Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dante A. Maugeri"'
Autor:
Juan José Cazzulo, Christopher Olaya, Edward L. D'Antonio, Julian Sherman, Dante A. Maugeri, Jonathan J. Mills, Soledad Natalia Gonzalez, Joshua G. Pierce, Breana L. Laguera, Ana Rodriguez, Jeffrey R. Enders
Publikováno v:
Bioorganicmedicinal chemistry letters. 32
Ribose 5-phosphate isomerase type B (RPI-B) is a key enzyme of the pentose phosphate pathway that catalyzes the isomerization of ribose 5-phosphate (R5P) and ribulose 5-phosphate (Ru5P). Trypanosoma cruzi RPI-B (TcRPI-B) appears to be a suitable drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237f97446d64aedd9eafdea4f2ebfdc2
https://pubmed.ncbi.nlm.nih.gov/33249135
https://pubmed.ncbi.nlm.nih.gov/33249135
Autor:
Juan José Cazzulo, José M. Delfino, W.M. Valsecchi, Dante A. Maugeri, Soledad Natalia Gonzalez
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE, Vol 12, Iss 2, p e0172405 (2017)
PLoS ONE
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE, Vol 12, Iss 2, p e0172405 (2017)
PLoS ONE
The enzyme of the pentose phosphate pathway (PPP) ribulose-5-phosphate-epimerase (RPE) is encoded by two genes present in the genome of Trypanosoma cruzi CL Brener clone: TcRPE1 and TcRPE2. Despite high sequence similarity at the amino acid residue l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b0d7e63c1c678788fddb8fcf3013dd
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172405
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172405
Autor:
Dante A. Maugeri, Frederik Opperdoes, Alejandro Aranda, Cristina Nowicki, Juan José Cazzulo, Antonio D. Uttaro
Publikováno v:
International Journal for Parasitology. 36:295-307
Trypanosoma brucei procyclic forms possess three different malate dehydrogenase isozymes that could be separated by hydrophobic interaction chromatography and were recognized as the mitochondrial, glycosomal and cytosolic malate dehydrogenase isozyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c8c9d7ea5159752875abf154be84ad
https://doi.org/10.1016/j.ijpara.2005.09.013
https://doi.org/10.1016/j.ijpara.2005.09.013
Autor:
Dante A. Maugeri, Juan J. Cazzulo
Publikováno v:
FEMS Microbiology Letters. 234:117-123
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d385ba4fe9e4f40c0d14d9d08f1ae6c
https://doi.org/10.1111/j.1574-6968.2004.tb09522.x
https://doi.org/10.1111/j.1574-6968.2004.tb09522.x
Autor:
Michael P. Barrett, Richard Burchmore, Dante A. Maugeri, Juan José Cazzulo, Patrick O.J. Ogbunude
Publikováno v:
Molecular and Biochemical Parasitology. 130:117-125
The metabolism of pentose phosphates was studied in Leishmania mexicana promastigotes. Each of the enzymes of the classical pentose phosphate pathway (PPP) has been identified and specific activities measured. Functioning of the PPP was demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9934ce9a9ef7474c6de67b575de32d
https://doi.org/10.1016/s0166-6851(03)00173-7
https://doi.org/10.1016/s0166-6851(03)00173-7
Publikováno v:
Essays in biochemistry. 51
The causative agent of Chagas disease, Trypanosoma cruzi, metabolizes glucose through two major pathways: glycolysis and the pentose phosphate pathway. Glucose is taken up via one facilitated transporter and its catabolism by the glycolytic pathway l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51efc41de7a57925dc6b181c393cd996
https://pubmed.ncbi.nlm.nih.gov/22023439
https://pubmed.ncbi.nlm.nih.gov/22023439
Publikováno v:
FEMS microbiology letters. 314(1)
Comparative studies showed that, like Trypanosoma cruzi, Trypanosoma brucei exhibits functional cytosolic and mitochondrial malic enzymes (MEs), which are specifically linked to NADP. Kinetic studies provided evidence that T. cruzi and T. brucei MEs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9057ec4848179c048e00b02f3f8499bf
https://pubmed.ncbi.nlm.nih.gov/21105905
https://pubmed.ncbi.nlm.nih.gov/21105905
Publikováno v:
Molecular and biochemical parasitology. 177(1)
Trypanosoma cruzi exhibits two putative isocitrate dehydrogenases (IDHs). Both idh genes were cloned and the recombinant enzymes expressed in Escherichia coli. Our results showed that T. cruzi IDHs are strictly dependent on NADP(+) and display appare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4692b9610c4a7b7cc6b2adb63c7e8a06
https://pubmed.ncbi.nlm.nih.gov/21291916
https://pubmed.ncbi.nlm.nih.gov/21291916
Autor:
Gabriela García, Rosario Duran, Monica Galleano, Dante A. Maugeri, Patricia Andrea Garavaglia, Andrés M. Ruiz, Joaquín J.B. Cannata
Publikováno v:
Molecular and biochemical parasitology. 173(2)
Drugs currently used for treatment of Trypanosoma cruzi infection, the ethiological agent of Chagas’ disease, have shown side effects and variable efficiency. With the aim to describe parasite enzymes involved in the mechanisms of action of trypano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812b26e9a7e379a83af273076ddf1f40
https://pubmed.ncbi.nlm.nih.gov/20595031
https://pubmed.ncbi.nlm.nih.gov/20595031
Publikováno v:
Molecular and biochemical parasitology. 166(2)
As part of a study on aminotransferases, genes coding for putative enzymes from Trypanosoma brucei and Leishmania major (alanine aminotransferases: ALATs, Tb927.1.3950 and LmjF12.0630; kynurenine aminotransferase: KAT, Tb10.389.1810; and tyrosine ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ecf61564e4fff913a9f0c2f74b6481
https://pubmed.ncbi.nlm.nih.gov/19443056
https://pubmed.ncbi.nlm.nih.gov/19443056