b0a866d3705e14fef9

The inhibitory effect of Phα1β toxin on diabetic neuropathic pain involves the CXCR4 chemokine receptor

Autor: Célio José de Castro Junior, Cláudio Antônio da Silva Júnior, Juliana Figueira da Silva, Nancy Scardua Binda, Juliano Ferreira, Marcus Vinicius Gomez, Danuza Montijo Diniz, Flavia Viana Santa Cecilia, Marta N. Cordeiro, Elizete Maria Rita Pereira

Publikováno v: Pharmacological Reports. 72:47-54

Diabetic neuropathy is a common cause of painful diabetic neuropathy (PDN). C-X-C chemokine receptor type 4 (CXCR4) expression is increased in peripheral nerve samples from diabetes patients, suggesting a role for CXCR4 in PDN. Therefore, we evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdda0c2ef5c55ef2fa6bd9e3c556a0e1
https://doi.org/10.1007/s43440-019-00002-3

Analgesic and side effects of intravenous recombinant Phα1β

Autor: Ricardo Andrez Machado de Ávila, Gabriela Trevisan, Elizete Maria Rita Pereira, Marco Aurélio Romano Silva, Duana Carvalho dos Santos, Vanessa Araujo Borges, Marcus Vinicius Gomez, Flávia Karine Rigo, Mateus Rossato, Juliano Ferreira, Juliana Figueira da Silva, Danuza Montijo Diniz, Célio J. Castro, Thiago M. Cunha

Publikováno v: The Journal of Venomous Animals and Toxins Including Tropical Diseases
Journal of Venomous Animals and Toxins including Tropical Diseases v.26 2020
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 26 (2020)
Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 26, Article number: e20190070, Published: 17 APR 2020

Background: Intrathecal injection of voltage-sensitive calcium channel blocker peptide toxins exerts analgesic effect in several animal models of pain. Upon intrathecal administration, recombinant Phα1β exerts the same analgesic effects as the thos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869a1f177548fa5b257ad69dc3e27e51
https://pubmed.ncbi.nlm.nih.gov/32362927

Protective effect of a spider recombinant toxin in a murine model of Huntington's disease

Autor: Cristina Guatimosim, Thatiane C.G. Machado, Danuza Montijo Diniz, Marina Ladeira, Marcus Vinicius Gomez, Julliane V. Joviano-Santos, Kivia B. Soares, André R. Massensini, Lorena F. Fernandes, Aline Silva de Miranda, Priscila Aparecida Costa Valadão, Matheus P.S. Magalhães-Gomes

Publikováno v: Neuropeptides. 85:102111

Abnormal calcium influx and glutamatergic excitotoxicity have been extensively associated with neuronal death in Huntington's disease (HD), a genetic movement disorder. Currently, there is no effective treatment for this fatal condition. The neurotox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb0393f0cc659c547a7ce9057057bae
https://doi.org/10.1016/j.npep.2020.102111

Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-Like Model

Autor: Danuza Montijo Diniz, Nancy Scardua Binda, Caroline P. Klein, Marcus Vinicius Gomez, Marcos Rodrigues Cintra, Alessandra Hubner de Souza, André Arigony Souto

Publikováno v: Pain Research and Treatment, Vol 2016 (2016)
Pain Research and Treatment
Repositório Institucional PUCRS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS

The mechanism underlying pain symptoms in fibromyalgia (FM) is not fully understood. Oxidative stress has emerged as pathophysiological event occurring during the development of the disease. The present study aimed at investigating the efficacy of re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e29c65cad5a2a9c0b86b0feb8385108
https://doaj.org/article/a6ce9a84bedd4322bc166787bde7a2a5