Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Danuta Marona-Lewicka"'
Publikováno v:
Neuropharmacology. 83:1-8
Chronic administration of lysergic acid diethylamide (LSD) every other day to rats results in a variety of abnormal behaviors. These build over the 90 day course of treatment and can persist at full strength for at least several months after cessatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf44d29d8fd70de3b9282e6b95c3baf
https://doi.org/10.1016/j.neuropharm.2014.03.013
https://doi.org/10.1016/j.neuropharm.2014.03.013
Publikováno v:
Neuropharmacology. 61:503-512
Many people who take LSD experience a second temporal phase of LSD intoxication that is qualitatively different, and was described by Daniel Freedman as "clearly a paranoid state." We have previously shown that the discriminative stimulus effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453776a21419d92daaf2c327cde542c0
https://doi.org/10.1016/j.neuropharm.2011.02.006
https://doi.org/10.1016/j.neuropharm.2011.02.006
Publikováno v:
Psychopharmacology. 203:265-277
Rationale Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. Objective The present study sought to characterize the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecad7720001581138e6885e5ca83930e
https://doi.org/10.1007/s00213-008-1238-0
https://doi.org/10.1007/s00213-008-1238-0
Autor:
Michael R. Braden, Jason C. Parrish, Deborah M. Kurrasch-Orbaugh, Thomas H. McLean, James J. Chambers, David E. Nichols, Danuta Marona-Lewicka
Publikováno v:
Journal of Medicinal Chemistry. 49:4269-4274
A conformationally restricted analogue of mescaline, C-(4,5,6-trimethoxyindan-1-yl)-methanamine, was designed using a 5-HT(2A) receptor homology model. The compound possessed 3-fold higher affinity and potency than and efficacy equal to that of mesca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b721edbef86b9379632fb57c9f1f373
https://doi.org/10.1021/jm060272y
https://doi.org/10.1021/jm060272y
Publikováno v:
Psychopharmacology. 180:427-435
The effect of LSD in humans has been described as occurring in two temporal phases. The behavioral effects in rats also occur in two temporal phases: an initial suppression of exploration followed by increased locomotor activity. We decided to invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6304fe76bac8b67ef2682305c847050d
https://doi.org/10.1007/s00213-005-2183-9
https://doi.org/10.1007/s00213-005-2183-9
Publikováno v:
Psychopharmacology. 172:415-421
Aripiprazole (OPC-14597) is a novel atypical antipsychotic drug with a low incidence of side effects. The therapeutic action of aripiprazole has been attributed to its unique agonist/antagonist effects at D(2) dopamine receptors; however, aripiprazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99990a59a65389a6bf8157c8944e25a3
https://doi.org/10.1007/s00213-003-1677-6
https://doi.org/10.1007/s00213-003-1677-6
Autor:
Deborah M. Kurrasch-Orbaugh, Niels H. Jensen, Danuta Marona-Lewicka, James J. Chambers, Jason C. Parrish, David E. Nichols
Publikováno v:
Journal of Medicinal Chemistry. 46:3526-3535
In studies of the SAR of phenethylamine-type serotonin 5-HT(2A) receptor agonists, substituted conformationally constrained tetrahydronaphthofurans were designed to investigate the optimal conformation of the 2-aminoethyl moiety. These compounds were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0136c8c73e9666727c9a950a3d12b377
https://doi.org/10.1021/jm030064v
https://doi.org/10.1021/jm030064v
Autor:
Deborah M. Kurrasch-Orbaugh, Medhane G. Cumbay, Danuta Marona-Lewicka, Jennifer Selken, Joshua G. Lisnicchia, David E. Nichols
Publikováno v:
Psychopharmacology. 164:93-107
Rationale. There is substantial evidence that lisuride can produce effects linked to 5-HT1A receptor occupancy. Nevertheless, this action has generally been ignored in the mechanism of action of lisuride, in favor of an exclusive role for dopamine re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8f64e76c2d6273eccb3b9caf7db29a
https://doi.org/10.1007/s00213-002-1141-z
https://doi.org/10.1007/s00213-002-1141-z
Publikováno v:
Journal of Medicinal Chemistry. 45:4344-4349
Lysergic acid amides were prepared from (R,R)-(-)-, (S,S)-(+)-, and cis-2,4-dimethyl azetidine. The dimethylazetidine moiety is considered here to be a rigid analogue of diethylamine, and thus, the target compounds are all conformationally constraine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51adceb7b30de983df83522944de607f
https://doi.org/10.1021/jm020153s
https://doi.org/10.1021/jm020153s
Autor:
Danuta Marona-Lewicka, Deborah M. Kurrasch-Orbaugh, and Amjad M. Qandil, Madina Gerasimov, David E. Nichols
Publikováno v:
Journal of Medicinal Chemistry. 42:4257-4263
The enantiomers of 3-(N-methylpyrrolidin-2-ylmethyl)-5-methoxyindole, 1, and 3-(N-methylpyrrolidin-2-ylmethyl)-4-hydoxyindole, 3, were prepared using an asymmetric synthesis that employed (+)- or (-)-proline. A new approach was developed that had cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5590e544b99e13d7325eaf91636b762e
https://doi.org/10.1021/jm990325u
https://doi.org/10.1021/jm990325u