Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Danuta Lubicka"'
Autor:
Sameer C. Dhamne, Meera E. Modi, Audrey Gray, Simone Bonazzi, Lucas Craig, Elizabeth Bainbridge, Lahin Lalani, Chloe E. Super, Samantha Schaeffer, Ketthsy Capre, Danuta Lubicka, Guiqing Liang, Doug Burdette, Stephanie M. McTighe, Sarika Gurnani, Sheryl Anne D. Vermudez, Daniel Curtis, Christopher J. Wilson, Mustafa Q. Hameed, Angelica D'Amore, Alexander Rotenberg, Mustafa Sahin
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 10, Pp 1790-1801 (2023)
Abstract Objective Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder caused by autosomal‐dominant pathogenic variants in either the TSC1 or TSC2 gene, and it is characterized by hamartomas in multiple organs, such as skin, kidney, l
Externí odkaz:
https://doaj.org/article/5e6e60c1d4644ed1b4ab20f434f5f54a
Autor:
Cheryl Carson, Pichai Raman, Jennifer Tullai, Lei Xu, Martin Henault, Emily Thomas, Sarita Yeola, Jianmin Lao, Mark McPate, J Martin Verkuyl, George Marsh, Jason Sarber, Adam Amaral, Scott Bailey, Danuta Lubicka, Helen Pham, Nicolette Miranda, Jian Ding, Hai-Ming Tang, Haisong Ju, Pamela Tranter, Nan Ji, Philipp Krastel, Rishi K Jain, Andrew M Schumacher, Joseph J Loureiro, Elizabeth George, Giuliano Berellini, Nathan T Ross, Simon M Bushell, Gül Erdemli, Jonathan M Solomon
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127498 (2015)
Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell profiling experiment (CLiP) of englerin A on ¬over 500 well characterized cancer cell lines
Externí odkaz:
https://doaj.org/article/3ef63ce23a0f45a2b040999806a93624
Autor:
Margaret E Brousseau, Kevin B Clairmont, Glen Spraggon, Alec N Flyer, Andrei A Golosov, Philipp Grosche, Jérôme André, Shari Caplan, Guanjing Chen, Li Fan, Raphael Gattlen, Alexander Koch, Ian Lewis, Jingzhou Li, Eugene Liu, Danuta Lubicka, Andreas Marzinzik, Katsumasa Nakajima, David Nettleton, Johannes Ottl, Meihui Pan, Tajesh Patel, Stephanie Pickett, Jennifer Poirier, Patrick C Reid, Xavier Pelle, Vanitha Subramanian, Victoria Vera, Mei Xu, Lihua Yang, Qing Yang, jinghua yu, Guoming Zhu, Lauren G Monovich
Publikováno v:
Circulation. 144
Elevated LDL-C is a major risk factor for atherosclerotic cardiovascular disease, the leading cause of death worldwide. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has pronounced effects on LDL-C levels via its modulation of hepatic LDL rec
Autor:
Katsumasa Nakajima, David Nettleton, Guoming Zhu, Debra Burdick, Alexander W. Koch, Qing Yang, Glen Spraggon, Margaret E. Brousseau, Guanjing Chen, Lisa Ames, Raphael Gattlen, Flyer Alec, Jennifer Poirier, Jingzhou Li, Mohindra Seepersaud, Dawn Kelly-Sullivan, Stephanie Pickett, Xavier Pelle, Lauren Perry, Raj Chopra, Jakal Amin, Jerome Andre, Danuta Lubicka, Victoria Vera, Philipp Grosche, Patel Tajesh Jayprakash, Ian Lewis, Lihua Yang, Eugene Liu, Andrei Golosov, jinghua yu, Li Fan, Patrick C. Reid, Lauren G. Monovich, Shari L. Caplan, Meihui Pan, Diana Dubiel, Vanitha Subramanian, Kevin B. Clairmont, Johannes Ottl, Mei Xu, Andreas Marzinzik
Publikováno v:
Cell Chemical Biology. 29:249-258.e5
Summary Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-
Autor:
Noel Marie-France Thomsen, Simone Bonazzi, Stephanie M. McTighe, Guiqing Liang, Danuta Lubicka, Sarah Salas, Jill Nunez, Franco Lombardo, Rajeshri Ganesh Karki, Audrey Gray, Stefan Peukert, Doug Burdette, Jean-Cosme Dodart, Leon Murphy, Grazia Piizzi, Carleton Goold, Labbe-Giguere Nancy, Erin P. Keaney, Jonathan D. Biag, Christine D. Wilson, Aakruti Gorde, Lawrence G. Hamann, Yingchuan Sun, Lin Deng, Hasnain A. Malik, Daniel Curtis, Shanming Liu
Publikováno v:
Journal of medicinal chemistry. 63(3)
Recent clinical evaluation of everolimus for seizure reduction in patients with tuberous sclerosis complex (TSC), a disease with overactivated mechanistic target of rapamycin (mTOR) signaling, has demonstrated the therapeutic value of mTOR inhibitors
Autor:
Alessandro Grattoni, Antonia Susnjar, Samuel M. Cadena, Priya Jain, Yasaman Shirazi-Fard, Nicola Di Trani, Jessica Rhudy, Corrine Ying Xuan Chua, Mauro Ferrari, Grit Laue, Danuta Lubicka, Andrea Ballerini, Louis S. Stodieck
Publikováno v:
Advanced Therapeutics. 3:2070014
Autor:
Jessica Rhudy, Samuel M. Cadena, Nicola Di Trani, Antonia Susnjar, Danuta Lubicka, Yasaman Shirazi-Fard, Louis S. Stodieck, Corrine Ying Xuan Chua, Alessandro Grattoni, Andrea Ballerini, Grit Laue, Mauro Ferrari, Priya Jain
Publikováno v:
Advanced Therapeutics. 3:2000014
Autor:
Burks Heather Elizabeth, Noel Marie-France Thomsen, Alexander Fekete, Alice Loo, Christina A. Kirby, Lawrence G. Hamann, Yingchuan Sun, Chunrong Wang, Jianling Wang, Chitra Saran, Danuta Lubicka, Donald P. McDonnell, Yuji Mishina, Franco Lombardo, Jason Baird, Tinya Abrams, Kaitlin J. Macchi, Stefan Peukert, Jill Nunez, John D. Norris, Sunkyu Kim
Publikováno v:
Journal of medicinal chemistry. 60(7)
Tetrahydroisoquinoline 40 has been identified as a potent ERα antagonist and selective estrogen receptor degrader (SERD), exhibiting good oral bioavailability, antitumor efficacy, and SERD activity in vivo. We outline the discovery and chemical opti
Autor:
Jian Ding, Martin Henault, Nicolette Miranda, Nathan T. Ross, Scott Bailey, Rishi K. Jain, Hai-Ming Tang, Lei Xu, Danuta Lubicka, Jonathan M Solomon, Jason Sarber, Mark McPate, Helen Trinh Pham, J. Martin Verkuyl, Bushell Simon, Haisong Ju, Adam Amaral, Gul Erdemli, Jennifer Tullai, Andrew M. Schumacher, Pichai Raman, Pamela Tranter, Jianmin Lao, Giuliano Berellini, Elizabeth George, Sarita Yeola, Philipp Krastel, Joseph Loureiro, Emily Thomas, George Marsh, Cheryl Carson, Nan Ji
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127498 (2015)
PLoS ONE
PLoS ONE
Englerin A is a structurally unique natural product reported to selectively inhibit growth of renal cell carcinoma cell lines. A large scale phenotypic cell profiling experiment (CLiP) of englerin A on ¬over 500 well characterized cancer cell lines