Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Danrong Li"'
Rhein Derivative 4F Inhibits the Malignant Phenotype of Breast Cancer by Downregulating Rac1 Protein
Autor:
Xinxiao Li, Yunfeng Liu, Yuhua Zhao, Wei Tian, Lina Zhai, Huifeng Pang, Jiankang Kang, Huaxin Hou, Yanhua Chen, Danrong Li
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundTriple-negative breast cancer is a common malignant tumor with unfavorable prognosis affecting women worldwide; thus, there is an urgent need for novel therapeutic drugs with improved anti-tumor activity. Rac family small GTPase 1 (Rac1) pl
Externí odkaz:
https://doaj.org/article/2f9c7128976d47ae9b96609c8273d3a3
Autor:
Honglan Zhai, Chunmiao Wang, Junying Li, Dandan Liang, Fengming Li, Qiuping Zhang, Jingni Wang, Tuo Ma, Danrong Li, Huaxin Hou
Publikováno v:
Future Medicinal Chemistry. 15:129-145
Background: Endoplasmic reticulum (ER) stress is a therapeutic target in cancer given its regulation of bioenergetics and cell death. Methodology & results: We synthesized 14 ER stress-triggered anthraquinone derivatives by introducing an amino group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1628f5435bf9cbd9145e60371bc0233
https://doi.org/10.4155/fmc-2022-0217
https://doi.org/10.4155/fmc-2022-0217
Publikováno v:
Journal of Molecular Structure. 1279:134950
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d4c0f7697a36e65ddb0ae0c98e5ae82
https://doi.org/10.1016/j.molstruc.2023.134950
https://doi.org/10.1016/j.molstruc.2023.134950
Autor:
Yanping Zhong, Danrong Li, Huifeng Pang, Yunfeng Liu, Huaxin Hou, Wei Tian, Fu Lan, Jiankang Kang
Publikováno v:
Anti-Cancer Drugs. 30:1038-1047
Triple negative breast cancer (TNBC) has very poor prognosis and no efficacious therapeutic options due to the absence of a validated molecular target. Therefore, novel therapeutic strategies against TNBC are urgently needed. Our team synthesized and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b2aa8b679c0499df80cb1757b54475
https://doi.org/10.1097/cad.0000000000000820
https://doi.org/10.1097/cad.0000000000000820
Publikováno v:
IEICE Transactions on Information and Systems. :1833-1841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206baf2a207e1aaabeb6055b30b4fcfe
https://doi.org/10.1587/transinf.2019edp7043
https://doi.org/10.1587/transinf.2019edp7043
Autor:
Zhengying Su, Danrong Li, Dandan Liang, Zhaoquan Li, Huaxin Hou, Chunmiao Wang, Wei Tian, Junying Li, Fu Lan
Publikováno v:
ACS Med Chem Lett
[Image: see text] Novel anthraquinone compounds that induce ER stress and paraptosis-like cell death were designed and synthesized. Compound 4a is the first organic micromolecule to kill tumor cells by only paraptosis, and its mechanism of action has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e1ef5929e168124716f81f6d59db8a
https://doi.org/10.1021/acsmedchemlett.8b00624
https://doi.org/10.1021/acsmedchemlett.8b00624
Autor:
Huaxin Hou, Xinxiao Li, Junying Li, Lina Zhai, Wei Tian, Jiankang Kang, Danrong Li, Yanping Zhong
Publikováno v:
International journal of oncology. 58(5)
At present, effective therapeutic drugs for triple‑negative breast cancer (TNBC) are lacking due to the absence of identified or available targets. Therefore, the present study aimed to identify key molecular targets and a specific targeted therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4097e5e6e22b5be464d026c6eb891b
https://pubmed.ncbi.nlm.nih.gov/33760108
https://pubmed.ncbi.nlm.nih.gov/33760108
Publikováno v:
Future Medicinal Chemistry.
Anthraquinones exhibit a unique anticancer activity. Since their discovery, medicinal chemists have made several structural modifications, resulting in the design and synthesis of a large number of novel anthraquinone compounds with different biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d96e51d64f875415f2771dde5ae89d3
https://doi.org/10.4155/fmc-2019-0322
https://doi.org/10.4155/fmc-2019-0322
Publikováno v:
Science of The Total Environment. :73-79
This study prepared a novel low-cost surface functionalized carbon adsorbent (PPC) from biomass waste (pomelo peel) through a facile low-temperature (250 °C) one-step method under regular air atmosphere. The adsorption performance and mechanism of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee5fd4be85ba8b41e3a7065994132a1
https://doi.org/10.1016/j.scitotenv.2018.05.251
https://doi.org/10.1016/j.scitotenv.2018.05.251
Publikováno v:
Journal of The Electrochemical Society. 168:090517
Developing metal-free carbon as a new functional electrocatalyst to improve the performance of Li-O2 batteries has become the holy grail of many researchers. It is remarkable to design specific dopants/defects forms and structural adjustments to impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3c8907a32ca290e020c54b64ae51fe7
https://doi.org/10.1149/1945-7111/ac03f4
https://doi.org/10.1149/1945-7111/ac03f4