Výsledky vyhledávání - "Danuta Florczyk"

Identification of an intracellular M17 family leucine aminopeptidase that is required for virulence in Staphylococcus aureus

Autor: Danuta Florczyk, Joanna Koziel, Jan Potempa, Jessica E. Davenport, Andrej Tarkowski, Tiffany M. Robison, Frances E. Rivera, Lindsey N. Shaw, Ing-Marie Jonsson, Ronan K. Carroll

Publikováno v: Microbes and Infection. 14:989-999

Staphylococcus aureus is a highly virulent bacterial pathogen capable of causing a variety of ailments throughout the human body. It is a major public health concern due to the continued emergence of highly pathogenic methicillin resistant strains (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21e3f19d2d6bdeb08437bd6c7a446b2
https://doi.org/10.1016/j.micinf.2012.04.013

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Differential Regulation by Toll-Like Receptor Agonists Reveals That MCPIP1 Is the Potent Regulator of Innate Immunity in Bacterial and Viral Infections

Autor: Danuta Florczyk, E. Blazusiak, Jan Potempa, Jolanta Jura, Joanna Koziel

Publikováno v: Journal of Innate Immunity. 5:15-23

Toll-like receptors (TLRs) are key molecules in innate immunity that recognize a variety of pathogen-associated molecular patterns. Activation of TLRs by their agonists initiates several signaling cascades, which eventually result in the expression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::668bd71f413ad7173df87c4bf809b0a9
https://doi.org/10.1159/000339826

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Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence

Autor: Jan Potempa, Karolina Plaza, Jan J. Enghild, Stephen C. Pak, Tomasz Kantyka, Ida B. Thøgersen, Gary A. Silverman, Hennig R. Stennicke, Joanna Koziel, Danuta Florczyk

Publikováno v: Kantyka, T, Plaza, K, Koziel, J, Florczyk, D, Stennicke, H R, Thøgersen, I, Enghild, J J, Silverman, G A, Pak, S C & Potempa, J 2011, ' Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence ', Journal of Applied Biological Chemistry, vol. 392, no. 5, pp. 483-9 . https://doi.org/10.1515/BC.2011.044

Bacterial proteases are considered virulence factors and it is presumed that by abrogating their activity, host endogenous protease inhibitors play a role in host defense against invading pathogens. Here we present data showing thatStaphylococcus aur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c972283d95794274311531a68c6f3db2
https://europepmc.org/articles/PMC4372843/