IL-10 modified mRNA monotherapy prolongs survival after composite facial allografting through the induction of mixed chimerism

Autor: Ana Elena Aviña, Dante De Paz, Shu-Chun Huang, Kuan-Hung Chen, Yun-Ching Chang, Chin-Ming Lee, Chia-Hsien Lin, Fu-Chan Wei, Aline Yen Ling Wang

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 610-627 (2023)

Vascularized composite allotransplantation has great potential in face transplantation by supporting functional restoration following tissue grafting. However, the need for lifelong administration of immunosuppressive drugs still limits its wide use.

Externí odkaz: https://doaj.org/article/3a1c7d4fa6dd4275be4742c33687b373

The Mandible Ameliorates Facial Allograft Rejection and Is Associated with the Development of Regulatory T Cells and Mixed Chimerism

Autor: Chin-Ming Lee, Ana Elena Aviña, Dante De Paz, Chia-Hsien Lin, Esteban Cardona, Fu-Chan Wei, Cheng-Hung Lin, Aline Yen Ling Wang

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 11104, p 11104 (2021)

Vascularized composite allografts contain various tissue components and possess relative antigenicity, eliciting different degrees of alloimmune responses. To investigate the strategies for achieving facial allograft tolerance, we established a mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488356b69ce22f0aa1a2f0ff0e56caeb
https://pubmed.ncbi.nlm.nih.gov/34681764

Prognostic impact of extratumoral perineural invasion in patients with oral cavity squamous cell carcinoma

Autor: Ching Hua Yeh, Li-Ang Lee, Chia-Hsun Hsieh, Chien-Yu Lin, Dante De Paz, Chung-Jan Kang, Hung-Ming Wang, Chun-Ta Liao, Kang-Hsing Fan, Li-Yu Lee, Tzu-Chen Yen

Publikováno v: Cancer Medicine
Cancer Medicine, Vol 8, Iss 14, Pp 6185-6194 (2019)

Purpose Perineural invasion (PNI) is an adverse prognostic factor in patients with oral cavity squamous cell carcinoma (OCSCC). The American Joint Committee on Cancer Staging Manual, eighth edition, introduced a subdivision of PNI into two distinct f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad58877f853b8a004e66d88f88f413a
https://pubmed.ncbi.nlm.nih.gov/31290283

Prognostic Stratification of Patients With Advanced Oral Cavity Squamous Cell Carcinoma

Autor: Kai-Ping Chang, Dante De Paz, Huang-Kai Kao, Yenlin Huang

Publikováno v: Current Oncology Reports. 19

Prognosis of advanced oral squamous cell carcinoma remains a challenge for clinicians despite progress in its diagnosis and treatment over the past decades. In this review, we assessed clinicopathological factors and potential biomarkers along with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac62afff9a7930a7d74218f53a7fbcd1
https://doi.org/10.1007/s11912-017-0624-3