Výsledky vyhledávání

Photocontrollable Probes for Mitochondrial Protein Profiling

Autor: Shuhong Guo, Chaonan Yuan, Wenjie Lang, Danqi Hong, Jian Liu, Jintao Huang, Jia Dong, Jingyan Ge

Publikováno v: ChemBioChem. 23

The mitochondrion is the core site of cell signaling, energy metabolism and biosynthesis. Here, taking advantage of activity-based probes, we synthesized two photocontrollable probes (YGH-1 and YGH-2), composed of a mitochondrial localization moiety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b06ecc8a2b6c748a8fa2b372f72372
https://doi.org/10.1002/cbic.202200066

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EEG-based Major Depressive Disorder Detection Using Data Mining Techniques

Autor: Danqi, Hong, Xingxian, Huang, Yingshan, Shen, Haibo, Yu, Xiaomao, Fan, Gansen, Zhao, Wenbin, Lei, Haoyu, Luo

Publikováno v: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC).

Major depressive disorder (MDD) is a common mental illness characterized by a persistent feeling of low mood, sadness, fatigue, despair, etc.. In a serious case, patients with MDD may have suicidal thoughts or even suicidal behaviors. In clinical pra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6a53a7808b3a09dc9175d5c72b030c
https://doi.org/10.1109/embc46164.2021.9629907

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Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems

Autor: Jingyan Ge, Wenjie Lang, Jie Luo, Huang Jintao, Danqi Hong, Jian Liu, Dong Jia, Chaonan Yuan, Qing Zhu

Publikováno v: The Analyst. 144:3703-3709

Monoamine oxidase (MAO) is a membrane-bound mitochondrial enzyme that plays an important role by catalyzing oxidative deamination to maintain the homeostasis of neurotransmitters and other biogenic amines in living systems. MAO activity is critical f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a222bc4967bda22062a429bd24fb0d68
https://doi.org/10.1039/c9an00409b

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Design, synthesis and evaluation of protein disulfide isomerase inhibitors with nitric oxide releasing activity

Autor: Chuanhao Yao, Lin Li, Naidi Yang, Bo Peng, Wei Huang, Jingyan Ge, Jian Liu, Chengwu Zhang, Yaqi Ding, Zhenxiong Shi, Danqi Hong

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 30:126898

Protein disulfide isomerase (PDI), a chaperone protein mostly in endoplasmic reticulum, catalyzes disulfide bond breakage, formation, and rearrangement to promote protein folding. PDI is regarded as a new target for treatment of several disorders. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2275a6c3fab6729a1802b0803a23e8b
https://doi.org/10.1016/j.bmcl.2019.126898

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Differently Tagged Probes for Protein Profiling of Mitochondria

Autor: Huang Jintao, Qing Zhu, Danqi Hong, Linghui Qian, Lin Li, Jingyan Ge, Wenjie Lang, Dong Jia

Publikováno v: Chembiochem : a European journal of chemical biology. 20(9)

The mitochondrion is one of the most important organelles in the eukaryotic cell. Characterization of the mitochondrial proteome is a prerequisite for understanding its cellular functions at the molecular level. Here we report a proteomics method bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7909be48ab5be424fed3dcf622a29f
https://pubmed.ncbi.nlm.nih.gov/30600897

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A dual functional fluorogenic probe for visualization of intracellular pH and formaldehyde with distinct fluorescence signals

Autor: Jingyan Ge, Danqi Hong, Liquan Zhu, Qing Zhu, Zhenda Xie, Biao Yin, Jiajie Shen

Publikováno v: Organicbiomolecular chemistry. 16(25)

In this study, a single fluorescent probe (DPFP) containing a 1,8-naphthalimide dye and a homoallylamino group for imaging pH and formaldehyde (FA) has been developed that exhibits significant blue fluorescence (λem at 455 nm) under acidic pH condit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a2a2fbe7cebc21e26a18eb688604e4
https://pubmed.ncbi.nlm.nih.gov/29901667

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